We have recently developed the second generation TQ-ligation, and demonstrated it as a powerful method to facilitate chemical biology studies. Second Generation TQ-Ligation for Cell Organelle Imaging Xiaoyun Zhang, Ting Dong, Qiang Li, Xiaohui Liu, Lin Li, She Chen, and Xiaoguang Lei* ACS Chem. Biol. 2015, DOI: 10.1021/acschembio.5b00193 ABSTRACT: Bioorthogonal ligations play a crucial role […]
Our latest discovery on the novel mode of action for a complex natural product has been highlighted by a news story on C&E News. Congratulations to Ting and Chao! “Chemists Explore Ways To Manipulate The Immune System” http://cen.acs.org/articles/93/i15/Chemists-Explore-Ways-Manipulate-Immune.html
Ting and Chao’s latest research breakthough on the chemical biology studies of complex natural product has been published on Nature Communications. Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Chen, X.; Li, L.; Cao, R.; Huang, N.; He, S.*; Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature […]
Prof. Lei recently received “2015 The Distinguished Lectureship Award” by Chemical Society of Japan (CSJ). He was invited to attend the CSJ annual meeting in Chiba, March 26-29 and present a keynote lecture entitled “Dissectin Cell Death with Complex Natural Products”. This prestigious award recognizes Prof. Lei’s remarkable contributions to the chemical biology studies of […]
Congratulations to Benke, Houhua, Jinbao and Jing for their latest total synthesis published on ACIE! Angew. Chem. Int. Ed. 2014 , DOI: 10.1002/anie.201409503 Abstract: Utilizing a late-stage enamine bromofunctionlization strategy, we have accomplished a 12-step total synthesis of (-)-huperzine Q as well as the first total syntheses of (+)-lycopladines B and C. We also report […]
Natural products have played a crucial role in the development of new therapeutic agents. However, the target identification for natural products is still challenging due to the structural complexity and the lack of efficient biochemical methods. In the previous studies, we have accomplished the collective total syntheses of a number of structurally complex and bioactive […]
Our graduate students Mr. Jianguang Han, Mr. Weilong Liu, Mr. Benke Hong, Ms. Ting Dong, and Mr. Jing Zhang won the “2014 NIBS Excellent Student Award” for their outstanding performance in scientific research.?Big congrats?to all of them!!! Our previous awardees are: 2011 Mr. Chao Li; 2012 Mr. Xiaoming Wang; 2013 Mr. Daohong Liao and Mr. […]
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We have developed the second generation TQ-Ligation
We have recently developed the second generation TQ-ligation, and demonstrated it as a powerful method to facilitate chemical biology studies. Second Generation TQ-Ligation for Cell Organelle Imaging Xiaoyun Zhang, Ting Dong, Qiang Li, Xiaohui Liu, Lin Li, She Chen, and Xiaoguang Lei* ACS Chem. Biol. 2015, DOI: 10.1021/acschembio.5b00193 ABSTRACT: Bioorthogonal ligations play a crucial role […]
Our latest research work has been reported by C&E News
Our latest discovery on the novel mode of action for a complex natural product has been highlighted by a news story on C&E News. Congratulations to Ting and Chao! “Chemists Explore Ways To Manipulate The Immune System” http://cen.acs.org/articles/93/i15/Chemists-Explore-Ways-Manipulate-Immune.html
Uncovered the mode of action for ainsliadimer A
Ting and Chao’s latest research breakthough on the chemical biology studies of complex natural product has been published on Nature Communications. Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Chen, X.; Li, L.; Cao, R.; Huang, N.; He, S.*; Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature […]
Prof. Lei received 2015 The Distinguished Lectureship Award by CSJ
Prof. Lei recently received “2015 The Distinguished Lectureship Award” by Chemical Society of Japan (CSJ). He was invited to attend the CSJ annual meeting in Chiba, March 26-29 and present a keynote lecture entitled “Dissectin Cell Death with Complex Natural Products”. This prestigious award recognizes Prof. Lei’s remarkable contributions to the chemical biology studies of […]
Celebration party, 2015/1/31
We have a celebration party for Weilong and Jing’s significant breakthroughs in complex natural product syntheses!
Prof. Lei received Outstanding Young Talent Award by Beijing Government, 2014
Prof. Lei received the Roche Young Investigator Award, 2014
Total Syntheses of (-)-Huperzine Q, (+)-Lycopladines B and C
Congratulations to Benke, Houhua, Jinbao and Jing for their latest total synthesis published on ACIE! Angew. Chem. Int. Ed. 2014 , DOI: 10.1002/anie.201409503 Abstract: Utilizing a late-stage enamine bromofunctionlization strategy, we have accomplished a 12-step total synthesis of (-)-huperzine Q as well as the first total syntheses of (+)-lycopladines B and C. We also report […]
We have discovered a new mode of anticancer action of the natural product ainsliatrimer A
Natural products have played a crucial role in the development of new therapeutic agents. However, the target identification for natural products is still challenging due to the structural complexity and the lack of efficient biochemical methods. In the previous studies, we have accomplished the collective total syntheses of a number of structurally complex and bioactive […]
Jianguang, Weilong, Benke, Ting, and Jing won the 2014 NIBS Excellent Student Award!
Our graduate students Mr. Jianguang Han, Mr. Weilong Liu, Mr. Benke Hong, Ms. Ting Dong, and Mr. Jing Zhang won the “2014 NIBS Excellent Student Award” for their outstanding performance in scientific research.?Big congrats?to all of them!!! Our previous awardees are: 2011 Mr. Chao Li; 2012 Mr. Xiaoming Wang; 2013 Mr. Daohong Liao and Mr. […]