报告摘要

In this talk, three case studies will be presented to demonstrate how to develop various medical devices, particular point-of-care or portable devices with aggregation induced emission luminogens (AIEgens) together ^[1]. In details, (1) a point-of-care device has been developed to monitor human serum albumin (HSA) in urine with clinical trial results to establish a machine learning model for monitoring CKD and DKD in home settings. This device can be used as a platform for other biomarkers detection ^[2-3]. (2) A metasurface device has been developed to fit the AIEgen particular for HSA detection. This device can significantly increase the detection threshold and have the high throughput screening ability for biomarkers in body fluids ^[4] and (3) a portable vortex fluidic device (p-VFD) has been developed to fast the neurodegenerative marker called neurotrophin receptor p75 extracellular domain (p75ECD) detection, which can be used to assess the prognosis, disease severity and progression of amyotrophic lateral sclerosis (ALS) ^[5].

Reference

[1] X Zhang, B Yao, Q Hu, Y Hong, A Wallace, K Reynolds, C Ramsey, A Maeder, R Reed, Y Tang. Materials Chemistry Frontiers 4 (9), 2548-2570, 2020.

[2] ATT Pham, D Tohl, A Wallace, Q Hu, J Li, KJ Reynolds, Y Tang. Sensing and Bio-Sensing Research 37, 100504, 2022.

[3] J Li, Y Tang, ATT Pham, D Tohl, K Reynolds, CS Lee, R Juneja, S Ullah, J Gleadle. Nephrology 27, 90-91, 2022.

[4] Q Hu, M Iwanaga, Y Tang. Advanced Optical Materials, 2400868, 2024.

[5] X Luo, A Heydari, D Renfrey, Z Gardner, S He, Y Tang, GA. Weiss, M Rogers, CL. Raston. ChemSusChem, e202401008, 2024.

报告人简介

Youhong Tang is a Matthew Flinders Professor and was an Australian Research Council-Discovery Early Career Researcher at Flinders University. Currently, he is a Research Leader in Institute for NanoScale Science and Technology and Medical Device Research Institute at Flinders University. He is a Project Management Professional of Project Management Institute, US since 2008 and was elected as a Fellow of Royal Society of Chemistry, UK in 2018, a Fellow of Royal Australia Chemical Institute, Australia in 2021, a Certificated Materials Professional, Australia in 2021 and a Fellow of International Association of Advanced Materials, Sweden in 2024.

Youhong obtained his PhD degree from Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology in 2007 and moved to Flinders University in 2012 from Centre for Advanced Materials Technology, the University of Sydney. His research interests mainly focus on structure-processing-property relationship of polymeric (nano) materials/composites for sustainability and chemo/ biosensors and their devices with aggregation-induced emission features.