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Updated 2018-03-26
All Rights Reserved
By Cai Yuan-Bo, Xie Da, Yin Hao-Yan@Metheads
CCME PKU 2008-2017
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Reasearch Interests : |
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| 1. Porphyrin and Porpholactone Chemistry | |
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Porphyrins are organic molecules which play crucial roles in redox reactions in nature. As a macrocycle molecule, the 18-π electronic structure provides porphyrins with stability and good photophysical properties. In our group, we try to use different methods to modify and derivate the traditional structure of porphyrins to improve their photophysical properties and expand their functions. Porpholactone is one of the porphyrin derivatives we focus on. Its lactone structure in one of the pyrrole rings provides a very good place to do functionalization, while the change in the backbone structure without destructing the 18-π structure gives porpholactone new chemical properties for us to explore. We challenge ourselves in developing medical reagents such as MRI contrast reagents and photodynamic therapeutic reagents, fluorescent sensors and catalysts to make good use of the unusual structure of porpholactone. |
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Related paper: Liang. L., Lv. H.-B., Yu. Y., Wang. P., Zhang. J.-L.*, Dalton Trans., 2012, 41, 1457 |
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| 2. Metal-Salen Complexes and Its Applications in Bioimaging and Sensor Design | |
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Compared with traditional organic fluorescent dyes, fluorescent dyes based on zinc salen comlexes bear advantages of high quantum yield, high stability, low cytotoxity and so forth. The zinc salen complexes we developed also has subcellular structure selectivity and the excitation via two photon process, which are impressive qualities to give potential application. At present, we are focusing on metal-salen based sensor design and taking advantage of the nice qualities of zinc salen complexes to observe and study cellular events. |
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Related Work: Hai. Y., Cheng. J.-J., Zhao. P., Lv. H.-B., Yu. Y., Xu. P.-Y.*, Zhang. J.-L.*, Chem. Commun., 2011, 47, 2435 |
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| 3. Design of Artificial Metalloenzymes | |
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| As delicate articrafts designed by the nature, enzymes have long been attractive to chemists. It is fascinating to design artificial enzymes to expand the traditional catalysis scope of natural enzymes. Trying to combine organic and inorganic synthesis together with molecular biology approach in this project, we do mutations to adjust scaffolds of the artificial enzymes provided by natural proteins, and synthesize transition metal complexes as artificial metal cofactor to get semi-synthesized artificial metalloenzymes. Taking advantages of both selectivity and hydrophobicity of protein scaffold as well as powerful catalytic center provided by transition metal complexes, it is attractive to develop applications of artificial enzymes in organic catalysis and small molecule activation. | |
| Related Work: Garner. D. K., Liang. L., Barrios. D. A., Zhang. J.-L.*, Lu. Y.*, ACS Catal., 2011, 1, 1083 | |