Xinyuan Fan

PhD, Research Associate Professor

Email:;  Tel: 010-62754127;  Office: C610 


2019 – present, Research Associate Professor, Peking University 

2017 – 2019, Associate professor, Nanjing Tech University 

2014 – 2017, Postdoctoral fellow, Peking University 

2013 – University of Pennsylvania, Visiting scholar, Organic chemistry.

2010 – 2014, ICIQ - Institute of Chemical Research of Catalonia (Spain), Ph.D, Organic chemistry  

2003 – 2010, Lanzhou University, BS & MS, Biotechnology and Biochemistry


Chemical biology, Bioorthogonal photocatalysis 
Bioorthogonal chemistry, Photocatalytic chemistry


National Science Fund for Excellent Young Scholars of China 

NG Teng Fong/ Sino Scholarship for Outstanding Youth

Li Ge-Zhao Ning Youth Fund for Life Sciences



1. Zhu Y., Ding W., Fan X.*, Lin S.*, Chen P.*, “Genetically encoded bioorthogonal tryptophan decaging in living cells.” 

Nat. Chem. 2024, DOI: 10.1038/s41557-024-01463-7.

2. Liu, Z.; Guo, F.; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen, P.*; Fan, X.*, “Bioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples.” 

Nat. Commun. 2024, DOI: 10.1038/s41467-024-46985-3.

3. Liang, X.#; Qian, S.#; Lou, Z.; Hu, R.; Hou, Y.; Chen, P.*; Fan, X.*, “Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice.”   

Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202310920.

4. Zhang, X.; Huang, H.; Liu, Y.; Wu, Z.; Wang, F.; Fan, X.*; Chen, P. R.*; Wang, J.*, Optical Control of Protein Functions via Genetically Encoded Photocaged Aspartic Acids. 

J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c03701.

5. Liu, Y.; Ge, Y.; Zeng, R.; Ngai William Shu, C.; Fan, X.*; Chen, P.*, Proximity Chemistry in Living Systems. 

CCS Chem. 2023, 802-813.

6. Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.; Fan, X.*; Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging. 

Chem 2022, 2179-2191.

7. Ngai, W. S. C.; Yang, S.; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.; Fan, X.*; Chen, P.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis. 

J. Am. Chem. Soc. 2022, 144 (12), 5411-5417.

8. Luo, H.; Tang, W.; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.; Fan, X.*; Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells. 

Angew. Chem. Int. Ed. 2022, e202202008. 

9. Huang, Z.; Liu, Z.; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. 

J. Am. Chem. Soc. 2021, 143 (44), 18714-18720. 

10. Wang J; Wang X; Fan X*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems. 

ACS Cent. Sci. 2021 7 (6), 929-943. 


For full list of publications, please see: Xinyuan Fan - Google Scholar