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唐淳

教授，博士生导师

生物磁共振，生物物理化学，生物分子动态学

办公室：化学楼 A-530
电话：010-62758440
电子信箱：tc@pku.edu.cn
课题组网站：http://tanglab.pku.edu.cn

研究兴趣

 

实验室聚焦生物大分子的结构动态，关注那些传统方法难以捕捉的“看不见的构象”，阐释生物大分子构像相关的生理病理功能。在后 AlphaFold 时代，我们致力于突破AI预测的局限，针对固有无序蛋白与复杂构象系综，发展并整合核磁、质谱、单分子荧光等多尺度实验技术。结合基于AI的计算预测与实验表征的闭环迭代，开发深度学习算法解析谱学数据，构建动态分子图像。通过与临床团队合作，探索神经退行性疾病相关蛋白的异常构象，发展疾病的早期诊断方法，揭示疾病发生的机制，推动从分子机制到临床应用的转化。

 

学术简历

 

  • 2020 - 至今 博雅特聘教授，北京大学，化学与分子工程学院
  • 2020 - 至今 研究员，北大-清华生命科学联合中心
  • 2021 - 至今 研究员，北京大学，定量生物学中心
  • 2017 - 2025 理事长，中国生物物理学会，生物磁共振分会
  • 2010 - 2020 研究员，中国科学院，武汉物理与数学研究所
  • 2015 - 2020 主任，中国科学院，生物磁共振分析重点实验室
  • 2008 - 2010 助理教授，美国密苏里大学，生物化学系
  • 2003 - 2007 博士后，美国国立卫生研究院，糖尿病消化病和肾病研究所
  • 2000 - 2003 博士研究生，美国马里兰大学巴尔的摩郡分校，化学与生物化学系
  • 1998 - 1999 博士研究生，美国马里兰大学基础医学院，生物化学系
  • 1994 - 1998 本科生，浙江大学，生命科学与技术系

 

主要获奖及荣誉

 

  • 国家杰出青年科学基金
  • 美国霍华德休斯（HHMI）国际青年科学家
  • 科技部“万人计划”科技创新领军人才
  • 人社部“百千万人才工程”有突出贡献中青年科学家
  • 中国物理学会王天眷波谱学奖
  • 中组部“万人计划”青年拔尖人才
  • 国务院特殊津贴

 

