Accurate Single-Molecule Kinetic Isotope Effects

The combination of single-molecule electrical detection and kinetic isotope effect provides a powerful tool to determine the rate-determining step and accurately quantifying the transition state structure in a reaction, therefore establishing a novel approach for controlling the transition state by an electric field.

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Research Fields

One remarkable aspect in Chemistry is its powerful ability to create new materials; one remarkable aspect in Physics is its powerful ability to investigate the intrinsic properties of these materials, the combination of both enables us to reveal the details of nature and change nature. The research in our molecular materials and devices lab is focused on exploring the optoelectronic properties of novel functional molecular materials and/or low dimensional nanomaterials at the nanometer or molecular level, such as electron transport properties, optoelectronic properties and stimuli-responsive abilities. These materials include single organic molecules/molecular clusters, carbon nanotubes, organic/inorganic nanowires, graphene, biomacromolecules, nanoparticles, and so on. These are challenging and predictable but active and interdisciplinary frontier research areas with many opportunities and great potential applications. Graduate and postdoctoral students working on these projects will have been extensively well-trained in all aspects, including organic syntheses, assembly techniques, micro/nanofabrications, and detection systems. Specifically, our research focuses are listed below:

1. Nano/molecular electronics;

2. Single-molecule dynamics and detection;

3. Organic/flexible electronics;

4. Chemo/biosensors

News & Events


The article "Precise detection, control and synthesis of chiral compounds at single-molecule resolution" by Chen Yang, Weilin Hu and Xuefeng Guo was accepted by Nano-Micro Lett..


The article "Visualizing single-molecule conformational transition and binding dynamics of intrinsically disordered proteins" by Wenzhe Liu et al. was accepted by Nat. Commun..


The article  "Monitoring Molecular Dynamics with Single-Molecule Electronic devices and Fluorescence Techniques" by Lan Yang et al. was accepted by Chin. J. Chem.


The article “Distinct Armchair and Zigzag Charge Transport through Single Polycyclic Aromatics” by Miao Zhang et al. was accepted by Sci. Adv. .


The article “Stimuli-Induced Subconformation Transformation of the PSI-LHCI Protein at Single-Molecule Resolution” by Zhiheng Yang, Jie Wang et al. was accepted by Adv. Sci. .


Congratulations! The article "Dual-gated single-molecule field-effect transistors beyond Moore's law" was one of the most read articles (Top 25) in physics among more than 7,900 articles published in Nature Communications in 2022, demonstrating its significance and valuable contribution to the research community.


The article “Exploring electronic characteristics of acceptor-donor-acceptor type molecules by single-molecule charge transport” by Peihui Li , Wan Xiong, Jinying Wang, and Jie Hao et al. was accepted by Adv. Mater..


The highlight “Single-Molecule Conductance Measurements Reveal a New Catalytic Mechanism of Formate Dehydrogenase” by Shichao Zhong et al. was accepted by Sci China Chem.


The article “Tunable Interferometric Effects between Single-molecule Suzuki-Miyaura Cross-couplings” by Yilin Guo and Chen Yang et al. was accepted by J. Am. Chem. Soc..



The article "Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity" by Chen Yang et al. was accepted by Nat. Chem..


The book "Interface Engineering in Organic Field-Effect Transistors" by Xuefeng Guo and Hongliang Chen was accepted by Wiley-VCH.


The article "Single-Molecule Electronic Biosensors: Principles and Applications" by Xinyue Chang et al. was accepted by Adv. Sensor Res..