Accurate Single-Molecule Kinetic Isotope Effects

The combination of single-molecule electrical detection and kinetic isotope effect provides a powerful tool to determine the rate-determining step and accurately quantifying the transition state structure in a reaction, therefore establishing a novel approach for controlling the transition state by an electric field.

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Research Fields

One remarkable aspect in Chemistry is its powerful ability to create new materials; one remarkable aspect in Physics is its powerful ability to investigate the intrinsic properties of these materials, the combination of both enables us to reveal the details of nature and change nature. The research in our molecular materials and devices lab is focused on exploring the optoelectronic properties of novel functional molecular materials and/or low dimensional nanomaterials at the nanometer or molecular level, such as electron transport properties, optoelectronic properties and stimuli-responsive abilities. These materials include single organic molecules/molecular clusters, carbon nanotubes, organic/inorganic nanowires, graphene, biomacromolecules, nanoparticles, and so on. These are challenging and predictable but active and interdisciplinary frontier research areas with many opportunities and great potential applications. Graduate and postdoctoral students working on these projects will have been extensively well-trained in all aspects, including organic syntheses, assembly techniques, micro/nanofabrications, and detection systems. Specifically, our research focuses are listed below:

1. Nano/molecular electronics;

2. Single-molecule dynamics and detection;

3. Organic/flexible electronics;

4. Chemo/biosensors

News & Events


The article "Real-Time Direct Monitoring of Chirality Fixation and Recognition at the Single-Molecule Level" by Weilin Hu, Mingyao Li et al. was accepted by J. Am. Chem. Soc. 


The article "Direct Flipping Dynamics and Quantized Enrichment of Chirality at Single-Molecule Resolution" by Weilin Hu, Mingyao Li et al. was accepted by Sci. Adv. 


The article "Supramolecular Design and Assembly Engineering toward High-Performance Organic Field-Effect Transistors" by Mingliang Li et al. was accepted by Acc. Mater. Res.


The article "Understanding Emergent Complexity from a Single-Molecule Perspective" by Yilin Guo, Mingyao Li et al. was accepted by JACS Au


The article "Regulation of Quantum Spin Conversions in a Single Molecular Radical" by Caiyao Yang et al. was accepted by Nat. Nanotechnol. .


The article "Logic Operation and Real-Time Communication via Tunable Excited States in a Single-Molecule Optoelectronic Chip" by Chen Yang, Yilin Guo et al. was accepted by Chem.


The article "Polaron Interfacial Entropy as a Route to High Thermoelectric Performance in DAE-Doped PEDOT: PSS Films" by Jiajia Zhang et al. was accepted by Natl. Sci. Rev..


The article "Single-Molecule Non-Volatile Memories: An Overview and Future Perspective" by Wei Si, Junhao Li et al. was accepted by J. Mater. Chem. C.


The article "The role of halogens in Au-S bond cleavage for energy-differentiated catalysis at the single-bond limit" by Peihui Li et al. was accepted by Nat. Commun..



The article "Precise detection, control and synthesis of chiral compounds at single-molecule resolution" by Chen Yang, Weilin Hu and Xuefeng Guo was accepted by Nano-Micro Lett..


The article "Visualizing single-molecule conformational transition and binding dynamics of intrinsically disordered proteins" by Wenzhe Liu et al. was accepted by Nat. Commun..


The article  "Monitoring Molecular Dynamics with Single-Molecule Electronic devices and Fluorescence Techniques" by Lan Yang et al. was accepted by Chin. J. Chem.