代表性论文

  1. Gao T†, Wang X†, Xie Y†, Wang T, Lu Y, Huang L, Chen C, Zhang M, Ma X, Chen Y, Liang F, Lou Z, Li J, Yu Y, Wu J, Ma X, Wang H*, Tang C*, Zhang W*, PINK1 Deficiency Permits the Development of Lewy Body Dementia with Coexisting Aβ Pathology, Alzheimers Dement., 2025, in press († equal contribution)
  2. Meng L, Ye S, Pei K, Tang C*, Structural Dynamics of SARS-CoV-2 NSP4 C-Terminal Domain and Implications for Viral Processing, J. Mol. Biol. 2025, 169372
  3. Chen C, Gao T, Yi H, Zhang Y, Wang T, Lou Z, Wei T, Lu Y, Li T, Tang C*, Zhang W*, Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration, eLife 2025, 14:RP103945
  4. Chen Y, Huang Z, Cai E, Zhong S, Li H, Ju W, Yang J, Chen W*, Tang C*, Wang P*, Novel Vibrational Proteins, Anal. Chem. 2024, 96 (42), 16481-16486
  5. Hou X, Song B, Zhao C, Chu W, Ruan M, Dong X, Meng L, Gong Z, Weng Y, Zheng J*, Wang J*, Tang C*, Connecting Protein Millisecond Conformational Dynamics to Protein Thermal Stability, JACS Au 2024, 4 (8), 3310-3320
  6. Jiang Y, Zhang X, Nie H, Fan J, Di S, Fu H, Zhang X, Wang L, Tang C*, Dissecting Diazirine Photo-Reaction Mechanism for Protein Residue-Specific Cross-Linking and Distance Mapping. Nat. Commun. 2024, 15, 6060
  7. Zhu Y, Lin S, Meng L, Sun M, Liu M, Li J*, Tang C*, Gong Z*, ATP Promotes Protein Coacervation Through Conformational Compaction, J. Mol. Cell. Biol. 2024, 16 (8), mjae038
  8. Yan X, Liu F, Yan J, Hou M, Sun M, Zhang D, Gong Z, Dong X, Tang C*, Yin P*, WTAP–VIRMA Counteracts dsDNA Binding of the m6A Writer METTL3–METTL14 Complex and Maintains N6-Adenosine Methylation Activity. Cell Discov. 2023, 9, 100
  9. Di W, Xue K, Cai J, Zhu Z, Li Z, Fu H, Lei H, Hu W, Tang C*, Wang W*, Cao Y*, Single-Molecule Force Spectroscopy Reveals Cation-Π Interactions in Aqueous Media are Highly Affected by Cation Dehydration, Phys. Rev. Lett. 2023, 130, 118101
  10. Fu W, Yang H, Hu C, Liao J, Gong Z, Zhang M, Yang S, Ye S, Lei X, Sheng R, Zhang Z, Yao X, Tang C*, Li D*, Hou T*. Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer. ACS Cent. Sci. 2023, 9 (4), 675-684
  11. Yan X, Pei K, Guan Z, Liu F, Yan J, Jin X, Wang Q, Hou M, Tang C*, Yin P*. AI-Empowered Integrative Structural Characterization of m6A Methyltransferase Complex. Cell Res. 2023, 32 (12), 1124-1127
  12. Wang J, Tang Y, Gong Z, Jain R, Xiao F, Zhou Y, Tan D, Li Q, Huang N, Liu S, Ye K, Tang C*, Dong M*, Lei X*. Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers. Nat. Commun. 2022, 13 (1), 1-16
  13. Ma Y, Li H, Gong Z, Yang S, Wang P*, Tang C*. Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate. J. Am. Chem. Soc. 2022, 144 (11), 4716-4720
  14. Dong X, Qin LY, Gong Z, Qin S, Zhou HX*, Tang C*. Preferential interactions of a crowder protein with the specific binding site of a native protein complex, J. Phys. Chem. Lett., 2022, 13(3), 792–800
  15. Czaplewski C, Gong Z, Lubecka EA, Xue K, Tang C*, Liwo A*. Recent Developments in Data-Assisted Modeling of Flexible Proteins, Front. Mol. Biosci. 2021, 8, 765562
  16. Kogut M, Gong Z, Tang C*, Liwo A*. Pseudopotentials for coarse‐grained cross‐link‐assisted modeling of protein structures J. Comput. Chem. 2021, 42: 2054-2067
  17. Qin LY, Gong Z, Liu K, Dong X*, Tang C*. Kinetic Constraints in the Specific Interaction Between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors, Biomolecules 2021, 11, 1008
  18. Gong Z, Ye SX, Tang C*. Tightening the Crosslinking Distance Restraints for Better Resolution of Protein Structure and Dynamics. Structure 2020, 28, 1160-1167
  19. Yang J, Gong Z, Lu Y, Xu C, Wei T, Yang M, Zhan T, Yang Y, Lin L, Liu J, Tang C*, Zhang W*. FLIM-FRET based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane. J. Mol. Biol. 2020, 432, 4596-4611
  20. Gong Z, Yang S, Dong X, Yang QF, Zhu Y, Xiao Y, Tang C*. Hierarchical Conformational Dynamics Confers Thermal Adaptability to preQ1 RNA Riboswitches. J. Mol. Biol. 2020, 432, 4523-4543
  21. Gong Z, Ye S, Nie Z, Tang C*. The conformational preference of chemical crosslinkers determines the crosslinking probability of reactive protein residues. J. Phy. Chem. B, 2020, 123, 4446-4453
