We just published our remarkable biosynthesis work on enzyme-catalyzed intermolecular [4+2] cycloaddition. The work was recently published on Nature Chem.
We reported Chrysomycin A derivitives, polycarcin V and gilvocarcin V, for the treatment of Tuberculosis. The work was recently published on ACS Central Science.
We have made big progress in the total synthesis of ent-kaurane diterpenoids
We reported the first arginine selective crosslinker and published on Nature Communications
We identified and developed novel selective DYRK 2 inhibitor
Dependence on the 26S proteasome is an Achilles’ heel for triplenegative
breast cancer (TNBC) andmultiplemyeloma (MM). The therapeutic
proteasome inhibitor, bortezomib, successfully targets MM
Our recent work on biomimetic synthesis of rhytidenone A and its mode of action was published on Angew Chemie International Edition
Rhytidenones family are spirobisnaphthalene natural products isolated from mangrove endophytic fungus Rhytidhysteron rufulum AS21B. In this study, we finished the biomimetic synthesis of complex rhyti…