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Peking University
中文 | Peking University
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Contact

Email: xinyuanfan@pku.edu.cn

Xinyuan Fan
Research Associate Professor of Chemical Biology

Biography

  • 2019-present, Research Associate Professor, Peking University

  • 2017-2019, Associate Professor, Nanjing Tech University

  • 2015-2017, Postdoctoral Fellow, Peking University

  • 2010-2014, PhD, Institute of Chemical Research of Catalonia, Tarragona, Spain

  • 2013-2013, Visiting scholar, University of Pennsylvania, Philadelphia, USA

  • 2003-2010, B.S & M.S., Lanzhou University, Lanzhou, China


Research Interests

Chemical biology, bioorthogonal photocatalysis, bioorthogonal chemistry, photocatalytic chemistry, proteomics


Selected Publications

Area 1: Bioorthogonal chemistry for protein regulation

  1. Zhu, Y.#, Ding, W.#,Fan, X.*,Lin, S.*, Chen, P.*, Genetically encoded bioorthogonal tryptophan decaging in living cells.Nat.Chem.2024,16(4), 533-542.

  2. Zhang, X.#; Huang, H.#; Liu, Y.; Wu, Z.; Wang, F.;Fan, X.*; Chen, P.*; Wang, J.*, Optical Control of Protein Functions via Genetically Encoded Photocaged Aspartic Acids.J. Am. Chem. Soc.2023, 145, 19218–19224.

  3. Ngai, W. S. C.#; Yang, S.#; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.;Fan, X.*;Chen, P.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis.J. Am. Chem. Soc.2022,144(12), 5411-5417.

  4. Wang J.#; Wang X.#;Fan, X.*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems.ACS Cent. Sci.20217(6), 929-943.

  5. Wang, X.#; Liu, Y.#;Fan, X.#;Wang, J.; Ngai, W. S. C.; Zhang, H.; Li, J.; Zhang, G.; Lin, J.*; Chen, P.* “Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications”,J. Am. Chem. Soc.2019,141(43), 17133.

Area 2: Photocatalytic chemistry for molecule construction

  1. Guo, F.#; Shan, S.#; Gong, X.#; Dai, C.; Quan, Z.*; Cheng, X.*;Fan, X.*, Deuteration Degree-Controllable Methylation via a Cascade Assembly Strategy using Methylamine-Water as Methyl Source.Chem. Eur. J.2023,e202301458.

  2. Zhu, J.#; Dai, C.#; Ma, M.; Yue, Y.;Fan, X.*, Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines.Org. Chem. Front.2021,8 (6): 1227-32.

  3. Lizandara-Pueyo, C.*;Fan, X.*; Ayats, C.; Pericàs, M. A., Calcium carbonate as heterogeneous support for recyclable organocatalysts.J. Catal.2021,393, 107-115.

  4. Wang, R.; Ma, M.; Gong, X.;Fan, X.*; Walsh, P. J.* “Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis”,Org. Lett.2019,21(1), 27-31.

  5. Fan, X.*; Gong, X.; Ma, M.; Wang, R.; Walsh, P. J.* “Visible Light-Promoted CO2Fixation with Imines to Synthesize Diaryl α-Amino Acids”,Nat. Commun.2018, 9(1), 4936.

  6. Wang, R.; Ma, M.; Gong, X.;Fan, X.*; Walsh, P. J.* “Visible Light-Mediated Umpolung Reactivity of Imines: Ketimine Reductions with Cy2NMe and Water”,Org. Lett.2018, 2433.

  7. Fan, X.;Walsh, P. J.* “Chelation-Controlled Additions to Chiral α- and β-Silyloxy, α-Halo, and β-Vinyl Carbonyl Compounds”,Acc. Chem. Res.2017,50, 2389.

Area 3: Bioorthogonal photocatalysis for spatiotemporal biology studies

  1. Liu, Z.#; Guo, F.#; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen, P.*;Fan, X.*, “Bioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples.”Nat. Commun.2024,15(1), 2712. (CAT-Stechnique)

  2. Zhang, Y.; Liu, S.; Guo, F.; Qin, S.; Zhou, N.;Fan, X.*; Chen, P.*, Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling.J. Am. Chem. Soc.2024, 146, DOI: 10.1021/jacs.4c02052. (CAT-Celltechnique)

  3. Guo, F.#; Qin, S.#; Liu, Z.#; Chen, P.*;Fan, X.*, Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling.Bioorg. Chem.2024,143, 107088.

  4. Liang, X.#; Qian, S.#; Lou, Z.; Hu, R.; Hou, Y.; Chen, P.*;Fan, X.*, Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice.Angew. Chem. Int. Ed.2023,e202310920. (CAT-NIRtechnique)

  5. Liu, Y.; Ge, Y.; Zeng, R.; Ngai William Shu, C.;Fan, X.*;Chen, P.*, Proximity Chemistry in Living Systems.CCS Chem.2023,5, 802-813.

  6. Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.;Fan, X.*;Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging.Chem2022, 8, 2179–2191. (CAT-Extechnique)

  7. Luo, H.#; Tang, W.#; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.;Fan, X.*;Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells.Angew. Chem. Int. Ed.2022,61(27), e202202008.

  8. Huang, Z.#; Liu, Z.#; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.;Fan, X.*;Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics.J. Am. Chem. Soc.2021,143(44), 18714-18720. (CAT-Proxtechnique)

For full list of publications, please see:‪Xinyuan Fan-‪Google Scholar‬‬

https://scholar.google.com/citations?

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