Accurate Single-Molecule Kinetic Isotope Effects

The combination of single-molecule electrical detection and kinetic isotope effect provides a powerful tool to determine the rate-determining step and accurately quantifying the transition state structure in a reaction, therefore establishing a novel approach for controlling the transition state by an electric field.

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Research Fields

One remarkable aspect in Chemistry is its powerful ability to create new materials; one remarkable aspect in Physics is its powerful ability to investigate the intrinsic properties of these materials, the combination of both enables us to reveal the details of nature and change nature. The research in our molecular materials and devices lab is focused on exploring the optoelectronic properties of novel functional molecular materials and/or low dimensional nanomaterials at the nanometer or molecular level, such as electron transport properties, optoelectronic properties and stimuli-responsive abilities. These materials include single organic molecules/molecular clusters, carbon nanotubes, organic/inorganic nanowires, graphene, biomacromolecules, nanoparticles, and so on. These are challenging and predictable but active and interdisciplinary frontier research areas with many opportunities and great potential applications. Graduate and postdoctoral students working on these projects will have been extensively well-trained in all aspects, including organic syntheses, assembly techniques, micro/nanofabrications, and detection systems. Specifically, our research focuses are listed below:

1. Nano/molecular electronics;

2. Single-molecule dynamics and detection;

3. Organic/flexible electronics;

4. Chemo/biosensors

News & Events


The highlight “Single-Molecule Conductance Measurements Reveal a New Catalytic Mechanism of Formate Dehydrogenase” by Shichao Zhong et al. was accepted by Sci China Chem.


The article “Tunable Interferometric Effects between Single-molecule Suzuki-Miyaura Cross-couplings” by Yilin Guo and Chen Yang et al. was accepted by J. Am. Chem. Soc..



The article "Stereochemistry Identified by Single-Molecule Chirality-Induced Spin Selectivity" by Chen Yang et al. was accepted by Nat. Chem..


The book "Interface Engineering in Organic Field-Effect Transistors" by Xuefeng Guo and Hongliang Chen was accepted by Wiley-VCH.


The article "Single-Molecule Electronic Biosensors: Principles and Applications" by Xinyue Chang et al. was accepted by Adv. Sensor Res..


The article "Single-Exonuclease Nanocircuits Reveal the RNA Degradation Dynamics of PNPase and Demonstrate Potential for RNA Sequencing" by Zhiheng Yang and Wenzhe Liu et al. was accepted by Nat. Commun..


The article "A Tunable Single-Molecule Light-Emitting Diode with Single-Photon Precision" by Chen Yang and Yilin Guo et al. was accepted by Adv. Mater..


The article "Opportunities and Challenges of Single Molecule Science" by Li Cheng et al. was accepted by Chinese Science Bulletin.


The article "Dipole-modulated charge transport through PNP-type single-molecule junctions" by Mingyao Li and Huanyan Fu et al. was accepted by J. Am. Chem. Soc..



The article “Vibration-Assisted Charge Transport through Positively Charged Dimer Junctions” by Xin Zhu et al. was accepted by Angew. Chem. Int. Ed..


The article “Quantum interference-controlled conductance enhancement in stacked graphene-like dimers” by Peihui Li , Songjun Hou, and Bader Alharbi et al. was accepted by J. Am. Chem. Soc..


The article “Novel properties of single molecules and their regulation” by Weilin Hu, Xuefeng Guo was accepted by Journal of Beijing Normal University (Natural Science).