: Associate Professor
: Assistant Professor
: Postdoc Fellow, Massachusetts Institute of Technology
Ph.D. in Physical Chemistry, University of California, Berkeley
M.S. in Physical Chemistry, Peking University
B.S. in Chemistry, Peking University
Prof. Xin Sheng Zhao systematically revealed the dynamic mechanisms of nucleic acid intrachain collision of single stranded DNA, folding of hairpin DNA, spontaneous flipping of a mismatched base in double stranded DNA, DNA hybridization, and nucleic acid modification. He described the dynamic behavior of knot motion in the folding of protein TrmD. He found that kinetics play central role in the protection and quality control of biogenesis of outer membrane proteins. He developed the method of fluorescence correlation spectroscopy.
His primary research interests are the dynamic mechanisms of biomolecular reactions studied via single molecule detection. Special focus is on nucleic acid modification and protection and quality control of biogenesis of outer membrane proteins.
- Geng Li, Chenhui He, Peixuan Bu, Huimin Bi, Sichen Pan, Ronghua Sun, Xin Sheng Zhao*, ACS Chem. Biol. 2018, 13, 1082−1089. Single-Molecule Detection Reveals Different Roles of Skp and SurA as Chaperones.
- Lingyi Meng, Shanshan He, Xin Sheng Zhao*, J. Phys. Chem. B 2017, 121, 11262–11272. Determination of Equilibrium Constant and Relative Brightness in FRET-FCS by Including the Third-Order Correlations.
- Huimin Bi, Yandong Yin, Bailong Pan, Geng Li, Xin Sheng Zhao*, J. Phys. Chem. Lett. 2016, 7, 1865-1871. Scanning Single-Molecule Fluorescence Correlation Spectroscopy Enables Kinetics Study of DNA Hairpin Folding with a Time Window from Microseconds to Seconds.
- Peng Wang, Lijiang Yang, Yi Qin Gao*, Xin Sheng Zhao*, Nucleic Acids Res. 2015, 43, 7207-7216. Accurate Placement of Substrate RNA by Gar1 in H/ACA RNA-guided Pseudouridylation.
- Yandong Yin, Lijiang Yang, Guanqun Zheng, Chan Gu, Chengqi Yi, Chuan He, Yi Qin Gao*, and Xin Sheng Zhao*, PNAS 2014, 111, 8043-8048. Dynamics of spontaneous flipping of a mismatched base in DNA duplex.