Welcome to P. CHEN Lab!

Welcome to PENG CHEN Lab! We are a group of chemical biologists working on Protein CHemistry and ENgineering (P. CHEN).

We develop and integrate bio-compatible chemical transformations (3C: Crosslinking, Cleavage & conjuation) for spatial-temporal dissection of protein interactome in living systems and we explore therapeutic potential of these chemical biology innovations.

Selected References:

(1) Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C*, Chen P*. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019, 569, 509–513.

(2) Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen P*. Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions. J. Am. Chem. Soc. 2019, 141, 1833-37.

(3) Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen P*. An allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc. Natl. Acad. Sci. USA. 2017, 114, 13661-13666.

(4) Li J, Chen P*. Development and application of bond cleavage reactions in bioorthogonal chemistry. Nat. Chem. Biol. 2016, 12, 129-137.

(5) Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J, Chen P*. Palladium-triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-caged Tyrosine. J. Am. Chem. Soc. 2016, 138, 15118-15121

(6) Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen P*. Bioorthogonal chemical activation of kinases in living systems, ACS Cent. Sci. 2016, 2, 325-331.

(7) Li J, Jia S, Chen P*. Diels-Alder reaction-triggered bioorthogonal protein activation in living cells, Nat. Chem. Biol. 2014, 10, 1003-1005.

(8) Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P*. Palladium-triggered deprotection chemistry for protein activation in living cells, Nat. Chem. 2014, 6, 352-361.

(9) Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao B, Zeng S, Chen X, Chan J, He C*, Chen P*. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli, Nat. Chem. Biol. 2014, 10, 21-28.

(10) Li J, Lin S, Wang J, Jia S, Yang M, Zhang X, Hao Z, Chen P*. Ligand-free palladium-mediated site-specific protein labeling inside Gram-negative bacterial pathogens, J. Am. Chem. Soc. 2013, 135, 7330-7338.

(11) Zhang M, Lin S, Song X, Liu J, Fu Y, Fu X, Chang Z*, and Chen, P*. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance, Nat. Chem. Biol, 2011, 7, 671-7.