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刘志博

特聘研究员,博士生导师

放射化学生物学·核化学

北京大学 化学与分子工程学院
北京大学 北大-清华生命科学联合中心
电话:010-62759191
电子信箱:zbliu@pku.edu.cn
课题组网站:http://www.chem.pku.edu.cn/zliu/

研究兴趣:

  1. PET分子影像引导的活体蛋白激活及药物释放;
  2. 外源放疗及内源核素衰变激活的活体蛋白激活及药物释放;
  3. 含硼PET分子影像探针及硼中子捕获治疗药物的研究与临床应用;
  4. 新型医用核素的加速器生产研究与临床应用。

竞争性经费支持:

  1. 国家自然科学基金,面上项目,主持
  2. 国家自然科学基金委-中核集团联合基金,重点项目,主持
  3. 科技部重点研发计划,参与
  4. 北京大学苏南研究院创新项目,主持
  5. 李革赵宁生命科学青年研究基金,主持
  6. 北京大学 “临床医学+X” 青年项目,参与
  7. 北京协和医院预研项目,主持

获奖经历:

  • 2019.12, 药明康德生命化学青年学者奖
  • 2019.12, 北京大学青年教师教学基本功大赛一等奖
  • 2018.11, Fairchild Award, 18th International Congress of Neutron Capture Therapy
  • 2018.11, 北京大学绿叶生物青年科学家奖
  • 2015.06, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
  • 2015.04, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
  • 2014.08, Edward Piers Memorial Award, Edward Piers Foundation
  • 2014.06, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
  • 2013.06, Young Investigator Award, 37th CASNMMI
  • 2013.02, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation

代表性论文:

  1. Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426
  2. Liping Li, Ping Du, Yaxin Shi, Jiyuan Li, Zizhu Zhang, Tong Liu, Ruiping Zhang*, Zhibo Liu*, On-demand Biodegradable Boron Nitride Nanoparticles for Positron Emission Tomography Guided Boron Neutron Capture Therapy. ACS Nano, 2019, 13 (12), 13843-13852
  3. Jiyuan Li, Yaxin Shi, Zizhu Zhang, Hui Liu, Lixin Lang, Tong Liu, Xiaoyuan Chen*, Zhibo Liu*, A Metabolically Stable Boron-Derived Tyrosine Serves as a Theranostic Agent for Positron Emission Tomography Guided Boron Neutron Capture Therapy. Bioconjugate Chem, 2019, 30 (11), 2870-2878
  4. Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han, Yaxin Shi, Zhibo Liu* Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo. ACS Appl. Mater. Interfaces., 2018, 10 (49), 42165-42174
  5. Yaxin Shi, Jiyuan Li, Zizhu Zhang, Dongban Duan, Zhengchu Zhang, Hui Liu, Tong Liu, Zhibo Liu* Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy. ACS Appl. Mater. Interfaces., 2018, 10 (50), 43387-43395
  6. Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo, Zhibo Liu* Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy. Mol Pharm. 2018, 15(10): 4426-4433.
  7. Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang, Zhibo Liu*. Activating TiO2 Nanoparticle: Gallium-68 Serves As A High-Yielded Photon Emitter for Cerenkov Induced Photodynamic Therapy. ACS Appl. Mater. Interfaces. 2018, 10 (6), 5278–5286
  8. Zhibo Liu*, Xiaoyuan Chen* Simple Bioconjugate Chemistry Serves Great Clinical Advances: Albumin as A Versatile Platform for Diagnosis and Precision Therapy. Chem. Soc. Rev., 2016, 45, 1432-1456
  9. Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* Boramino Acid as A Marker for Amino Acid Transporter. Sci. Adv., 2015;1:e1500694 (co-corresponding author, highlighted on C&EN News)
  10. Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc, 2015, 10, 1423–1432 (co-corresponding author)
  11. Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin, An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed., 2014, 53, 11876–11880 (Cover feature, highlighted on C&EN News)
  12. Zhibo Liu, Ying Li, Jerome Lozada, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, David M. Perrin, Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at Exceptionally High Specific Activity For Click Conjugation, Angew. Chem. Int. Ed., 2013, 52, 2303-2307
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