Recently Prof. Lei ?received the 2017?KAIST School of Molecular Science Lectureship Award and gave a plenary lecture on natural product total synthesis and chemical biology at KAIST, South Korea.
Prof. Lei has won the prestigious 2017 Tetrahedron Young Investigator Award in ?Bioorganic and Medicinal Chemistry Prof. Xiaoguang Lei will give a plenary lecture at the?18th Tetrahedron Symposium, Budapest, Hungary, where?he will be formally presented with?his award. He also receives a certificate and an award of US $3,000. Additionally, a Symposium-in-Print in one of the […]
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be labeled with stable isotopes for quantitation. By locating the flexible proteins […]
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis Highlights Kongensin A (KA) is a potent inhibitor of necroptosis and an inducer of apoptosis KA inhibits necroptosis by preventing the activation of RIPK3 TQ ligation enables the identification of HSP90 as a cellular target of KA KA covalently binds to HSP90 […]
Reported is the first scalable synthesis of?rac-jungermannenones?B and C starting from the commercially available and inexpensive geraniol in 10 and 9 steps, respectively. The unique jungermannenone framework is rapidly assembled by an unprecedented regioselective 1,6-dienyne reductive cyclization reaction which proceeds through a vinyl radical cyclization/allylic radical isomerization mechanism. DFT calculations explain the high regioselectivity observed […]
Abstract: The increase and spread of Gram-negative bacteria resistant to almost all currently available β-lactam antibiotics is a major global health problem. The cause for drug resistance is primarily due to the acquisition of metallo-β-lactamases such as NDM-1. Aspergillomarasmine A (AMA), a fungal natural product, is an inhibitor of NDM-1 and has shown promising in […]
Recently, Prof. Lei has received “Wei Shan Natural Product Synthesis” Award from Chinese Chemical Society. This award was set up in the memory of the late Prof. Wei-Shan Zhou for his remarkable achievements in natural product synthesis, and the goal of this award is to recognize the leading organic chemists in China who has made […]
Our latest Enantioselective Total Synthesis of (?)-Incarviatone A (JACS 2015, 137, 11946-11949) has been highlighted by C&E News. http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic […]
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Prof. Lei has received the 2017 KAIST School of Molecular Science Lectureship Award
Recently Prof. Lei ?received the 2017?KAIST School of Molecular Science Lectureship Award and gave a plenary lecture on natural product total synthesis and chemical biology at KAIST, South Korea.
Prof. Lei has received the prestigious 2017 Tetrahedron Young Investigator Award
Prof. Lei has won the prestigious 2017 Tetrahedron Young Investigator Award in ?Bioorganic and Medicinal Chemistry Prof. Xiaoguang Lei will give a plenary lecture at the?18th Tetrahedron Symposium, Budapest, Hungary, where?he will be formally presented with?his award. He also receives a certificate and an award of US $3,000. Additionally, a Symposium-in-Print in one of the […]
We have published a latest eLife paper to report the new CXMS method
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be labeled with stable isotopes for quantitation. By locating the flexible proteins […]
We have published a latest Cell Chemical Biology paper on necroptosis
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis Highlights Kongensin A (KA) is a potent inhibitor of necroptosis and an inducer of apoptosis KA inhibits necroptosis by preventing the activation of RIPK3 TQ ligation enables the identification of HSP90 as a cellular target of KA KA covalently binds to HSP90 […]
We report the first scalable total synthesis of tetracyclic diterpenoid jungermannenones B and C
Reported is the first scalable synthesis of?rac-jungermannenones?B and C starting from the commercially available and inexpensive geraniol in 10 and 9 steps, respectively. The unique jungermannenone framework is rapidly assembled by an unprecedented regioselective 1,6-dienyne reductive cyclization reaction which proceeds through a vinyl radical cyclization/allylic radical isomerization mechanism. DFT calculations explain the high regioselectivity observed […]
We report the first total synthesis and stereochemical configuration reassignment of aspergillomarasmine A
Abstract: The increase and spread of Gram-negative bacteria resistant to almost all currently available β-lactam antibiotics is a major global health problem. The cause for drug resistance is primarily due to the acquisition of metallo-β-lactamases such as NDM-1. Aspergillomarasmine A (AMA), a fungal natural product, is an inhibitor of NDM-1 and has shown promising in […]
Prof. Lei has received Roche Chinese Young Investigator Award of 2015
Prof. Lei recently received Roche Chinese Young Investigator Award of 2015. He was invited to give a lecture on the 3rd Roche-RSC symposium. ?
Prof. Lei has received “Wei Shan Natural Product Synthesis” Award
Recently, Prof. Lei has received “Wei Shan Natural Product Synthesis” Award from Chinese Chemical Society. This award was set up in the memory of the late Prof. Wei-Shan Zhou for his remarkable achievements in natural product synthesis, and the goal of this award is to recognize the leading organic chemists in China who has made […]
Our latest total synthesis has been highlighted by C&E News
Our latest Enantioselective Total Synthesis of (?)-Incarviatone A (JACS 2015, 137, 11946-11949) has been highlighted by C&E News. http://cen.acs.org/articles/93/i38/Multi-CH-Functionalizations.html
We have accomplished the first total synthesis of (-)-incarviatone A
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic […]