吕 华(Lu, Hua) 博 士


    研究员,北京大学化学与分子工程学院
    研究员,北京大学软物质科学与工程中心
    研究领域:高分子化学与材料、蛋白质化学、生物医药工程
    地址:北京大学化学与分子工程学院B105,邮编100871
    电话:45285; Email@pku.edu.cn: chemhualu
    课题组网站:http://www.chem.pku.edu.cn/luhua

主要研究方向

发展开环聚合方法,可控制备聚氨基酸和聚(硫)酯等功能高分子生物材料
2. 发展蛋白质化学,高效合成蛋白质-高分子偶联物
3. 发展基于蛋白质偶联物的生物医药医用

教育经历

2006/08 – 2011/05      博士, 美国伊利诺伊大学香槟分校材料系
2002/09 – 2006/07      学士,北京大学化学与分子工程学院

工作经历

2020/04 – 至 今    副主编,美国化学会期刊Biomacromolecules
2020/02 – 至 今    研究员(长聘),北京大学化学与分子工程学院
2014/02 – 2020/01    研究员,北京大学化学与分子工程学院
2011/07 – 2014/05      博士后,Scripps研究所化学系

部分获奖及荣誉

ACS PMSE Young Investigator Symposium (2020)
日本高分子学会(SPSJ)An Invited lecturer of International Leading Young Scientist(2020)
中国化学会高分子青年学者奖(2019)
中国化学会青年化学奖(2017)
国家自然科学基金委员会"优秀青年科学基金"(2017)
ACS-AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry(2013)
IUPAC Prize for Young Chemists, Honorable Mention(2012)
Damon Runyon癌症研究基金会博士后奖学金 (2011-2014)
伊利诺伊大学材料系Racheff-Intel Award (Top Winner, 2011)
第34届国际化学奥林匹克竞赛金牌(2002)

代表性论文

  1. Wei Xiong, Wenying Chang, Dong Shi, Lijiang Yang, Ziyou Tian, Hao Wang, Zhengchu Zhang, Xuhao Zhou, Er-Qiang Chen,* and Hua Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, doi: 10.1016/j.chempr.2020.06.003.
  2. Jingsong Yuan, Dong Shi, Yi Zhang, Jianhua Lu, Letian Wang, Er-Qiang Chen,* and Hua Lu*, “4-Hydroxy-L-Proline as a General Platform for Stereoregular Aliphatic Polyesters: Controlled Ring-Opening Polymerization, Facile Functionalization, and Site-Specific Bioconjugation”, CCS Chem. 2020, 2, 236-244.
  3. Jianhua Lu, Hao Wang, Ziyou Tian, Yingqin Hou, and Hua Lu*, “Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein-Polydisulfide Conjugates”, J. Am. Chem. Soc. 2020, 142, 1217-1221.
  4. Guangqi Wu, Chenglong Ge, Xingyi Liu, Shuo Wang, Letian Wang, Lichen Yin,* and Hua Lu*, “Synthesis of water soluble and multi-responsive selenopolypeptides via ring-opening polymerization of N-carboxyanhydrides”, Chem. Commun. 2019, 55, 7860-7863.
  5. Yingqin Hou and Hua Lu*, “Protein PEPylation: A New Paradigm of Protein−Polymer Conjugation”, Bioconjugate Chem. 2019, 30, 1604-1616 (Invited Review).
  6. Jingsong Yuan, Wei Xiong, Xuhao Zhou, Yi Zhang, Dong Shi, Zi-Chen Li, and Hua Lu*, “4-Hydroxyproline-Derived Sustainable Polythioesters: Controlled Ring-Opening Polymerization, Complete Recyclability, and Facile Functionalization”, J. Am. Chem. Soc. 2019, 141, 4928-4935 (ACS Editors’ Choice, Featured as the Front Cover, also highlighted in Spotlights on Recent JACS Publications).
  7. Yingqin Hou, Yu Zhou, Hao Wang, Jialing Sun, Ruijue Wang, Kai Sheng, Jingsong Yuan, Yali Hu, Yu Chao, Zhuang Liu, and Hua Lu*, “Therapeutic Protein PEPylation: the Helix of Nonfouling Synthetic Polypeptides Minimizes the Anti-Drug Antibody Generation”, ACS. Cent. Sci. 2019, 5, 229-236
  8. Chong Zhang, Jingsong Yuan, Jianhua Lu, Yingqin Hou, Wei Xiong, and Hua Lu*, “From Neutral to Zwitterionic Poly(α-Amino Acid) Nonfouling Surfaces: Effects of Helical Conformation and Anchoring Orientation”, Biomaterials, 2018, 178, 728-737.
  9. Yingqin Hou,† Yu Zhou,† Hao Wang, Ruijue Wang, Jingsong Yuan, Yali Hu, Kai Sheng, Juan Feng, Shengtao Yang, and Hua Lu*, “Macrocyclization of Interferon-Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy”, J. Am. Chem. Soc. 2018, 140, 1170-1178. (†equal contribution) (highlighted byC&EN)
  10. Yingqin Hou,† Jingsong Yuan,† Yu Zhou, Jin Yu, and Hua Lu*, “A Concise Approach to Site-Specific Topological Protein-Poly(amino acid) Conjugates Enabled by in Situ -Generated Functionalities”, J. Am. Chem. Soc. 2016, 138, 10995-11000. (†equal contribution)
  11. Jingsong Yuan, Yunlong Sun, Jingyu Wang, and Hua Lu*, “Phenyl Trimethylsilyl Sulfide-Mediated Controlled Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides”, Biomacromolecules. 2016, 17, 891-896.
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