Professional Experiences：

2022 – BoYa Distinguished Professor, College of Chemistry and Molecular Engineering, Peking University
2020 – 2022 Associate Editor of the ACS journal Biomacromolecules
2020 – 2022 Associate Professor with tenure, College of Chemistry and Molecular Engineering, Peking University
2014 – 2020 Assistant Professor, College of Chemistry and Molecular Engineering, Peking University

Education and Training：

2011 – 2014 Postdoctoral fellow, The Scripps Research Institute
Mentor: Prof. Peter G. Schultz
2006 – 2011 Ph.D., Department of Materials Science and Engineering, University of Illinois at Urbana Champaign
Advisor: Prof. Jianjun Cheng
2002 – 2006 B.S., College of Chemistry and Molecular Engineering, Peking University

Research Areas:

Inspired by the structural precision and functional delicacy of natural biomacromolecules such as proteins and DNA, the research of our lab aims to bridge the gap between synthetic polymers with their natural counterparts. With this goal, we focus on the development of sustainable and recyclable polymers from renewable sources, catalysts for the controlled synthesis of functional polypeptides, and novel protein-polymer biohybrid materials for various biological and biomedical applications. To carry out the research, we harness the power of an array of technologies including organic/polymeric synthesis, molecular design, advanced biotechnologies, artificial intelligence, automation, and collaborate with expertise in biophysics, bioinformatics, clinical medicine, theoretical simulations, and modeling.

Selected Awards and Honors：

• Chinese Chemical Society- The Royal Society of Chemistry Prize for Young Scientists (2023)

• WuXi AppTech Scholar Award for Biological Chemistry Research (2022)

• Excellence in Teaching, Peking University (2022)

• Distinguished Young Investigator, NSFC (2021)

• ACS PMSE Young Investigator (2020)

• International Leading Young Scientist of The Society of Polymer Science, Japan (2020)

• Young Scholar Award of CCS Polymer Division (2019)

• Chinese Chemical Society (CCS) Prize for Young Scientists (2017)

• Excellent Young Investigator, NSFC (2017)

• ACS AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry (2013)

• IUPAC Prize for Young Chemists, Honorable Mention Award (2012)

• Damon-Runyon Cancer Foundation Postdoctoral Fellowship Award (2011-2014)

Selected Publications in the past 5 years:

1. Haisen Zhou,† Guangqi Wu*,†, Zuo Zhang,† Zhen Zhu, Tanfeng Zhao, Qiankang Zhou, Haolin Chen, Zhenzhong Zhao, Yuanhao Dai, Xiaodong Jing, Wei Ji, Xuehai Yan, Lijiang Yang, Yiqin Gao, Huan Wang*, Hua Lu* “Data-driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies”, J. Am. Chem. Soc. 2025, 147, 21077–21088. (†equal contribution)

2. Ruichi Zhao,† Yangming Zhang,† Banlai Ruan, Hairuo Zhang, Niannian Lv, Jiayi Li, Yuhe R. Yang*, Xiaozhou Luo*, Hua Lu* “Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations”, Angew. Chem. Int. Ed. 2025, 64, e202425559. (†equal contribution)

3. Shuo Wang, Zi-You Tian, and Hua Lu*, “Recyclable Polythioesters and Poly(thioester-co-peptoid)svia Ring-Opening Cascade Polymerization of Amino Acid N-Carboxyanhydrides”, Angew. Chem. Int. Ed. 2024, 146, e202411630. 

4. Shuo Wang, Ming-Yuan Lu, Si-Kang Wan, Chun-Yan Lyu, Zi-You Tian, Kai Liu, and Hua Lu*, “Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and Mechanistic Insights”, J. Am. Chem. Soc. 2024, 146, 5678–5692. 

5. Jianhua Lu, Yuanhao Dai, Yahui He, Ting Zhang, Jing Zhang, Xiangmei Chen, Changtao Jiang, and Hua Lu*, “Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates”, J. Am. Chem. Soc. 2024, 146, 3974–3983. 

6. Guangqi Wu, Haisen Zhou, Jun Zhang, Zi-You Tian, Xingyi Liu, Shuo Wang, Connor W. Coley, and Hua Lu*, “A High-Throughput Platform for Efficient Exploration of Functional Polypeptide Chemical Space”, Nat. Synth. 2023, 2, 515-526. 

7. Y. Hu, Z.-Y. Tian, W. Xiong, D. Wang, R. Zhao, Y.Xie, Y.-Q.Song, J. Zhu, and H. Lu*; “Water-Assisted and Protein-Initiated Fast and Controlled Ring-Opening Polymerization of Proline N-Carboxyanhydride”, Natl. Sci. Rev. 2022, 9, nwac033.

8. Jianhua Lu, Zhun Xu, Hailin Fu, Yao Lin, Huan Wang, and Hua Lu*, “Room-Temperature Grafting from Synthesis of Protein–Polydisulfide Conjugates via Aggregation-Induced Polymerization”, J. Am. Chem. Soc. 2022, 144, 15709-15717. 

9. C. Dong†; G. Wu†; C. Chen; X. Li; R. Yuan; L. Xu; J. Zhang; H. Guo; J. Zhang; H. Lu*, and F. Wang*; “Site-specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e2021152. (†equal contribution) (Hot Paper). 

10. Z.-Y. Tian; Z. Zhang; S. Wang; and H. Lu*, “A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-Carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides”, Nat. Commun. 2021, 12, 5810.

11. W. Xiong; W. Chang; D. Shi; L. Yang; Z.-Y. Tian; H. Wang; Z. Zhang; X. Zhou; E.-Q. Chen,* and H. Lu*, “Geminal Dimethyl Substitution Enables Controlled Polymerization of Penicillamine-Derived β-Thiolactones and Reversed Depolymerization”, Chem 2020, 6, 1831-1843. (Highlighted by Chem)

12. J. Lu; H. Wang; Z.-Y. Tian; Y. Hou; and H. Lu*, “Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein-Polydisulfide Conjugates”, J. Am. Chem. Soc. 2020, 142, 1217-1221. (Selected as JACS Early Career Investigators Virtual Issue)