Li, C.; Li, X.; Wang, X.; Lei, X.
Science China Chemistry
Diversity-oriented synthesis (DOS) has been widely applied in the generation of a large collection of highly functionalized
molecules with diverse chemical skeletons. Herein, we report the diversity-oriented synthesis of a series of structurally diverse
bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis (RCM). This
approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.
diversity-oriented synthesis, tandem reaction, conjugate addition, aldol reaction, RCM
Diversity-oriented synthesis (DOS) has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons. Herein, we report the diversity-oriented synthesis of a series of structurally diverse bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis (RCM). This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies. diversity-oriented synthesis, tandem reaction, conjugate addition, aldol reaction, RCM