Wgroup member: Dr. Yihua Hou Graduate student () Dr. Yihua Hou did intramolecular N-H insertion by Cu(II) mediated reaction of diazo compounds and application of Wolff rearrangement in g-lactam synthesis. Dr. Hou first joined Professor D. N. Harpp's group in McGill University and then Professor S. Hanessian's group in University of Montreal as postdoctoral fellow.

Ph.D thesis: The Reactions of alpha-Diazo Ketones Derived from Amino Acids

Publications

(1) Wolff Rearrangement of Diazoketones Derived from N-Tosyl Protected
a-Amino Acids and b-Amino Acids
Jianbo Wang and Yihua Hou J. Chem. Soc. Perkin Trans. 1, 1998, 1919-1924. Click Here

(2) Direct Trapping of Ketene Intermediates by Internal Nucleophile: A New
Approach for the Synthesis of g-Lactams
Yihua Hou and Jianbo Wang Chem. J. Chin. Univ. 1998, 19, No.8 (supplementary issue), 48.

(3) Synthesis of 4, 5, and 6-membered Aza Rings by Carbenoids Intramolecular N-H Insertion Catalyzed by Cu(acac)2
Yihua Hou, Peng Wu and Jianbo Wang J. Xiamen Univ. 1999, 38 (supplementary issue), 136.

(4) Application of Wolff Rearrangement in the Synthesis of Enantiomerically Pure 4,5-Disubstituted Pyrrolidinones
Yihua Hou,Peng Wu,Zhaohui Qu and Jianbo Wang J. Xiamen Univ. 1999, 38 (supplementary issue), 137.

(5) Stereoselective Synthesis of Enantiomerically Pure 4,5-Disubstituted
Pyrrolidinones from b-Amino Esters
Jianbo Wang, Yihua Hou, Peng Wu, Zhaohui Qu, and Albert S. C. Chan, Tetrahedron: Asymmetry, 1999, 10, 4553-4561. Click Here

(6) Intramolecular N-H Insertion of a-Diazocarbonyls Catalyzed by Cu(acac)2: An Efficient Route to the Derivatives of 3-Oxoazetidines, 3-Oxopyrrolidines and
3-Oxopiperidines
Jianbo Wang, Yihua Hou and Peng Wu, J. Chem. Soc. Perkin Trans. 1, 1999, 2277-2280. Click Here

(7) Copper(II) Chloride Dihydrate: A Catalytic Agent for the Deprotection of
Tetrahydropyranyl Ether (THP Ether) and 1-Ethoxyethyl Ether (EE Ether)
Jianbo Wang, Chao Zhang, Zhaohui Qu, Yihua Hou, Bei Chen, and Peng Wu, J. Chem. Res. 1999, 294-295. Click Here

(8) Development in the Research of Rh(II)-Mediated Carbenoids Intramolecular C-H Insertions (A review in Chinese)
Bei Chen,Fengting Liang,Yihua Hou,Jianbo Wang Chin. J. Org. Chem. 2000,20 (4): 433-440. Click Here