Accurate Single-Molecule Kinetic Isotope Effects

The combination of single-molecule electrical detection and kinetic isotope effect provides a powerful tool to determine the rate-determining step and accurately quantifying the transition state structure in a reaction, therefore establishing a novel approach for controlling the transition state by an electric field.

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Research Fields

One remarkable aspect in Chemistry is its powerful ability to create new materials; one remarkable aspect in Physics is its powerful ability to investigate the intrinsic properties of these materials, the combination of both enables us to reveal the details of nature and change nature. The research in our molecular materials and devices lab is focused on exploring the optoelectronic properties of novel functional molecular materials and/or low dimensional nanomaterials at the nanometer or molecular level, such as electron transport properties, optoelectronic properties and stimuli-responsive abilities. These materials include single organic molecules/molecular clusters, carbon nanotubes, organic/inorganic nanowires, graphene, biomacromolecules, nanoparticles, and so on. These are challenging and predictable but active and interdisciplinary frontier research areas with many opportunities and great potential applications. Graduate and postdoctoral students working on these projects will have been extensively well-trained in all aspects, including organic syntheses, assembly techniques, micro/nanofabrications, and detection systems. Specifically, our research focuses are listed below:

1. Nano/molecular electronics;

2. Single-molecule dynamics and detection;

3. Organic/flexible electronics;

4. Chemo/biosensors

News & Events

2025-04-23

The article “Nanosecond-scale single-molecule reaction dynamics for scalable synthesis on a chip” by Chen Yang, Shuyao Zhou, and Yilin Guo was accepted by Natl. Sci. Rev.

2025-04-09

The article “A robust single-molecule diode with high rectification ratio and integrability” by Yilin Guo, Chen Yang, and Shuyao Zhou was accepted by J. Am. Chem. Soc.

 

2025-03-25

The article “Stereochemistry at the Single-Molecule Level: From Monitoring to Regulation” by Wenlong Cai, Xinmiao Xie, Zezhou Yang, and Xuefeng Guo was accepted by Angew. Chem. Int. Ed. 

2025-02-27

The article “Single-Molecule Solvolysis Reaction Dynamics under Electrostatic Catalysis and Proton Tunneling” by Xinmiao Xie, Jiajia Yang, Yong Yan et al. was accepted by Angew. Chem. Int. Ed.

2025-01-27

The article “Mechanism of Hydrogen Generation Catalyzed by a Single Atom and Its Spin Regulation” by Mingyao Li, Weilin Hu et al. was accepted by J. Am. Chem. Soc.

2025-01-01

The article “Emergent Complexity of Quantum Rotation Tunneling” by Yilin Guo, Chen Yang, and Xinmiao Xie was accepted by Sci. Adv.

2024-12-17

The article "Quasi-Continuous Efficient Regulation of Single-Molecule Electronic Distribution" by Zhizhou Li, Weilin Hu and Shuyao Zhou was accepted by Adv. Sci.

2024-11-12

The article "The Utilization of Electric Fields to Modulate Molecular Activities on the Nanoscale: From Physical Properties to Chemical Reactions" by Chen Yang, Yilin Guo and Heng Zhang was accepted by Chem. Rev.

2024-11-07

The article "Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single-Molecule Conductance" by Lihua Zhao et al. was accepted by Adv. Sci.

2024-10-09

The article "Exceptional Field Effect and Negative Differential Conductance in Spiro-conjugated Single-Molecule Junctions" by Caiyao Yang, Jiawen Cao et al. was accepted by J. Am. Chem. Soc.

2024-09-26


The article "Full On-Device Manipulation of Olefin Metathesis for Precise Manufacturing" by Yilin Guo, Chen Yang et al. was accepted by Nat. Nanotechnol.

 

2024-06-30

The article "Single-Molecule Functional Chips: Unveiling the Full Potential of Molecular Electronics and Optoelectronics" by Heng Zhang, Junhao Li et al. was accepted by Acc. Mater. Res.