Biography

• 2022-now: Executive Editor, ACS Chemical Biology, American Chemical Society

• 2020-now: Director, Synthetic and Functional Biomolecules Center, Peking University

• 2021-now: Director, Division of Chemical Biology, Chinese Chemical Society

• 2015-now: Chairman, Department of Chemical Biology, Peking University

• 2014-now: Professor, Department of Chemical Biology, Peking University

• 2011-2015: Investigator, Peking-Tsinghua Center for Life Sciences

• 2009-2014: Investigator, Department of Chemical Biology, College of Chemistry, Peking University

• 2007-2009: Postdoctoral Fellow, the Scripps Research Institute, Advisor: Prof. Peter G. Schultz

• 2002-2007: Ph.D in Chemistry (2007), University of Chicago, Chicago, USA

• 1998-2002: B.S. in Chemistry, Peking University, Beijing, China

• 1999-2002: B.S. Double degree in Economics, Peking University, Beijing, China

Research Interests

Our group is interested in developing and applying new chemistry tools to investigate protein-based interactions and activities in living systems. We have been leading the development of bioorthogonal cleavage reactions, which has enabled the in situ gain-of-function study of proteins as well as other biomolecules in living cells and animals. This has opened an exciting new avenue in bioorthogonal chemistry with broad utilities in life sciences and medicine. We have also developed a series of genetically encoded protein labeling, crosslinking and proximity-tagging tools for monitoring biomolecule interactions as well as cell communications during various physiological and pathological processes. Most recently, we started to leverage this exciting toolkit to better understand the mode-of-action of immunotherapy.

Teaching

• Introduction to Chemical Biology

• Chemical Biology

Awards

• 2023: The Science and Technology Innovation Award, Ho Leung Ho Lee Foundation

• 2023: New Cornerstone Investigator

• 2020: National Award for Natural Sciences of China

• 2010: Fellow, Chinese Chemical Society

• 2019: Natural Science Award, Ministry of Education, China

• 2019: XPLORER Prize

• 2019: C.C. Tan Life Science Award

• 2017: Society of Biological Inorganic Chemistry (SBIC) Early Career Award

• 2016: Tan Kah Kee Young Scientist Award

• 2016: Young Scientist Award, Ministry of Education (China)

• 2016: OKeanos-CAPA Young Investigator Award at the Chemistry and Biology Interface

• 2015: China Association for Instrumental Analysis (CAIA) Award

• 2015: The Chemical Society of Japan Distinguished Lectureship Award

• 2015: Young Science and Technology Innovation Talents

• 2014: Roche Chinese Young Investigator Award

• 2014: (RSC) Chem Soc Rev Emerging Investigator Lectureship

• 2014: CAPA Biomatik Distinguished Faculty Award

Selected Publications

1. Li K, Xie X, Gao R,et al,Chen P. “Spatial-temporal protein interactome profiling via condensation enhanced photo-crosslinking”,Nat. Chem.(2024),accepted.

2. Zhu Y, Ding W,Fan X, Lin S,Chen P,“Genetically encoded bioorthogonal tryptophan decaging in living cells”,Nat. Chem.(2024),16, 533-42.

3. Weng Y, Chen W, Kong Q,et al, Tian R,Chen P.“DeKinomics pulse-chases kinase functions in living cells”,Nat. Chem. Biol.(2024),20,615-23.

4. Qin F, Li B, Wang H, Ma S,et al, Ji X,Chen P.“Linking chromatin acylation mark-defined proteome and genome in living cells”,Cell, (2023),186, 1066-85.

5. Huang Z, Liu Z, Xie X, Zeng R, Chen Z, Kong L, Fan X,Chen P. “Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics”,J. Am. Chem. Soc.(2021),143, 18714-20.

6. Liu Y, Zeng R, Zou P,Chen P. “Spatiotemporally resolved subcellular phosphoproteomics”,Proc. Natl. Acad. Sci. USA.(2021), 118, e2025299118.

7. Wang J, Liu Y, Liu YJ, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C,Chen P. “Time-resolved protein activation by proximal decaging in living systems”,Nature,(2019),569, 509-13.

8. Li J,Chen P. “Development and application of bond cleavage reactions in bioorthogonal chemistry”,Nat. Chem. Biol.(2016),12, 129-37.

9. Li J, Jia S,Chen P. “Diels-Alder reaction-triggered bioorthogonal protein activation in living cells”,Nat. Chem. Biol.(2014),10, 1003-5.

10. Li J, Yu J,et al,Chen P. “Palladium-triggered deprotection chemistry for protein activation in living cells”,Nat. Chem.(2014),6, 352-61.