Biography

• Engineer, College of Chemistry and Molecular Engineering, Peking University (2024-now)

• Postdoctoral Fellow, College of Chemistry and Molecular Engineering, Peking University (2022-2024)

• Ph.D., College of Chemistry and Molecular Engineering,Peking University (2017-2022)

• B.S., College of Chemistry,Nankai University (2013-2017)

Research Interests

• Organic and biological mass spectrometry

• Novel MS ion source interfaces

• Metabolomics and proteomicsstrategies

• Activity based chemical labeling probes

Facilities

• Fourier Transform Ion Cyclotron Resonance Mass Spectrometer, Solarix XR, Bruker

Resolution 10000000,error< 1ppm,mass range 20-10000 Da

Organic molecule structure identification, pharmaceutical development, metabolite analysis, and identification of environmental and petroleum organic matter

• Hybrid Quadrupole-Orbitrap GC-MS/MS System, Q Exactive GC, Thermo

Resolution 120000,error< 1ppm,Intensity~ppt level, IDL<6 fg OFN

Low polarity small molecule detection, drug analysis, metabolite analysis, metabolic flux analysis, and other GC-MS analyses

Awards

• 2023: China Postdoctoral Science Foundation

• 2023: BMS Junior Fellow, Beijing National Laboratory for Molecular Sciences

• 2022: Peking University Boya Postdoctoral Fellowship

Selected Publications

1. Ying Liu, Yu-Nan Chen, Jie Cheng, Jin-Xin Yan, Chen-Yu Xue, Hui-Yu Pan, Xu-Yang Shen, Jiang Zhou, Peng Jiang*, Ying-Lin Zhou*, Xin-Xiang Zhang*, Ultrasensitive HPLC-MS quantification of S-(2-succino) cysteine based on ethanol/acetyl chloride derivatization in fumarate accumulation cells, Analytical Chemistry, 2023, 95(3): 1817-1822.

2.  Jie Cheng#, Jin-Xin Yan#, Ying Liu#, Jiang-Zhou Shi#, Hao-Yu Wang, Han-Yang Zhou, Ying-Lin Zhou, Tong-Cun Zhang, Li-Na Zhao, Xian-Bin Meng, Hai-Peng Gong, Xin-Xiang Zhang*, Hai-Chuan Zhu*, Peng Jiang*, Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment, Cell Metabolism, 2023, 35(6): 961-978.

3. Jie Cheng#, Ying Liu#, Jin-Xin Yan#, Li-Na Zhao, Ying-Lin Zhou, Xu-Yang Shen, Yu-Nan Chen, Yi-Ning Chen, Xian-Bin Meng, Xin-Xiang Zhang*, Peng Jiang*, Fumarate suppresses B-cell activation and function through direct inactivation of LYN, Nature Chemical Biology, 2022, 18(9): 954-962.

4. Ying Liu, Xiao-Hui Zhang, Wei-Dong Mi, Ying-Lin Zhou*, Chang-Sheng Zhang*, Xin-Xiang Zhang*, Rapid determination and continuous monitoring of propofol in microliter whole blood sample during anesthesia by paper spray ionization-mass spectrometry, Analytical and Bioanalytical Chemistry, 2021, 413(1): 279-287.

5. Ying Liu#, Xiao-Hui Zhang#, Yue Yu, Hong-Xu Chen*, Ying-Lin Zhou*, Xin-Xiang Zhang*, Snake venom characteristic peptides: novel fingerprints for species identification by sheathless capillary electrophoresis-electrospray ionization-mass spectrometry, Analyst, 2020, 145(14): 5027-5031.