We have decoded the complete 4-vinylanisole (4VA) biosynthetic pathway in locusts, identifying its precursors and key enzymes 4VPMT1/2. And we developed specific inhibitors enabling precise chemical control of 4VA production, effectively disrupting locust aggregation behavior.
Aggregation pheromone, 4-vinylanisole (4VA), is specifically released by gregarious migratory locust...
We just identified erucamide, a plant phytoalexin, blocks bacterial T3SS assembly by targeting HrcC, which disrupts bacterial pathogenesis and decreased infection susceptibility.
Plants employ immune receptors to perceive pathogen-associated molecular patterns (PAMPs) to trigger...
We just reported the cryo-EM structure of human TRPV1 in complex with SAF312, elucidating the structural foundation of its antagonistic effects on TRPV1.
Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thu...
We just reported the cryo-EM structures of hTRPV4 in a complex with two potent small-molecule antagonists A1 and A2, revealing the detailed binding pockets and regulatory mechanisms of TRPV4 gating.
The nonselective calcium-permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (...
We just reported the chemoenzymatic total synthesis approach of alchivemycin A that combines de novo skeleton construction and late-stage enzymatic oxidation reactions. The work was recently published on Nature Synthesis.
Alchivemycin A belongs to a unique class of polyketide natural products isolated from plant-deriv...
We just investigate the evolutionary origins of the intermolecular DAs in the biosynthesis of Moraceae plant-derived Diels-Alder-type secondary metabolites. The work was recently published on Nature communications.
Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity...
We just artificially reconstituted a biosynthetic pathway for the production of baccatin III in tobacco. The work was recently published on Science.
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a highly ...
We just published the first structure of Fhb7 at 2.41 Å and revealed a unique catalytic mechanism of epoxide opening transformation in GST family proteins.
In the era of global climate change, the increasingly severe Fusarium head blight (FHB) and deoxyniv...
We just published the first total syntheses of several bis-b-carboline alkaloids, picrasidines G, S, R, and T, and natural product-like derivatives in a divergent manner. The work was recently published on Chemical Science.
Divergent total syntheses of ITHQ-type bis-bcarboline alkaloids by regio-selective formal aza-[4
...
We just published our remarkable work on identification of the potential antidiabetic target microbial DPP4 by microbial-host-isozyme analyses. The work was recently published on Science.
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target