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Contact

Email: Zbliu@pku.edu.cn
Office: 519 Jiwu Building
Research Group: https://www.chem.pku.edu.cn/zliu/

Zhibo Liu
​Professor of Applied Chemistry

Biography

  • Professor, College of Chemistry and Molecular Engineering, Peking University (2023-now)

  • Tenure-tracked Assistant Professor, College of Chemistry and Molecular Engineering, Peking University (2016-2022)

  • Tenured Associate Professor, College of Chemistry and Molecular Engineering, Peking University (2022-2023)

  • Postdoctoral Research Fellow, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health(2014-2016)

  • Ph.D. in Radiopharmaceutical Chemistry, University of British Columbia (2014)

  • B.S. in Chemistry, Nanjing University (2010)


Research Interests

My research interests have centered on developing radiopharmaceuticals and radiochemical tools for probing and perturbing biological processes in living systems, with a particular focus on cancer. This mainly follows three lines of efforts: (1) Cyclotron-based production of medical radionuclides, development and translational study of new radiopharmaceuticals for cancer theranostics (2) Novel in vivo chemistry that enables PET imaging probes for localized protein activation (e.g.gasdermin for pyroptosis) and controlled drug release; (3) Radiotherapy-induced controlled drug release in tumors.


Teaching

  • GeneralChemistryB

  • IntroductiontoPharmaceutical Chemistry


Awards

  • 2024.08, Xplorer Prize, New Cornerstone Science Foundation

  • 2024.04, Bayer Investigator Award, Bayer Healthcare Co. Ltd.

  • 2023.10, Graduate Teaching Excellence Award, Peking University

  • 2022.09, Distinguished Young Scholar Fund, National Natural Science Foundation

  • 2021.04, Young Scholar Award, Chinese Chemistry Society

  • 2020.09,Teaching Excellence Award, Peking University

  • 2019.12, WuXi Eminent Young Scholar Award, WuXi-AppTech

  • 2018.11, Fairchild Award, International Society of Neutron Capture Therapy

  • 2016.06, Distinguished Scientist Award, NIH-CSSA Committee

  • 2015.06, Michael J. Welch Postdoctoral Grant, Society of Nuclear Medicine and Molecular Imaging

  • 2015.06, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging

  • 2015.04, Alavi-MandellAward, Society of Nuclear Medicine and Molecular Imaging

  • 2014.08, Edward Piers Memorial Award, Edward Piers Foundation

  • 2013.06, Young Scientist Award, 37th CASNM

  • 2013.02, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation

  • 2010.03, Tsang Hin-chi Academic Award, Tsang Hin-chi Foundation

  • 2006.01, Silver Medal, 21th Chinese Chemistry Olympiad


Selected Publications

  1. Xi-Yang Cui#, Zhu Li#, Ziren Kong#, Yu Liu, Hao Meng, Zihao Wen, Changlun Wang, Junyi Chen, Mengxin Xu, Yiyan Li, Jingyue Gao, Wenjia Zhu, Zhixin Hao, Li Huo, Shaoyan Liu, Zhi Yang, Zhibo Liu*. Covalent Targeted Radioligands Potentiate Radionuclide Therapy. Nature. 2024, 630: 206–213.

  2. Qinyang Wang#, Yupeng Wang#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426

  3. Qunfeng Fu#, Zhi Gu#, Siyong Shen#, Yifei Bai, Xianglin Wang, Mengxin Xu, Pengwei Sun, Junyi Chen, Dongxuan Li, Zhibo Liu*. Radiotherapy Activates Picolinium Prodrugs in Tumors. Nat Chem.  2024, 16(8): 1348–1356.

  4. Qunfeng Fu, Shuren Zhang, Siyong Shen, Zhi Gu, Junyi Chen,  Dongfan Song, Pengwei Sun, Chunhong Wang, Zhibin Guo, Yunlong Xiao, Yi Qin Gao, Zijian Guo*, Zhibo Liu*. Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours.  Nat Biomed Eng.  2024, 8: 1425–1435.

  5. Ziren Kong#,Zhu Li#, XiYang Cui#, Wang Jian, Mengxin Xu, Yang Liu, Junyi Chen, Song Ni, Xiaowei Fan, Jiazhao Huang, Yansong Lin, Xinfeng Lin, Tianyu Men, Changming An, Nan Li, Chen Liu, Yi-Ming Zhu, Zhi Yang*, Zhibo Liu*, Shaoyan Liu*. CTR-FAPI PET enables precision management of medullary thyroid carcinoma. Cancer Discov. 2025, 15 (2): 316–328. 

