Gao, L.; Song, Q.; Liang, H.; Zhu, Y.; Wei, T.; Dong, N.; Xiao, J.; Shao, F.; Chen, X. “ Legionella Effector SetA as A General O-glucosyltransferase for Eukaryotic Proteins.” Nat. Chem. Biol. in press(2019).


Huang, R.; Han, M.; Meng, L.; Chen, X. “ Capture and Identification of RNA-Binding Proteins By Using Click Chemistry-Assisted RNA-Interactome Capture (CARIC) Strategy” J. Vis. Exp. 140, e58580(2018).

Liang, L.; Tang, H; Deng, Z.; Liu, Y,; Chen, X.; Wang, H. “ Ag Nanoparticles Inhibit the Growth of the Bryophyte, Physcomitrella Patens.” Ecotoxicol. Environ. Saf. 164, 739-748(2018).

Qin, K.; Zhu, Y; Qin, W.; Gao, J.; Shao, X.; Wang, Y.; Zhou, W.; Wang, C.; Chen, X. “ Quantitiative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker” ACS Chem. Biol. 13, 1983-1989 (2018).

Huang, R.; Han, M.; Meng, L; Chen, X. “ Transcriptome-wide discovery of coding and noncoding RNA-binding proteins” Proc. Natl. Acad. Sci. USA 115, E3879-E3887 (2018).

Wang, W.; Chen, X. “ Antibiotics-Based Fluorescent Probes for Selective Labeling of Gram-Negative and Gram-Positive Bacteria in Living Microbiota” Sci. China Chem. 61, 792-796 (2018).

Xu, Y.; Peng, L.; Wang, S.; Wang, A.; Ma, R.; Zhou, Y.; Yang, J.; Sun, D.; Lin, W.; Chen, X.; Zou, P. “ Hybrid Indicators for Fast and Sensitive Voltage Imaging” Angew. Chem. Int. Ed. 57, 3949-3953 (2018).

Sun, Y.; Hong, S.; Xie, R.; Huang, R.; Lei, R.; Cheng, B.; Sun, D.; Du, Y.; Nycholat, C.; Paulson, J.; Chen, X. “ Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling” J. Am. Chem. Soc. 140, 3592–3602 (2018).

Qin, W.; Qin, K.; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Zhou, Y.; Wang, C.; Chen, X. “Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling” Angew. Chem. Int. Ed. 57,1817-1820 (2018).

Du, Y.; Xie, R.; Sun, Y.; Fan, X.; Chen, X. “Liposome-Assisted Metabolic Glycan Labeling with Cell and Tissue Selectivity” Methods Enzymol. 598, 321-353 (2018).


Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.; Chen, X. “Quantitative time-resolved chemoproteomics reveals that stable O-GlcNAc regulates box C/D snoRNP biogenesis” Proc. Natl. Acad. Sci. USA 114, E6749–E6758 (2017).

Wang, W.; Zhu, Y.; Chen, X. “Selective Imaging of Gram-Negative and Gram-Positive Microbiotas in the Mouse Gut” Biochemistry 56, 3889-3893 (2017).

Zhu, Y.; Chen, X. “Expanding the Scope of Metabolic Glycan Labeling in Arabidopsis thaliana” ChemBioChem 18, 1286–1296 (2017).


Zhu, Q.; Venzke, D.; Walimbe, A. S.; Anderson, M. E.; Fu, Q.; Kinch, L. N.; Wang, W.; Chen, X.; Grishin, N. V.; Huang, N.; Yu, L.; Dixon, J. E.; Campbell, K. P.; Xiao J. “Structure of protein O-mannose kinase reveals a unique active site architecture” ELife 5, e22238 (2016).

Li, Z.; Zhu, Y.; Sun, Y.; Qin, K.; Liu, W.; Zhou, W.; Chen, X. “Nitrilase-Activatable Noncanonical Amino Acid Precursors for Cell-Selective Metabolic Labeling of Proteomes” ACS Chem. Biol. 11, 3273-3277 (2016).

Zhu, Y.; Wu, J.; Chen, X. “Metabolic Labeling and Imaging of N-Linked Glycans in Arabidopsis ThalianaAngew. Chem. Int. Ed 55, 9301-9305 (2016).

Xie, R.; Dong, L.; Du, Y.; Zhu, Y.; Hua, R.; Zhang, C.; Chen, X. “In Vivo Metabolic Labeling of Sialoglycans in the Mouse Brain By Using A Liposome-Assisted Bioorthogonal Reporter Strategy“ Proc. Natl. Acad. Sci. USA 113, 5173-5178 (2016).

