High-Performance Monolayer Field-Effect Transistors with Aqueous Stability and High Sensitivity

Low-voltage, low-cost, high-performance monolayer field-effect transistors that comprise a densely-packed, long-range ordered monolayer, spin-coated from core-cladding liquid-crystalline pentathiophenes, and a solution-processed high-k HfO2-based nanoscale gate dielectric have been developed. These monolayers are light-sensitive and are able to function as reporters to convert analyte binding events into electrical signals with ultrahigh sensitivity (ca. 10 ppb).

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Research Fields

One remarkable aspect in Chemistry is its powerful ability to create new materials; one remarkable aspect in Physics is its powerful ability to investigate the intrinsic properties of these materials, the combination of both enables us to reveal the details of nature and change nature. The research in our molecular materials and devices lab is focused on exploring the optoelectronic properties of novel functional molecular materials and/or low dimensional nanomaterials at the nanometer or molecular level, such as electron transport properties, optoelectronic properties and stimuli-responsive abilities. These materials include single organic molecules/molecular clusters, carbon nanotubes, organic/inorganic nanowires, graphene, biomacromolecules, nanoparticles, and so on. These are challenging and predictable but active and interdisciplinary frontier research areas with many opportunities and great potential applications. Graduate and postdoctoral students working on these projects will have been extensively well-trained in all aspects, including organic syntheses, assembly techniques, micro/nanofabrications, and detection systems. Specifically, our research focuses are listed below:

1. Nano/molecular electronics;

2. Single-molecule dynamics and detection;

3. Organic/flexible electronics;

4. Chemo/biosensors

News & Events


Congratulations to Chen Yang for receiving the National Scholarship and Chem Star.


The article "Real-Time Observation of the Dynamics of an Individual Rotaxane Molecular Shuttle Using a Single Molecule Junction" by Dingkai Su et al. was accepted by Chem.


The article "Complete Mapping of DNA-Protein Interactions at the Single-Molecule Level" by Wenzhe Liu et al. was accepted by Adv. Sci..



The article "Principles of Molecular Machines at the Single-Molecule Scale" by Zhizhou Li et al. was accepted by ACS Materials Lett..



The article "Unveiling the Full Reaction Path of the Suzuki-Miyaura Cross-Coupling in a Single Molecule Junction" by Chen Yang and Lei Zhang et al. was accepted by Nat. Nanotechnol..


The article "Single-Molecule Electrical Spectroscopy of Organocatalysis" by Chen Yang and Lei Zhang et al. was accepted by Matter.


The article"Atomically Precise Engineering of Single-Molecule Stereoeletronic Effect" by Linan Meng and Na Xin et al. was accepted by Angew. Chem. Int. Ed..


The article "A Single-Molecule Electrical Approach for Amino Acid Detection and Chirality Recognition" by Zihao Liu et al. was accepted by Science Advances.


The article "Electric field-catalyzed single-molecule Diels-Alder reaction dynamics" by Chen Yang et al. was accepted by Science Advances.



The article"Unravelling structural dynamics within a photoswitchable single-peptide: A step towards multi-modal bio-inspired nanodevices" by Xinjiani Chen et al. was accepted by Angew. Chem. Int. Ed .


The book"Molecular-Scale Electronics: Concept, Fabrication and Applications" by Xuefeng Guo et al. was published by Wiley-VCH.


The article "Interface Engineering in Organic Field-Effect Transistors: Principles, Applications, and Perspectives" by Hongliang Chen et al. was accepted by Chemical Reviews.