Wgroup member: Zhihua Ma Graduate student () Dr. Zhihua Ma's project was the development of new synthetic methods for chiral beta-amino acids. He discovered highly diastereoselective addition of lithium enolate to N-tosyl amine, which could lead to the synthesis of Enantiomerically pure beta-aryl-beta-amino acids. Dr. Ma has joined Professor M. P. Sibi's group in University of North Dakota as a postdoctoral fellow.

Ph.D thesis: Asymmetric Synthesis of beta–Amino Acids

Publications

(1) Stereoselective Nucleophilic Addition of Chiral Lithium Enolates to (N-Tosyl)imines: Enantioselective Synthesis of b-Aryl-b-amino Acid Derivatives
Zhihua Ma, Yonghua Zhao, Nan Jiang, Xianglin Jin, Jianbo Wang Tetrahedron Lett. 2002, 43, 3209-3212. Click Here

(2) Diastereoselective a-Alkylation of b-Amino Esters: Preparation of Novel
a-Substituted b-Amino Esters from a-Amino Acids
Zhihua Ma, Cong Liu, Yonghua Zhao, Wei Li, Jianbo Wang Chin Chem Lett. 2002, 13, 721-724. Click Here

(3) Recent Development in Asymmetric Synthesis of b-Amino Acids (A review in Chinese)
Zhihua Ma, Yonghua Zhao and Jianbo Wang, Chin. J. Org. Chem. 2002, 22, 807-816. Click Here

(4) Catalytic Asymmetric [2,3]-Sigmatropic Rearrangement of Sulfur Ylides generated from Copper(I) Carbenoids and Allyl Sulfides
Xiaomei Zhang, Zhaohui Qu, Zhihua Ma, Weifeng Shi, Xianglin Jin and Jianbo Wang, J. Org. Chem. 2002, 67, 5621-5625. Click Here

(5) Investigation on the Transition Metal and Acid Catalyzed Reaction of b-(N-Tosyl)amino Diazo Carbonyl Compounds
Nan Jiang, Zhihua Ma, Zhaohui Qu, Xiaoyu Xing, Linfeng Xie and Jianbo Wang J. Org Chem. 2003, 68, 893-900. Click Here

(6) Rh2(OAc)4-Mediated Diazo Decomposition of d-(N-Tosyl)amino-b-keto-a-diazo Carbonyl Compounds: An Novel Approach to Pyrrole Derivatives
Guisheng Deng, Nan Jiang, Zhihua Ma, Jianbo Wang, Synlett, 2002, 1913-1915. Click Here

(7) A Highly Stereoselective Addition of the Anion Derived from a-Diazoacetamide to Aromatic (N-Tosyl)imines
Yonghua Zhao, Zhihua Ma, Xiaomei Zhang, Yaping Zou, Xianglin Jin and Jianbo Wang
Angew. Chem. Int. Ed. 2004, 43, 5977-5980. Click here.