. The Wang Lab

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | Pre-PKU


33.   Chen, Y.; Qin, W.; Li, Z.; Guo, Z.; Liu, Y.; Lan, T.; Wang, C.*, Site-specific chemoproteomic profiling of targets of glyoxal. Future medicinal chemistry 2019, doi:10.4155/fmc-2019-0221.

32.  Qin, W.; Xie, Z.; Wang, J.; Ou, G.; Wang, C.*; Chen, X.*, Chemoproteomic profiling of O-GlcNAcylation in caenorhabditis elegans. Biochemistry 2019, doi:10.1021/acs.biochem.9b00622.

31.   Qin, W.; Qin, K.; Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou, W.; Wang, Y. L.; Chen, X.*; Wang, C.*, S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10), 983-991.

30.   Liu, F.; Wang, H.; Li, S.; Bare, G. A. L.; Chen, X.; Wang, C.; Moses, J. E.; Wu, P.*; Sharpless, K. B.*, Biocompatible SuFEx click chemistry: thionyl tetrafluoride (SOF4)-derived connective hubs for bioconjugation to DNA and proteins. Angew. Chem. Int. Ed. Engl. 2019, 58 (24), 8029-8033.

29.   Resnick, E.; Bradley, A.; Gan, J.; Douangamath, A.; Krojer, T.; Sethi, R.; Geurink, P. P.; Aimon, A.; Amitai, G.; Bellini, D.; Bennett, J.; Fairhead, M.; Fedorov, O.; Gabizon, R.; Gan, J.; Guo, J.; Plotnikov, A.; Reznik, N.; Ruda, G. F.; Diaz-Saez, L.; Straub, V. M.; Szommer, T.; Velupillai, S.; Zaidman, D.; Zhang, Y.; Coker, A. R.; Dowson, C. G.; Barr, H. M.; Wang, C.; Huber, K. V. M.; Brennan, P. E.; Ovaa, H.; von Delft, F.; London, N.*, Rapid covalent-probe discovery by electrophile-fragment screening. J. Am. Chem. Soc. 2019, 141 (22), 8951-8968.

28.   Wang, J.#; Liu, Y.#; Liu, Y.#; Zheng, S.; Wang, X.; Zhao, J.; Yang, F.; Zhang, G.; Wang, C.*; Chen, P. R.*, Time-resolved protein activation by proximal decaging in living systems. Nature 2019, 569 (7757), 509-513.

27.   Chen, N.#; Qiao, Z.#; Wang, C.*, A chemoselective reaction between protein N-homocysteinylation and azides catalyzed by heme(ii). Chem. Commun. (Camb.) 2019, 55 (25), 3654-3657.

26.   Chen, Y.; Liu, Y.; Hou, X.; Ye, Z.; Wang, C.*, Quantitative and site-specific chemoproteomic profiling of targets of acrolein. Chem. Res. Toxicol. 2019, 32 (3), 467-473.



25.   Tang, H.#; Dai, Z.#; Qin, X.; Cai, W.; Hu, L.; Huang, Y.; Cao, W.; Yang, F.; Wang, C.; Liu, T.*, Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors. J. Am. Chem. Soc. 2018,140(41), 13253-13259.

24.   Chen, Z.#; Jiang, Z.#; Chen, N.#; Shi, Q.; Tong, L.; Kong, F.; Cheng, X.; Chen, H.; Wang, C.*; Tang, B.*, Target discovery of ebselen with a biotinylated probe. Chem. Commun. (Camb.) 2018,54(68), 9506-9509.

23.   Qin, K.#; Zhu, Y.#; Qin, W.; Gao, J.; Shao, X.; Wang, Y.-L.; Zhou, W.*; Wang, C.*; Chen, X.*, Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker. ACS Chem. Biol. 2018,13(8), 1983-1989.

22.   Gao, J.#; Yang, F.#; Che, J.; Han, Y.; Wang, Y.; Chen, N.; Bak, D. W.; Lai, S.; Xie, X.; Weerapana, E.; Wang, C.*, Selenium-Encoded Isotopic Signature Targeted Profiling. ACS Cent Sci 2018,4(8), 960-970.

21.   Yang, F.#; Gao, J.#; Che, J.; Jia, G.; Wang, C.*, A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomics. Anal. Chem. 2018,90(15), 9576-9582.

