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Contact

Email: fgai@pku.edu.cn
Tel: +86-10-62752665
Office: A626 Chemistry Building
Research Group: www.chem.pku.edu.cn/gailab

Feng Gai
​Professor of Physical Chemistry

Biography

  • Chair Professor, College of Chemistry and Molecular Engineering, Peking University (December 2021 – present)

  • Edmund J. and Louise W. Kahn Term Professor, Department of Chemistry, University of Pennsylvania (July 2014 – October 2021)

  • Assistant, Associate and Full Professor, Department of Chemistry, University of Pennsylvania (August 1999 – October 2021)

  • Postdoctoral Fellow in Biophysics, Los Alamos National Lab(1997-1999)

  • Postdoctoral Fellow in Biophysics, Harvard University(1994-1997)

  • Ph.D. in Physical Chemistry, Iowa State University (1994)

  • Lecturer, Department of Chemistry, Tsinghua University (August 1986 – June 1989)

  • M.S. in Physical Chemistry, Peking University(1986)

  • B.S. in Chemistry, Peking University(1983)


Research Interests

We are interested in applying linear and nonlinear spectroscopic techniques based on molecular vibrations and electronic transitions to study the folding mechanisms, structure, conformational dynamics, and functions of biomacromolecules at the molecular level. Our current research efforts include, but are not limited to:

  • Development of spectroscopic probes based on unnatural amino acids;

  • Creation of molecular rulers based on energy or electron transfer;

  • How environmental conditions affect the folding, aggregation, reactions, and kinetics of biomolecules;

  • Modulation of biochemical reactions using unnatural amino acids;

  • Development of multi-dimensional vibrational spectroscopy techniques based on scattering;

  • Development of imaging techniques based on chemical reactions.


Teaching

  • Chemical Kinetics and Mechanism


Awards and Services

  • Senior Editor, The Journal of Physical Chemistry (2024 – present)

  • Bayer Endowed Chair, Bayer-PKU Center for Translational Research (2021)

  • Chair Professor of Peking University (2021)

  • Editorial Advisory Board, The Journal of Physical Chemistry (2015 – 2018)

  • Molecular Science Frontier Lecture Professorship, Institute of Chemistry, CAS (2016)

  • American Chemical Society Philadelphia Section Award (2014)

  • Alumni Excellence Award, Department of Chemistry, Iowa State University (2014)

  • Edmund J. and Louise W. Kahn Term Professor of Chemistry, UPenn (2014)

  • Fellow of the American Association for the Advancement of Science (2012)

  • Editorial Board, Biophysical Journal (July 2006 – June 2012)

  • Member, NIH MSFB Study Section (July 2007 – June 2011)

  • Fellow of the American Physical Society (2011)

  • National Science Foundation CAREER Award (2001)

  • Research Innovation Award, Research Corporation (2000)

  • Director’s Postdoctoral Fellowship, Los Alamos National Lab (1997)

  • Zaffarano Prize for Graduate Student Research, Iowa State University (1994)

  • Henry Gilman Fellowship, Department of Chemistry, Iowa State University (1993)

  • Phillips Fellowship, Department of Chemistry, Iowa State University (1992)


Selected Publications

Listed below are representative perspective and review articles, other publications can be found via Google Scholar (User Name: Feng Gai)

  1. Unnatural amino acids for biological spectroscopy and microscopy. R. R. Feng, M. Wang, W. K. Zhang, and F. Gai. Chem. Rev. 2024 124, 10, 6501–6542.

  2. Triple-bond vibrations: Emerging applications in energy and biological sciences. L. Zhou, R. R. Feng, W. K. Zhang, and F. Gai. J. Phys. Chem. Lett. 2024 15, 1, 187–200.

  3. Tryptophan as a template for development of visible fluorescent amino acids. A. Acharyya, W. K. Zhang, and F. Gai. J. Phys. Chem. B 2021 125, 5458–5465.

  4. Infrared and fluorescence assessment of protein dynamics: From folding to function. B. Ding, M. R. Hilaire, and F. Gai. J. Phys. Chem. B 2016 120, 5103−5113.

  5. Biomolecular crowding arising from small molecules, molecular constraints, surface packing, and nano-confinement.  M. R. Hilaire, R. M. Abaskharon, and F. Gai.  J. Phys. Chem. Lett. 2015 6, 2546−2553.

  6. Site-specific infrared probes of proteins.  J. Q. Ma, I. M. Pazos, W. K. Zhang, R. M. Culik, and F. Gai.  Annu. Rev. Phys. Chem. 2015 66, 357–77.

  7. Spectroscopic studies of protein folding:  Linear and nonlinear methods.  A. L. Serrano, M. M. Waegele, and F. Gai. Prot. Sci. 2012 21, 157-170.

  8. Site-specific spectroscopic reporters of the local electric field, hydration, structure, and dynamics of biomolecules.  M. M. Waegele, R. M. Culik, and F. Gai. J. Phys. Chem. Lett. 2011 2, 2598–2609.

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