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Jiahua Chen

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Jiahua Chen
EDUCATION
1985-1988 Ph.D. Peking University
1982-1985 M.S.  Peking University
1978-1982 B.S.  Peking University
CURRENT RESEARCH
Chemical genetic research Chemical genetic approach is a unique tool for us to understanding the important biological events. My group, cooperated with other biology terms, focuses on the investigation of some viral targets by using the combinatorial synthesis of natural product-like small molecular libraries. The ultimate goal for our research is to establish a research platform for the students to expose an atmosphere of chemistry and biology
Construction of libraries of small organic molecules Combinatorial chemistry can be used to synthesize diversified molecules on a large scale. As with all large-scale experiments, this process requires a major investment in equipment, consumables and time. Therefore, careful design is critical. As the complexity of the libraries to be generated increases, additional considerations become important. What are the issues that should be considered when planning combinatorial chemistry projects? Which features in the design strategy are critical to consider ensuring that all of the potential products will be synthesized? How are the reactants selected to optimize product synthesis and yield? My group has involved a synthetic strategy which incorporates a number of critical components into a tightly controlled process that generates molecules with maximal structural complexity.
RESEARCH EXPERIENCE
1998 - 2001 Associate Professor, Chemistry Department, Peking University.(Design and synthesis of  antigen; preparation of catalytic antibody)
1996 - 1997 Visiting Scholar, Department of Chemistry, McGill University, Canada.(Synthesis of branched oligonucleotides)
1991 - 1995 Senior engineer, Beijing Inst.of Chemical Reagents, Beijing, China.(Research and development of antibodies and diagnostic kits)
1988 - 1991 Engineer, Beijing Inst.of Chemical Reagents, Beijing, China.(Organic process research & development)
1985 - 1985 Chem. Dept., PKU, Beijing, China.(Kinetic study of volatile components in plant)
1982 - 1985 Chem. Dept., PKU, Beijing, China.(Separation and Identification of volatile components in fresh flowers;synthesis of a precursor of some drugs)
2010 Wuxi Pharma Life Science Excellence Award (Golden Metal)
SELECTIVE PUBLICATIONS
1. Diastereoselective Total Synthesis of (±)-Schindilactone A
  Q. Xiao, W. W. Ren, Z. X. Chen, T. W. Sun, Y. Li, Q. D. Ye, J. X. Gong, F. K. Meng, L.You, Y. F. Liu, M. Z. Zhao, L. M. Xu, Z. H. Shan, Y. Shi, Y. F. Tang, J. H. Chen, Yang, Z.
  Angew. Chem. Int. Ed. 2011, 50, 7373.
2. Asymmetric Total Synthesis and Structural Elucidation of NFAT-68
  L. Wang, Y. M. Xi, S. L. Yang, R. Zhu, Y. F. Liang, J. H. Chen, Yang, Z.
  Org. Lett. 2011, 13, 74.
3. An Unprecedented Silver Salt Effect Switches the Facial Selectivity in the Vinylogous Mukaiyama Aldol Reaction
  Y. F. Liang, L. Wang, R. Zhu, L. J. Deng, Y. F. Yang, J. M. Quan, J. H. Chen, Z. Yang
  Adv. Synth. Catal. 2010, 352, 2387.
4. Direct Imidation to Construct 1H-Benzo[d]imidazole through Pd(II)-Catalyzed C-H Activation Promoted by Thiourea
  Q. Xiao, W. Wang, G. Liu, F. K. Meng, J. H. Chen, Z. Yang, Z. J. Shi
  Chem. Eur. J. 2009, 15,7292.
5. Formal Total Synthesis of N-Methylmaysenine
  L. Wang, J. X. Gong, L. J. Deng, Z. Xiang, Z. X. Chen, Y. Wang, J. H. Chen, Z. Yang,
  Org. Lett. 2009, 11, 1809.
6. A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives
  N. D. Wang, J. Xiang, Z. Ma, J. M. Quan, J. H. Chen, Z. Yang
  J. Comb. Chem. 2008, 10, 825.
7. Steteoselective Construction of an Unprecedented 7-8 Fused Ring System in Micrandilactone A by [3,3]-Sigmatropic Rearrangement
  Y. D. Zhang, W. Ren, Y. Lan, Q. Xiao, K. Wang, J. Xu, J. H. Chen, Z. Yang
  Org. Lett. 2008, 10, 665.