20.   Bak, D. W.*; Gao, J.; Wang, C.; Weerapana, E.*, A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome. Cell Chem Biol 2018,25(9), 1157-1167 e4.

19.   Liang, K.#; Li, N.#; Wang, X.; Dai, J.; Liu, P.; Wang, C.; Chen, X.-W.; Gao, N.*; Xiao, J.*, Cryo-EM structure of human mitochondrial trifunctional protein. Proc. Natl. Acad. Sci. U. S. A. 2018,115(27), 7039-7044.

18.   Ye, Z.#; Zhang, X.#; Zhu, Y.; Song, T.; Chen, X.; Lei, X.*Wang, C.*, Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol. Pharm.2018, 15 (6), 2413-2422. 

17.   Dai, J.; Liang, K.; Zhao, S.; Jia, W.; Liu, Y.; Wu, H.; Lv, J.; Cao, C.; Chen, T.; Zhuang, S.; Hou, X.; Zhou, S.; Zhang, X.; Chen, X.-W.; Huang, Y.; Xiao, R.-P.; Wang, Y.-L.; Luo, T.; Xiao, J.; Wang, C.*, Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.Proc. Natl. Acad. Sci. U. S. A.2018, 115 (26), E5896-E5905.

16.   Chen, Y.; Liu, Y.; Lan, T.; Qin, W.; Zhu, Y.; Qin, K.; Gao, J.; Wang, H.; Hou, X.; Chen, N.; Friedmann Angeli, J. P.; Conrad, M.; Wang, C.*, Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J. Am. Chem. Soc.2018, 140, 13, 4712-4720.  (This paper was selected as ACS Editors Choice and JACS Spotlights)

15.   Chen, N.; Liu, J.; Qiao, Z.; Liu, Y.; Yang, Y.; Jiang, C.; Wang, X.; Wang, C.*, Chemical proteomic profiling of protein N-homocysteinylation with a thioester probe. Chem. Sci., 2018, 9, 2826-2830. 

14.   Qin, W.#; Qin, K.#; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Wang, C.* and Chen, X.*, Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosacharides during Metabolic Glycan Labeling.Angew. Chem. Int. Ed. 2018, 57, 7, 1817-1820. (This work was selected as a Back Cover and a Very Important Paper)

13.   Wang, H.#; Chen, X.#; Li, C.#; Liu, Y.; Yang, F.; Wang, C.*,Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry2018, 57 (4), 451-460. (This paper was selected as ACS Editors Choice) 


12.   Li, X.#; Xiong, X.#; Zhang, M.#; Wang, K.#; Chen, Y.#; Zhou, J.; Mao, Y.; Lv, J.; Yi, D.; Chen, X. W.; Wang, C.; Qian, S. B.; Yi, C.*, Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Molecular cell 2017, 68, 1–13.

11.   Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.*; Chen, X.*, Quantitative time-resolved chemoproteomics reveals that stable O-GlcNAc regulates box C/D snoRNP biogenesis. Proc. Natl. Acad. Sci. U. S. A. 2017, 114 (33), E6749-e6758.

10.   Zhuang, S.#; Li, Q.#; Cai, L.; Wang, C.*; Lei, X.*, Chemoproteomic Profiling of Bile Acid Interacting Proteins. ACS Cent Sci 2017, 3 (5), 501-509.

9.    Chen, Y.; Cong, Y.; Quan, B.; Lan, T.; Chu, X.; Ye, Z.; Hou, X.; Wang, C.*, Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017, 12, 712-718.

8.    Liang, X.; Lv, F.; Wang, B.; Yu, K.; Wu, H.; Qi, Z.; Jiang, Z.; Chen, C.; Wang, A.; Miao, W.; Wang, W.; Hu, Z.; Liu, J.; Liu, X.; Zhao, Z.; Wang, L.; Zhang, S.; Ye, Z.; Wang, C.; Ren, T.; Wang, Y.; Liu, Q., Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)p henyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J. Med. Chem. 2017, 60 (5), 1793-1816.


7.    Chen, Y. ; Qin, W.; Wang, C.*, Chemoproteomic profiling of protein modifications by lipid-derived electrophiles. Curr. Opin. Chem. Biol. 2016, 30, 37-45.

