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褚泰伟(课题组临时召集人)

博士,副教授

应用化学,核药物化学 

电话:62754319 传真:62754319
电子信箱:twchu@pku.edu.cn

1994年获兰州大学理学学士;
1997年获兰州大学理学硕士;
1997-1998年,中国辐射防护研究院工作;
2001年获北京大学理学博士学位。

主讲课程:

应用化学基础;综合化学实验;核燃料化学实验

研究领域和兴趣:

  1. 药物合成以及核素、荧光标记,用于心肌、肿瘤以及乏氧组织的显像;
  2. 开展核燃料循环化学的基础性和前瞻性研究,尤其是发展先进的核燃料后处理方法。

现有科研任务:

  1. 2011.1--2013.12 主持国家自然科学基金项目(21071010):Tc-99m标记的含有双生物还原基团的乏氧显像剂研究,35万元;
  2. 2011.1 --2013.12主持国家自然科学基金重大研究计划“先进核裂变能的燃料增殖与嬗变”培育项目(91026011):离子液体在核燃料干法后处理中的应用,80万;
  3. 2008.1 -- 2010 .12 主持国家自然科学基金项目(20771011):锝-99m标记的BnAO类乏氧显像剂的合成及机理研究,27万;
  4. 2006.9—2010.12 参与973项目(2006CB705700):分子影像关键科学技术问题的研究,53万;
  5. 2004.1--2006.12 主持国家自然科学基金项目:新型乏氧组织显像剂,21万;
  6. 2005.1--2007.12 北京市自然科学基金项目:新型肿瘤乏氧显像剂在核医学中的应用,15万;

代表性论文和专著:

  1. Xin Sun, Taiwei Chu*, Xiangyun Wang(2010). Preliminary studies of 99mTc-BnAO and its analogues: synthesis, radiolabeling and in vitro cell uptake. Nucl. Med. Biol. 37(2): 117-123.
  2. Xin Sun, Taiwei Chu*, Xiangyun Wang (2010). Tumor angiogenesis imaging agent: biodistribution of 131I-YG5 and 131I-Boc-YG5. Nuclear Science and Techniques 21(5): 257-261.
  3. Taiwei Chu*, Zejun Li, Xiangyun Wang (2009). Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker, Bioorgan. Med. Chem. Lett. 19(3): 658-661.
  4. Taiwei Chu, Hong Xu, Zhi Yang, Xiangyun Wang (2009). Synthesis and in vitro evaluation of three 99mTc-labeled hydroxamamide-based ligands as markers for hypoxic cells, Appl. Radiat. Isot. 67(4): 590-593.
  5. Liyan Sun, Taiwei Chu*, Yi Wang, Xiangyun Wang(2007). Radiolabeling and biodistribution of a nasopharyngeal carcinoma-targeting peptide identified by in vivo phage display,Acta Biochimica et Biophysica Sinica,39(8):624-632。
  6. Yu Zhang, Taiwei Chu*, Xuguang Gao, Xinqi Liu, Zhi Yang, Zhenquan Guo, Xiangyun Wang ( 2006 ) . Synthesis and preliminary biological evaluation of the 99m Tc labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers. Bioorgan. Med. Chem. Lett. , 16: 1831-1833.
  7. Xin Sun, Taiwei Chu*, Xinqi Liu, Xiangyun Wang (2006). t-Butyloxycarbonyl: an ordinary but promising group for protecting peptides from deiodination. Appl. Radiat. Isot., 64(6): 645-650.
  8. SUN Li-Yan, CHU Tai-Wei*, WANG Xiang-Yun(2006). Radiolabeling of filamentous phage peptide library with 99mTc and its biodistribution in normal mice. Progress in Biochemistry and Biophysics,33(12):1200-1206.
  9. Zejun Li, Taiwei Chu*, Xinqi Liu, Xiangyun Wang (2005). Synthesis and in vitro and in vivo evaluation of the radioiodinated nitroimidazole analogues as tumor hypoxia-imaging agents. Nucl. Med. Biol. 32(3): 225-231 .
  10. Hong Xu, Taiwei Chu*, Xiangyun Wang, Xinqi Liu (2005). Facile synthesis of bis(hydroxamamide)-based tetradentate ligands for 99mTc-radiopharmaceuticals. Appl. Radiat. Isot., 62(6): 919-922.
  11. Zejun Li, Yu Wei, Taiwei Chu*, Xiangyun Wang, Xinqi Liu, Yi Wang, Shaowen Hu (2005). Radioiodination, biodistribution and pharmacokinetics of berberine in mice. J. Radioanal. Nucl. Chem. 265(3): 355-359.
  12. Taiwei Chu, Shaowen Hu, Bing Wei, Yi Wang, Xinqi Liu, Xiangyun Wang (2004), Synthesis and Biological Results of a Technetium -99m -labeled 4-Nitroimidazole for Imaging Tumor Hypoxia. Bioorgan. Med. Chem. Lett., 14(3): 747-749.
  13. Taiwei Chu, Rujun Li, Shaowen Hu, Xinqi Liu, Xiangyun Wang (2004), Preparation and Biodistribution of Technetium -99m -labeled 1-(2-Nitroimidazole-1-yl) -propanhydroxyiminoamide (N2IPA) as a Tumor Hypoxia Marker, Nucl. Med. Biol . 31(2): 199-203.
  14. Taiwei Chu, Rujun Li, Shaowen Hu, Yi Wang, Xinqi Liu, Xiangyun Wang. Synthesis and biodistribution of the 99mTc nitrido complex with 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET). J. Radioanal. Nucl. Chem. ,2004, 261(1): 199-202.
  15. Taiwei Chu, Yu Zhang, Xinqi Liu, Yi Wang, Shaowen Hu, Xiangyun Wang (2004). Synthesis and biodistribution of 99mTc-carbonyltechnetium-labeled fatty acids. Appl. Radiat. Isot. 60(6): 845-850.

参加学术团体:

核化学与放射化学会副秘书长、委员;同位素学会委员;分子影像学专业委员会委员;《同位素》杂志编委。

欢迎校内外具有化学背景的本科生、研究生和博士后加入本研究小组攻读学位或从事研究。
更多信息参见核药物化学课题组主页:
www.chem.pku.edu.cn/appliedchem/heyaowu/index.htm

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