唐淳

教授,博士生导师

生物大分子动态学,生物物理化学,整合结构生物学

办公室:化学楼 B-205
电话:010-62758440
电子信箱:Tang_Chun@pku.edu.cn
课题组网站:http://www.tanglab.org
https://orcid.org/0000-0001-6477-6500
https://scholar.google.com/citations?user=M1JwkrwAAAAJ&hl=en

 

科研经历:

  • 2020 –,教授,博士生导师,北京大学化学与分子工程学院
  • 2020 – ,研究员, 北大清华生命科学联合中心
  • 2010 – , 研究员,中国科学院武汉物理与数学研究所,中国科学院生物磁共振分析重点实验室
  • 2008 – 2010,助理教授,美国密苏里大学,哥伦比亚分校
  • 2003 – 2008,博士后,美国国立健康研究院,合作导师 G. Marius Clore
  • 2003,理学博士,美国马里兰大学,巴尔的摩郡分校,导师 Michael F. Summers
  • 1998,理学学士,浙江大学生物系

奖项奖励:

  • “万人计划”科技创新领军人才(2019)
  • 科技部创新创业辅导师(2018)
  • 国务院政府特殊津贴 (2016)
  • “万人计划”青年拔尖人才(2014)
  • 国家杰出青年科学基金(2013)
  • 美国霍华德休斯国际青年科学家(2012)
  • 中国物理学会王天眷波谱学奖(2012)
  • 中国科学院“百人计划”(2011)

研究领域:

  • 发展核磁方法,重点关注顺磁核磁的原子分子探针开发,更好表征蛋白质、RNA等生物大分子的动态结构和瞬态相互作用。代表性论文:
    1. Gong Z, Charles DS, Tang C (2018) Theory and practice of using solvent paramagnetic relaxation enhancement to characterize protein conformational dynamics. Methods, 148:48-56
    2. Jiang WX, Gu XH, Dong X, Tang C. (2017). Lanthanoid tagging via an unnatural amino acid for protein structure characterization. J Biomol NMR, 67:273-282
    3. Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56:1002-1006
    4. Liu Z, Gong Z, Dong X, Tang C. (2016) Transient protein-protein interactions visualized by solution NMR. BBA Proteins and Proteomics, 1864:115-122
    5. Xing Q, Huang P, Yang J, Sun JQ, Gong Z, Dong X, Guo DC, Chen SM, Yang YH, Wang Y, Yang MH, Yi M, Ding YM, Liu ML, Zhang WP, Tang C. (2014) Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Angew Chem Int Ed, 53:11501-11505

  • 发展整合结构生物学的计算方法,联合运用小角散射、单分子荧光、质谱交联等技术,发展质谱交联数据的定量优化方法。代表性论文:
    1. Gong Z, Ye SX, Tang C. (2020) Tightening the crosslinking distance restraints for better resolution of protein structure and dynamics. Structure, DOI: 10.1016/j.str.2020.07.010
    2. Gong Z, Ye SX, Nie ZF, Tang C. (2020) The conformational preference of chemical crosslinkers determines the crosslinking probability of reactive protein residues. J Phy Chem B, 123:4446-4453
    3. Tang C, Gong Z. (2020) Integrating Non-NMR Distance restraints to augment NMR depiction of protein structure and dynamics. J Mol Biol, 432:2913-2929
    4. Liu Z, Gong Z, Cao Y, Ding YH, Dong MQ, Lu YB, Zhang WP, Tang C. (2018). Characterizing protein dynamics with integrative use of bulk and single-molecule techniques. Biochemistry, 57:305-313
    5. Ding YH, Gong Z, Dong X, Liu K, Liu Z, Liu C, He SM, Dong MQ, Tang C. (2017). Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem, 292:1187-1196

  • 研究化学修饰对生物大分子动态结构的调控作用,重点关注泛素的磷酸化及 RNA的m6A甲基化的影响。代表性论文:
    1. Tang C, Zhang WP. (2020) How phosphorylation by PINK1 remodels the ubiquitin system, a perspective from structure and dynamics. Biochemistry, 59:26-33
    2. You ZY, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang YS, Zhang HT, Peng C, Zhou TH, Tang C, Liu W. (2019) Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun, 10:5792
    3. Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10:272-284
    4. Dong X, Gong Z, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C. (2017). Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci, USA, 114:6770-6775
    5. Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML, Tang C. (2015) Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. eLife, 4:e05767
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