Classical reaction-diffusion paradigm was found to break down in enzyme systems and common chemical reactions. Reaction and mobility were found coupled at the nanoscale. The mobility of reactants and the nearby solvent is more rapid than Brownian diffusion when the energy release rate exceeds a threshold. Delicately designed microfluidics experiments indicated that molecules in reaction gradients were observed to migrate “uphill” in the direction of lesser diffusivity as predicted by active matter theory. Scaling analysis of boosted fraction indicates the importance of long-range hydrodynamic coupling at the nanoscale. Many more efforts are to be devised to fully understand this phenomenon including coupling mechanism and how to exploit the maximal boost for efficient, economic synthesis and nanomachine engineering. We are interested in using fluorescence correlation spectroscopy, nuclear magnetic resonance spectroscopy, and liquid-phase electron microscopy to understand these active chemical systems, from molecular scale (small molecule reactions), to tenths nanometer systems (enzymes and reaction network), and to hundred-nanometer biological organizations (organelles).