8. Effect of LiCl on Tuning the Reactivity of Pd-TMTU Catalyzed Pauson-Khand Reactions
  L. J. Deng, J. Liu, J. Q. Huang, Y. Hu, M. Chen, Y. Lan, J. H. Chen, A. Lei, Z. Yang
  Synthesis 2007, 2565.
9. An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions
  Q. Xiao, W. W. Ren, Z. X. Chen, T. W. Sun, Y. Li, Q. D. Ye, J. X. Gong, F. K. Meng, L.You, Y. F. Liu, M. Z. Zhao, L. M. Xu, Z. H. Shan, Y. Shi, Y. F. Tang, J. H. Chen, Yang, Z.
  Angew. Chem. Int. Ed. 2011, 50, 7373.
10. Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene-Ene RCM
  Lu, K.; Huang, M.; Xiang, Z.; Liu, Y.; Chen, J.; Yang, Z.
  Org. Lett. 2006, 8, 1193.
11. Synthetic Study of 1,3-Butadiene-Based IMDA Approach to Construct a [5-7-6]  Tricyclic Core and Its Application to the Total Synthesis of C8-epi-Guanacastepene O
  Li, C. ; Wang, C. ; Liang, B. ; Zhang, X. ; Deng, L. ; Liang, S. ; Chen, J. ; Wu, Y. ; Yang, Z.
  J. Org. Chem. 2006, 71, 6892.
12. Synthesis of Functionalized Quinolines via Ugi and Pd-Catalyzed Intramolecular Arylation Reactions
  Zhibo Ma, Zheng Xiang, Tuoping Luo, Kui Lu, Zhibin Xu, Jiahua Chen, Zhen Yang
  J.Comb. Chem. 2006; 8(5); 696-704.
13. Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A
  Yan-Dong Zhang, Ye-Feng Tang, Tuo-Ping Luo, Juan Shen, Jia-Hua Chen, and Zhen Yang
  Org. Lett., 2006, 8, 107-110
14. Thioureas as Ligands in the Pd-Catalyzed Intramolecular Pauson-Khand Reaction
  Tang, Y.; Deng, L.; Zhang, Y.; Dong, G.; Chen, J.; Yang, Z.
  Org. Lett. 2005, 7, 1657.
15. A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation
  Tang, Y.; Zhang, Y.; Dai, M.; Luo, T.; Deng, L.; Chen, J.; Yang, Z.
  Org. Lett. 2005, 7, 885-888.
16. A Concise and Diversity-Oriented Strategy for the Synthesis of Benzofurans and Indoles via Ugi and Diels-Alder Reactions
  Kui Lu, Tuoping Luo, Zheng Xiang, Zejin You, Reza Fathi, Jiahua Chen and Zhen Yang
  J. Comb. Chem. 2005, 7, 958-967
17. Exploring an Expedient IMDA Reaction Approach to Construct the Guanacastepene Core
  Chuang-Chuang Li,Shuang Liang, Xin-Hao Zhang, Zhi-Xiang Xie, Jia-Hua Chen, Yun-Dong Wu, and Zhen Yang
  Org.Lett. 2005, 17, 3709-3712
18. Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as Solvent
  Bo Liang, Mengwei Huang, Zejin You, Zhengchang Xiong, Kui Lu, Reza Fathi, Jiahua Chen, and Zhen Yang
  J. Org. Chem. 2005, 70, 6097-6100
19. Copper-Free Sonogashira Coupling Reaction with PdCl2 in –Water under Aerobic Conditions
  Bo Liang, Mingji Dai, Jiahua Che, and Zhen Yang
  J. Org. Chem. 2005, 70, 391-393
20. Tetramethyl Thiourea/CO2(CO)8-Catalyzed Pauson-Khand Reaction under Balloon Pressure of CO
  Yefeng Tang, Lujiang Deng, Yandong Zhang, Guangbin dong, Jiahua Chen, and Zhen Yang
  Org.Lett. 2005, 7, 593-595
21. A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions
  Mingji Dai, Bo Liang, Cuihua Wang, Zejin You, Jing Xiang, Guangbin Dong, Jiahua Chen, Zhen Yang
  Adv. Synth. Catal. 2004, 346, 1-6