| |
主讲课程：
生物化学（化学院本科生课程）
研究领域和兴趣：
有机小分子化合物库的构建和化学基因组学研究
化学基因组学是一门新兴的交叉学科，是探索和理解重要生命过程的方法和手段。我们致力于发展简洁高效的、能有效实现化合物多样性的组合合成研究；通过天然产物及其类似物的组合合成，进一步通过生物筛选来寻找和发现探索生命过程的小分子探针以及具有特定生物活性的药物先导化合物。
代表性论文和专著：
-
Yefeng Tang, Yandong Zhang, Mingji Dai, Tuoping Luo, Lujiang Deng, Jiahua Chen*, and Zhen Yang*, A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the CO-Catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation, Org.Lett. 2005, 7, 885-888
-
Yandong Zhang, Yefeng Tang, Tuoping Luo, Juan Shen, Jiahua Chen*, and Zhen Yang*, Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A, Org. Lett. 2006, 8, 107-110
-
Zhibo Ma, Zheng Xiang, Tuoping Luo, Kui Lu, Zhibin Xu, Jiahua Chen*, Zhen Yang*, Synthesis of Functionalized Quinolines via Ugi and Pd-Catalyzed Intramolecular Arylation ReactionsJ. Comb. Chem. 2006; 8(5); 696-704.
-
Yongxiang Liu, Kui lu, Mingji Dai, Kai Wang, Wanqing Wu, Jiahua Chen* Junmin Quan* and Zhen Yang*, An Efficient One-pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions, Org. Lett, 2007, 9, 805-808
-
Yandong Zhang, Weiwu Ren, Yu Lan, Qing Xiao, Kai Wang, Jie Xu, Jiahua Chen*, and Zhen Yang*, Stereoselective Construction of an Unpricedented 7-8 Fused Ring System in Micrandilactone A by [3,3]-Sigmatropic Rearrangement, Org. Lett. 2008, 10, 665-668
-
Nengdong Wang, Jiang Xiang, Zhibo Ma, Junmin Quan, Jiahua Chen, and Zhen Yang, A Concise and Diversity-Oriented Apporach to the Synthesis of SAG Derivatives, J. Comb. Chem. 2008, 10, 825-834
|
北大化学微信