Xinyuan Fan

PhD, Research Associate Professor

 

Email: xinyuanfan@pku.edu.cn; Tel: 010-62754127; Office: A622

 

EDUCATION

2010-2014

PhD in organic chemistry, Institute of Chemical Research of Catalonia, Tarragona, Spain

2003-2010

B.S & M.S. in biotechnology, Lanzhou University, Lanzhou, China

EXPERIENCE

2019-present, Research Associate Professor, College of Chemistry and Molecular Engineering, Peking University

2017-2019, Associate Professor of chemical biology, Nanjing Tech University

2015-2017, Postdoctoral Fellow, Peking-Tsinghua Center for Life Sciences, Peking University

 

RESEARCH INTERESTS
Bioorthogonal chemistry and chemical tools. 
Development of bioorthogonal chemistry and innovative chemical toolsfor the exploration of life sciences with spatiotemporal precision.

RECENT PUBLICATIONS
1, Ngai, W. S. C.; Yang, S.; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.; Fan, X.*; Chen, P. R.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis. J. Am. Chem. Soc. 2022, 144, DOI: 10.1021/jacs.1c12924.
2, Huang, Z.; Liu, Z.; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P. R.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. J. Am. Chem. Soc. 2021, 143 (44), 18714-18720.
3, Wang J; Wang X; Fan X*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems. ACS Cent. Sci. 2021, 7 (6), 929-943.
4, Zhu, J.; Dai, C.; Ma, M.; Yue, Y.; Fan, X.*, Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines. Org. Chem. Front. 2021, 8 (6): 1227-32.
5, Lizandara-Pueyo, C.*; Fan, X.*; Ayats, C.; Pericàs, M. A., Calcium carbonate as heterogeneous support for recyclable organocatalysts. J. Catal. 2021,393, 107-115.
6, Zhang, X.; Luo, H.; Fan, X.*; Chen, P.*, Development and applications of inverse-electron-demand Diels-Alder reaction in bioorthogonal chemistry. Sci. Sin. Chim. 2020,50 (10), 1280-1295.
7, Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis”, Org. Lett.2019,21 (1), 27-31.
8, Fan, X.*; Gong, X.; Ma, M.; Wang, R.; Walsh, P. J.* “Visible Light-Promoted CO2 Fixation with Imines to Synthesize Diaryl α-Amino Acids”, Nat. Commun.2018, 9(1), 4936.
9, Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Visible Light-Mediated Umpolung Reactivity of Imines: Ketimine Reductions with Cy2NMe and Water”, Org. Lett. 2018, 2433.
10, Fan, X.; Li, J.; Chen, P. R., Bioorthogonal chemistry in living animals. Natl. Sci. Rev.2017,4 (3), 300-302