Biography

• Vice Director, Analytical Instrumentation Center, Peking University (2019-now)

• Professorate Senior Engineer, College of Chemistry and Molecular Engineering, Peking University (2015-now)

• Vice Dean, College of Chemistry and Molecular Engineering, Peking University (2015-2019)

• Senior Engineer, College of Chemistry and Molecular Engineering, Peking University (2008-2015)

• Postdoctoral Fellow, Department of Chemistry and Biochemistry, University of California, Santa Barbara, USA (2006-2008)

• Ph.D., College of Chemistry and Molecular Engineering, Peking University (2006)

• M.S., College of Chemistry and Molecular Engineering, Peking University (2001)

Research Interests

• Structure and interactions of nucleic acids based on mass spectrometry

• Native mass spectrometry combining ion mobility and ambient ion source

• Metabolomics and proteomics research based on sample pretreatment techniques

Facilities

Managing mass spectrometry lab in the Center, including 9 mass spectrometers such as FTICR-MS (Bruker solariX XR), Orbitrap Tribrid LC-MS (Thermo Fusion Lumos), Hybrid Quadrupole-Orbitrap GC-MS (Thermo Q Exactive GC), Quadrupole-TOF LC-MS (Waters Vion), MALDI-TOF (Sciex 5800), Triple Quadrupole LC-MS (Sciex 5500), etc., equipped with ESI, APCI, EI, MALDI, DART ion sources and FTICR, Orbitrap, TOF, quadrupole, ion mobility analyzers, which can support qualitative and quantitative analysis of small and large molecules, proteomics, metabolomics, structure analysis, in situ analysis, mass spectrometry imaging, native mass spectrometry and other applications.

Teaching

Characterization Techniques II (fall)

Awards

• 2015, Luye Eminent Young Scholar Fellowship (Peking University)

• 2007, Science & Technology Award of China Association for Instrumental Analysis (Second Prize, China)

Selected Publications

1. Zhou, Y.; He, L.; Tan, J.; Zhou, J.*; Liu, Y.* Rapid quantitative analysis of SVOCs in indoor surface film using Direct Analysis in Real Time mass spectrometry: A case study on phthalates. Atmos. Meas. Tech. 2024 17(21): 6415–6423.

2. Tian, H.; Lai, Z.; Zhang, M.; Liu, S.; Zhang, R.; Zhou, J.*; Li, Z.* Profiling of Amino Metabolites in Biological Samples without Protein Precipitation Using a Solid-Phase-Supported Phenyl Isothiocyanate-Based Chemoselective Probe. Anal. Chem. 2023, 95(25): 9539-9547.

3. Liu, S.; Lai, Z.; Zhang, M.; Tian, H.; Zhou, J.*; Li, Z.* Facile synthesis of amino-functionalized magnetic materials for efficient enrichment of anionic metabolites from biological samples. Anal. Chim. Acta 2023, 1250: 340977.

4. Xu, T.; Wang, J.; Tan, J.; Huang, T.; Han, G.; Li, Y.; Yu, H.; Zhou, J.*; Xu, M.* Gas chromatography-mass spectrometry pilot study to identify volatile organic compound biomarkers of childhood obesity with dyslipidemia in exhaled breath. J. Transl. Intern. Med. 2023, 11(1): 81-89.

5. Li, F.; Zhou, J.* G-quadruplexes from non-coding RNAs. J. Mol. Med. 2023, 101(6): 621-635.

6. Zhang, M.; Lai, Z.; Zhang, R.; Liu, S.; Tian, H.; Qiu, Y.; Li, D.; Zhou, J.*; Li, Z.* Polyurea‐Modified Magnetic Particles with Versatile Probes for Chemoselective Capture of Carbonyl Metabolites and Biomarker Discovery. Small 2023, 19(1): 2204734.

7. Zhang, L.; Zhou, J.*; Xu, M.; Yuan, G. Exploration of the hsa-miR-1587–protein interaction and the inhibition to CASK. Inter. J. Mol. Sci. 2021, 22(19): 10716.

8. Lai, Z.; Zhang, M.; Zhou, J.; Chen, T.; Li, D.; Shen, X.; Liu, J.; Zhou, J.*; Li, Z.*, Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N -glycopeptides. Analyst 2021, 146(13): 4261-4267.

9. Xi, M.; Li, Y.*; Zhou, J.* Exploration of the formation and structure characteristics of a miR-92a promoter G-quadruplex by ESI-MS and CD. Talanta 2020, 211: 120708.

10. Li, F.; Tan, W.; Chen, H.; Zhou, J.*; Xu, M.; Yuan, G.*Up- and downregulation of mature miR-1587 function by modulating its G-quadruplex structure and using small molecules. Inter. J. Biol. Macromol. 2019, 121: 127-134.