News
2025.5.17
Congratulations to Yi Zhang on the successful publication of her paper "Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages" in Nature Communications.
Abstract
Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we develop a universal system for dynamic metabolomics by stable isotope tracing at the single-cell level. This system comprises a high-throughput single-cell data acquisition platform and an untargeted isotope tracing data processing platform, providing an integrated workflow for dynamic metabolomics of single cells. This system enables the global activity profiling and flow analysis of interlaced metabolic networks at the single-cell level and reveals heterogeneous metabolic activities among single cells. The significance of activity profiling is underscored by a 2-deoxyglucose inhibition model, demonstrating delicate metabolic alteration within single cells which cannot reflected by concentration analysis. Significantly, the system combined with a neural network model enables the metabolomic profiling of direct co-cultured tumor cells and macrophages. This reveals intricate cell-cell interaction mechanisms within the tumor microenvironment and firstly identifies versatile polarization subtypes of tumor-associated macrophages based on their metabolic signatures, which is in line with the renewed diversity atlas of macrophages from single-cell RNA-sequencing. The developed system facilitates a comprehensive understanding single-cell metabolomics from both static and dynamic perspectives.
2025.1.8
Congratulations to Shaojie Qin on the publication of his paper "Multi-dimensional bio mass cytometry: simultaneous analysis of cytoplasmic proteins and metabolites on single cells" in Chemical Science.
2024.10.23
Congratulations to Shaojie Qin and Caiwei Hu for winning the Best Youth Oral Presentation Award and Best Poster Award, respectively, at HPLC 2024!
2024.6.5
Congratulations to Shaojie Qin on obtaining his doctoral degree! We also extend our warmest congratulations to Dr. Xue Zhang and Dr. Xiaodan Qiu on their successful completion of their postdoctoral programs!
2024.5.23
Congratulations to Shaojie Qin on the successful publication of his paper in Nature Communications
2024.3.20
Congratulations to Yi Zhang on the publication of her review article!
2023.8.17
Congratulations to Shaojie Qin for winning the Oral Presentation Prize at the ANLY Virtual Asia-Pacific Graduate Student Symposium, ACS Fall 2023!
