Dependence on the 26S proteasome is an Achilles’ heel for triplenegative
breast cancer (TNBC) andmultiplemyeloma (MM). The therapeutic
proteasome inhibitor, bortezomib, successfully targets MM
Rhytidenones family are spirobisnaphthalene natural products isolated from mangrove endophytic fungus Rhytidhysteron rufulum AS21B. In this study, we finished the biomimetic synthesis of complex rhyti…