6.    Yang, Y.; Song, H.; He, D.; Zhang, S.; Dai, S.; Lin, S.; Meng, R.; Wang, C.*; Chen, P. R.*, Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label. Nat. Commun. 2016, 7, 12299.

5.    Zhao, S.; Dai, J.; Hu, M.; Liu, C.; Meng, R.; Liu, X.; Wang, C.; Luo, T.*, Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling. Chem. Commun. (Camb.) 2016, 52 (25), 4702-5.

4.    Wang, A.#; Yan, X. E. #; Wu, H. #; Wang, W. #; Hu, C.; Chen, C.; Zhao, Z.; Zhao, P.; Li, X.; Wang, L.; Wang, B.; Ye, Z.; Wang, J.; Wang, C.; Zhang, W.; Gray, N. S.; Weisberg, E. L.; Chen, L.; Liu, J.*; Yun, C. H.*; Liu, Q.*, Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation. Oncotarget 2016, 7 (43), 69760-69769.


3.    Wu, H.#; Wang, A. #; Zhang, W. #; Wang, B. #; Chen, C. #; Wang, W.; Hu, C.; Ye, Z.; Zhao, Z.; Wang, L.; Li, X.; Yu, K.; Liu, J.; Wu, J.; Yan, X. E.; Zhao, P.; Wang, J.; Wang, C.; Weisberg, E. L.; Gray, N. S.; Yun, C. H.; Liu, J.*; Chen, L.*; Liu, Q.*, Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells. Oncotarget 2015, 6 (31), 31313-22.

2.    Wang, C.*; Chen, N., Activity-based Protein Profiling. Acta Chim. Sin. 2015, 73 (7), 657-668.


1.    Shannon, D. A.; Banerjee, R.; Webster, E. R.; Bak, D. W.; Wang, C.; Weerapana, E.*, Investigating the proteome reactivity and selectivity of aryl halides. J. Am. Chem. Soc. 2014, 136 (9), 3330-3.

Pre-PKU(selected publication):

10.   Wang, C.*; Weerapana, E.; Blewett, M. M.; Cravatt, B. F.*, A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nat. Methods 2014, 11 (1), 79-85.

9.     Rajagopalan, S.#; Wang, C.#; Yu, K.; Kuzin, A. P.; Richter, F.; Lew, S.; Miklos, A. E.; Matthews, M. L.; Seetharaman, J.; Su, M.; Hunt, J. F.; Cravatt, B. F.; Baker, D.*, Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat. Chem. Biol. 2014, 10 (5), 386-91.

8.     Dix, M. M.#; Simon, G. M. #; Wang, C.; Okerberg, E.; Patricelli, M. P.; Cravatt, B. F.*, Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell 2012, 150 (2), 426-40.

7.     Martin, B. R.*; Wang, C.; Adibekian, A.; Tully, S. E.; Cravatt, B. F.*, Global profiling of dynamic protein palmitoylation. Nat. Methods 2011, 9 (1), 84-9.

6.     Weerapana, E.#; Wang, C.#; Simon, G. M.; Richter, F.; Khare, S.; Dillon, M. B.; Bachovchin, D. A.; Mowen, K.; Baker, D.; Cravatt, B. F.*, Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature 2010, 468 (7325), 790-5.

5.     Wang, C.; Vernon, R.; Lange, O.; Tyka, M.; Baker, D.*, Prediction of structures of zinc-binding proteins through explicit modeling of metal coordination geometry. Protein Sci. 2010, 19 (3), 494-506.

4.     Wang, C.#; Schueler-Furman, O.#; Andre, I.; London, N.; Fleishman, S. J.; Bradley, P.; Qian, B.; Baker, D.*, RosettaDock in CAPRI rounds 6-12. Proteins 2007, 69 (4), 758-63.

3.     Wang, C.; Bradley, P.; Baker, D.*, Protein-protein docking with backbone flexibility. J. Mol. Biol. 2007, 373 (2), 503-19.

2.     Wang, C.#; Schueler-Furman, O.#; Baker, D.*, Improved side-chain modeling for protein-protein docking. Protein Sci. 2005, 14 (5), 1328-39.

1.     Schueler-Furman, O.#; Wang, C.#; Baker, D.*, Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility. Proteins 2005, 60 (2), 187-94.