  22. Tang C*, Gong Z, Integrating Non-NMR Distance Restraints to Augment NMR Depiction of Protein Structure and Dynamics. J. Mol. Biol. 2020, 432:2913-2929
  23. Tang C*, Zhang WP*. How Phosphorylation by PINK1 Remodels the Ubiquitin System, A Perspective from Structure and Dynamics. Biochemistry 2020, 59, 26-33
  24. You Z, Jiang W, Qin L, Gong Z, Wan W, Li J, Wang Y, Zhang H, Peng C, Zhou T, Tang C*, Liu W*. Requirement for p62 Acetylation in the Aggregation of Ubiquitylated Proteins Under Nutrient Stress. Nat. Commun. 2019, 10, 5792
  25. Ye S, Gong Z, Yang J, An Y, Liu Z, Zhao Q, Lescop E, Dong X, Tang C*. Ubiquitin is Double-Phosphorylated by PINK1 for Enhanced pH-Sensitivity of Conformational Switch. Protein Cell 2019, 10, 908-913
  26. Liu Z, Dong X, Yi H, Yang J, Gong Z, Wang Y, Liu K, Zhang W*, Tang C*. Structural Basis for the Recognition of K48-Linked Ub Chain by Proteasomal Receptor Rpn13. Cell Discov. 2019, 5, 19
  27. Gong Z, Charles DS, Tang C*. Theory and Practice of Using Solvent Paramagnetic Relaxation Enhancement to Characterize Protein Conformational Dynamics. Methods 2018, 48, 48-56
  28. Huang J, Dong X, Gong Z, Qin L, Yang S, Zhu Y, Wang X, Zhang D, Zou T, Yin P*, Tang C*. Solution Structure of The RNA Recognition Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase. Protein Cell 2018, 10, 272-284
  29. Liu Z, Gong Z, Cao Y, Ding Y, Dong M, Lu Y, Zhang W*, Tang C*. Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. Biochemistry 2018, 57, 305-313
  30. Dong X, Gong Z, Lu Y, Liu K, Qing L, Ran M, Zhang CL, Liu Z, Zhang W*, Tang C*. Ubiquitin S65 Phosphorylation Engenders a pH-Sensitive Conformational Switch. Proc. Natl. Acad. Sci. 2017, 114, 6770-6775
  31. Jiang W, Gu X, Dong X, Tang C*. Lanthanoid Tagging via an Unnatural Amino Acid for Protein Structure Characterization. J. Biomol. NMR 2017, 67, 273-282
  32. Ding Y, Gong Z, Dong X, Liu K, Liu Z, Liu C, He S, Dong M*, Tang C*. Modeling Protein Excited-State Structures from "Over-Length" Chemical Cross-Links. J. Biol. Chem. 2017, 292, 1187-1196
  33. Gong Z, Gu X, Guo D, Wang J, Tang C*. Protein Structural Ensembles Visualized by Solvent Paramagnetic Relaxation Enhancement. Angew. Chem. Int. Ed. 2017, 56, 1002-1006
  34. Liu, Z, Gong Z, Jiang W, Yang J, Zhu W, Guo D, Zhang W, Liu M, Tang C*. Lys63-Linked Ubiquitin Chain Adopts Multiple Conformational States for Specific Target Recognition. eLife 2015, 4, e05767
  35. Liu Z, Gong Z, Dong X, Tang C*. Transient Protein-Protein Interactions Visualized by Solution NMR. BBA Proteins Proteomics 2015, 1864, 115-122.
  36. Xing Q, Huang P, Yang J, Sun J, Gong Z, Dong X, Guo D, Chen S, Yang Y, Wang Y, Yang, M. Yi M, Ding Y, Liu M, Zhang W, Tang C*. Visualizing an Ultra-Weak Protein-Protein Interaction in Phosphorylation Signaling. Angew Chem Int Ed 2014, 53, 11501-11505
  37. Liu Z, Gong Z, Guo D, Zhang W, Tang C*. Subtle Dynamics of holo Glutamine Binding Protein Revealed with a Rigid Paramagnetic Probe. Biochemistry 2014, 53, 1403-1409.
  38. Gu X, Gong, Z, Guo D, Zhang W, Tang C*. A Decadentate Gd(III)-Coordinating Paramagnetic Cosolvent for Protein Relaxation Enhancement Measurement. J. Biomol. NMR 2014, 58, 149-154.
  39. Liu Z, Zhang W, Xing Q, Ren X, Liu M, Tang C*. Noncovalent Dimerization of Ubiquitin. Angew. Chem. Intl. Ed. 2012, 51, 469-472
  40. Yu D, Volkov AN, Tang C*. (2009) Characterizing Dynamic Protein-Protein Interactions Using. Differentially Scaled Paramagnetic Relaxation Enhancement. J. Am. Chem. Soc. 2009, 131, 17291-17297
  41. Tang C, Louis JM, Anita A, Suh JY, Clore GM. Visualizing Transient Events in N-Terminal Auto-Processing of HIV-1 Protease. Nature 2008, 455, 693-696
  42. Tang C, Schwieters C, Clore GM. (2007) Open-to-Closed Transition in apo Maltose-Binding Protein Observed by Paramagnetic NMR. Nature 2007, 449, 1078-1082
  43. Tang C, Iwahara J, Clore GM. Visualization of Transient Encounter Complexes In Protein-Protein Association, Nature 2006, 444, 383-386

 

 

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