Li, H.; Fan, X.; Chen, X. “Near-Infrared Light Activation of Proteins Inside Living Cells Enabled by Carbon Nanotube-Mediated Intracellular Delivery” ACS Appl. Mater. Interfaces 8, 4500-4507 (2016).

Cheng, B.; Xie, R.; Dong, L. Chen, X. “Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances” ChemBioChem 17, 11-27 (2016).


Lin, W.; Gao, L.; Chen, X. “Protein-Specific Imaging of O-GlcNAcylation in Single Cells” ChemBioChem 16, 2571-2575 (2015).

Lin, W.; Gao, L.; Chen, X. “Protein-Specific Imaging of Posttranslational Modifications” Curr. Opin. Chem. Biol. 28, 156-163 (2015).

Du, J.; Hong, S.; Dong, L.; Cheng, B.; Lin, L.; Zhao, B.; Chen, Y.; Chen, X. “Dynamic Sialylation in Transforming Growth Factor- β -Induced Epithelial to Mesenchymal Transition” J. Biol. Chem. 290, 12000-12013 (2015).

Lin, L.; Liu, L.; Zhao, B.; Xie, R.; Lin, W.; Li, H.; Shi, M.; Chen, Y.; Springer, T. A.; Chen, X. “Carbon Nanotube-Assisted Optical Activation of TGF- β Signaling by Near-Infrared Light” Nature Nanotech. 10, 465-471 (2015).

Wang, J.; Cheng, B.; Li, J.; Zhang, Z.; Hong, W.; Chen, X.; Chen, R. P. “ Chemical Remodeling of Cell-Surface Sialic Acids via Palladium-Triggered Bioorthogonal Elimination Reactions Angew. Chem. Int. Ed. 54, 5364-5368 (2015).

Hong, S.; Lin, L.; Xiao, M.; Chen, X. “Live-Cell Bioorthogonal Raman Imaging” Curr. Opin. Chem. Biol. 24, 91-96 (2015).


Xie, R.; Dong, L.; Huang, R.; Hong, S.; Lei, R.; Chen, X. “Targeted Imaging and Proteomic Analysis of Tumor-Associated Glycans in Living Animals” Angew. Chem. Int. Ed. 53, 14082-14086 (2014).

Rong, J.; Han, J.; Dong, L.; Tan, Y.; Yang, H.; Feng, L.; Wang, Q.; Meng, R.; Zhao, J.; Wang, S.; Chen, X. “Glycan Imaging in Intact Rat Hearts and Glycoproteomic Analysis Reveal the Upregulation of Sialylation during Cardiac Hypertrophy” J. Am. Chem. Soc. 136, 17468-17476 (2014).

Xiao, M.; Lin, L.; Li, Z.; Liu, J.; Hong, S.; Li, Y.; Zheng, M.; Duan, X.; Chen, X. “SERS Imaging of Cell-Surface Biomolecules Metabolically Labeled With Bioorthogonal Raman Reporters” Chem. Asian J. 9, 2040-2044 (2014).

Hong, S.; Chen, T.; Zhu, Y.; Li, A.; Huang, Y.; Chen, X. “ Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules” Angew. Chem. Int. Ed. 53, 5827-5831 (2014).

Lin, W.; Du, Y.; Zhu, Y.; Chen, X. “A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans” J. Am. Chem. Soc. 136, 679-687 (2014).


Li, S.; Zhang, L.; Yao, Q.; Li L.; Dong, N.; Rong, J.; Gao, W.; Ding, X.; Sun, L.; Chen, X.; Chen, S.; Shao, F. “Pathogen Blocks Host Death Receptor Signalling by Arginine GlcNAcylation of Death Domains” Nature 501, 242-246 (2013).

Xie, R.; Hong, S.; Chen, X. “Cell-selective Metabolic Labeling of Biomolecules with Bioorthogonal Functionalities” Curr. Opin. Chem. Biol. 17, 747-752 (2013).

Feng, L.; Hong, S.; Rong, J.; You, Q.; Dai, P.; Huang, R.; Tan, Y.; Hong, W.; Xie, C.; Zhao, J.; Chen, X. “Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans” J. Am. Chem. Soc. 135, 9244-9247 (2013).

Lin, L.; Tian, X.; Hong, S.; Dai, P.; You, Q.; Wang, R.; Feng, L.; Xie, C.; Tian, Z.; Chen, X. “A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells.” Angew. Chem. Int. Ed. 52, 7266-7271 (2013).

