We just revealed that CDK10 suppresses nucleic acid sensors-mediated antitumor immunity
We just reported the structure and mechanism of the human bile acid transporter OSTα/OSTβ
We just report an engineered aldehyde dehydrogenases for amide bond formation
We have decoded the complete 4-vinylanisole (4VA) biosynthetic pathway in locusts, identifying its precursors and key enzymes 4VPMT1/2. And we developed specific inhibitors enabling precise chemical control of 4VA production, effectively disrupting locust aggregation behavior.
Aggregation pheromone, 4-vinylanisole (4VA), is specifically released by gregarious migratory locust...
We just identified erucamide, a plant phytoalexin, blocks bacterial T3SS assembly by targeting HrcC, which disrupts bacterial pathogenesis and decreased infection susceptibility.
Plants employ immune receptors to perceive pathogen-associated molecular patterns (PAMPs) to trigger...
We just reported the cryo-EM structure of human TRPV1 in complex with SAF312, elucidating the structural foundation of its antagonistic effects on TRPV1.
Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thu...
We just reported the cryo-EM structures of hTRPV4 in a complex with two potent small-molecule antagonists A1 and A2, revealing the detailed binding pockets and regulatory mechanisms of TRPV4 gating.
The nonselective calcium-permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (...
We just reported the chemoenzymatic total synthesis approach of alchivemycin A that combines de novo skeleton construction and late-stage enzymatic oxidation reactions. The work was recently published on Nature Synthesis.
Alchivemycin A belongs to a unique class of polyketide natural products isolated from plant-deriv...
We just investigate the evolutionary origins of the intermolecular DAs in the biosynthesis of Moraceae plant-derived Diels-Alder-type secondary metabolites. The work was recently published on Nature communications.
Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity...
We just artificially reconstituted a biosynthetic pathway for the production of baccatin III in tobacco. The work was recently published on Science.
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a highly ...