  6. Junyi Chen, Mengxin Xu, Zhu Li, Ziren Kong,  Jie Cai, Chunhong Wang, Bo-Shuai Mu, Xi-Yang Cui, Zizhu Zhang,  Tong Liu, Zhibo Liu*. A Bis-Boron Amino Acid for Positron Emission Tomography and Boron Neutron Capture Therapy. Angew Chem Int Ed. 2025, 64(1): e202413249. 

  7. Mengqi Chen#, Chunhong Wang#, Xuanyu Wang, Zhiyu Tu, Zexuan Ding, Zhibo Liu*. An “AND” Logic-Gated Prodrug Micelle Locally Stimulates Antitumor Immunity. Adv Mater. 2024,  36(6): 2307818.

  8.  Bo-Shuai Mu#, Yugang Zhang#, Mi Peng#, Zhiyu Tu, Zhenbo Guo, Siyong Shen, Yang Xu, Weiqiu Liang, Xianglin Wang, Meng Wang, Ding Ma*, Zhibo Liu*. Radiocatalytic Synthesis of Acetic Acid from CH4 and CO2. Angew Chem Int Ed. 2024, 63(44): e202407443.

  9. Bo-Shuai Mu#, Yang Xu#, Zhiyu Tu, Weiqiu Liang, Jiahao Li, Xianglin Wang, Siyong Shen, Junyi Chen, Zhibo Liu*. Radiocatalytic ammonia synthesis from nitrogen and water. National Science Review. 2024, 11(11): nwae302.

  10. Changlun Wang, Mengxin Xu, Zihang Zhang, Senhai Zeng, Siyong Shen, Zexuan Ding, Junyi Chen, Xi-Yang Cui, Zhibo Liu *. Locally unlocks prodrugs by radiopharmaceutical in tumor for cancer therapy. Science Bulletin. 2024, 69(17): 2745-2755.

  11. Zhibin Guo, Xuanyu Wang, Yi Han, Siyong Shen, Peng Tian, Yuchen Hu, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Targeted Radionuclide Therapy Activates Prodrugs for Treating Metastasis. ACS Cent Sci. 2024, 10(12):2321-2330.

  12. Zhu Li#, Junyi Chen#, Ziren Kong, Yixin Shi, Mengxin Xu, Bo-Shuai Mu, Nan Li, Wenbin Ma, Zhi Yang, Yu Wang*, Zhibo Liu*. A bis-boron boramino acid PET tracer for brain tumor diagnosis. Eur J Nucl Med Mol Imag. 2024, 51(6):1703-1712.

  13. Qunfeng Fu#, Siyong Shen#, Pengwei Sun, Zhi Gu, Yifei Bai, Xianglin Wang, Zhibo Liu*. Bioorthogonal chemistry for prodrug activation in vivo. Chem Soc Rev. 2023, 52: 7737-7772.

  14. Dongban Duan#, Yi Han#, Zhiyu Tu#, Haoxuan Guo, Zizhu Zhang, Yaxin Shi, Jiyuan Li, Qi Sun, Junyi Chen, Zhu Li, Tong Liu, Daqing Cui, Zhibo Liu*. Gadolinium Neutron Capture Reaction-Induced Nucleodynamic Therapy Potentiates Antitumor Immunity. CCS Chemistry. 2023, 5(11): 2589-2602.

  15. Qiang Wei, Yuhxuan Lee, Weiqiu Liang, Xiaolei Chen, Bo-Shuai Mu, Xi-Yang Cui, Wangsuo Wu, Shuming Bai, Zhibo Liu*. Photocatalytic Direct Borylation of Carboxylic Acids. Nat Commun, 2022, 13, 7112.

  16. Zhibin Guo#, Hanyu Hong#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, 61, e202205014.

  17. Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8,837.

  18. Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*, Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors, J Am Chem Soc, 2022, 144, 9458.

  19. Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat Commun, 2022, 13, 2143.

  20. Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996.

  21. Mengxin Xu#, Pu Zhang#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2022, 63, 952.

  22. Zhu Li#, Ziren Kong#, Junyi Chen#, Jiyuan Li, Nan Li, Zhi Yang*, Yu Wang*, Zhibo Liu*, 18F-Boramino Acid PET/CT in Healthy Volunteers and Glioma Patients, Eur. J. Nucl. Med. Mol. Imaging, 2021, 48, 3113–3121.

  23. Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, Cationic Micelle as An In Vivo Catalyst for Tumour-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 133, 19903–19911.

  24. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255.

  25. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552.

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