Zhang, C.; Yin, A.; Jiang, R.; Rong, J.; Dong, L.; Zhao, T.; Sun, L.; Wang, J.; Chen, X.; Yan, C.; “ Time-Temperature Indicator for Perishable Products Based on Kinetically Programmable Ag Overgrowth on Au Nanorods ACS Nano 7, 4561-4568 (2012).



Rouhanifard, S. H.; Xie, R.; Zhang, G.; Sun, X.; Chen, X.; Wu, P. “Detection and Isolation of Dendritic Cells Using Lewis X-Functionalized Magnetic Nanoparticles” Biomacromolecules 13, 3039-3045 (2012).

Xie, R.; Hong, S.; Feng, L.; Rong, J.; Chen, X. “Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes” J. Am. Chem. Soc. 134, 9914-9917 (2012).


Wang, W.; Hong, S.; Tran, A.; Triano, R.; Jiang, H.; Liu, Y; Chen, X.; Wu, P. “Sulfated Ligands for the Copper(I)-catalyzed Azide Alkyne Cycloaddition” Chem. Asian J. 6, 2796-2802 (2011).

Hao, Z.; Hong, S.; Chen, X.; Chen, R. P. “Introducing Bioorthogonal Functionalities into Proteins in Living Cells Acc. Chem. Res. 44, 742-751 (2011).

Prior to PKU

Chen, X.; Yu, Y.; Mi, L.; Walz, T.; Springer, T. A. “Molecular Basis for Complement Recognition by Integrin αXβ2” Proc. Natl. Acad. Sci. USA 109, 4586-4591 (2012).

Shi, M.; Zhu, J.; Wang, R.; Chen, X.; Mi, L.; Walz, T.; Springer, T. A. “Latent TGF-β Structure and Activation ” Nature 474, 343-349 (2011).

Chen, X.; Xie, C.; Nishida, N.; Li, Z.; Walz, T.; Springer, T. A. “Requirement of Open Headpiece Conformation for Activation of Leukocyte Integrin αXβ2” Proc. Natl. Acad. Sci. USA 107, 14727-14732 (2010).

Xie, C; Zhu, J.; Chen, X.; Lizhi Mi; Nishida, N.; Springer, T. A. “Structure of an integrin with an αI domain, complement receptor type 4” EMBO J. 29, 666-678 (2010).

Chang, P.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T; Bertozzi, C. R.; Wu, P.; “Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars” Angew. Chem. Int. Ed. 48, 4030-4033 (2009).

Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. “Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells” J. Am. Chem. Soc. 131, 890-891 (2009).

Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. “Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers” Angew. Chem. Int. Ed. 47, 5022-5055 (2008).

Chen, X.; Kis, A.; Zettl, A.; Bertozzi, C. R. “A Cell Nanoinjector Based on Carbon Nanotubes” Proc. Natl. Acad. Sci. USA 104, 8218-8222 (2007).

Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. “Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and their Display on Supported Bilayers” J. Am. Chem. Soc. 129, 5462-5471 (2007).

Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R. “Interfacing Carbon Nanotubes with Living Cells” J. Am. Chem. Soc. 128, 6292-6293 (2006).

Chen, X.; Lee G. S.; Zettl A.; Bertozzi, C. R. “Biomimetic Engineering of Carbon Nanotubes Using Cell Surface Mucin Mimics” Angew. Chem. Int. Ed. 43, 6111-6116 (2004).

Sun, X.; Chen, X.; Li, Y. “A CTAB-Assisted Hydrothermal Orientation Growth of ZnO Nanorods” Mater. Chem. Phys. 78, 99-104 (2003).

Sun, X.; Chen, X.; Li, Y. “Large-Scale Synthesis of Sodium and Potassium Titanate” Inorg. Chem. 41, 4996-4998 (2002).

Sun, X.; Chen, X.; Li, Y. “Evaporation Growth of Multipod ZnO Whisker Assisted by A Cu2+ Etching Technique” J. Crystal. Growth. 244, 218-223 (2002).

Chen, X.; Sun, X.; Li, Y. “Self-Assembling Vanadium Oxide Nanotubes by Organic Molecular Templates” Inorg. Chem. 41, 4524-4530 (2002).

Chen, X.; Deng, Z.; Li, Y.; Li, Y. “Hydrothermal Synthesis and Superparamagnetic Behaviors of A Series of Ferrite Nanoparticles” Chin. J. Inorg. Chem. 18, 460-464 (2002).

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