Biography
Principle Investigator, College of Chemistry and Molecular Engineering, Peking University (2022-now)
Professor, College of Chemistry and Molecular Engineering, Peking University (2021-now)
Associate Professor, College of Chemistry and Molecular Engineering, Peking University (2010-2021)
Lecturer, College of Chemistry and Molecular Engineering, Peking University (2008-2010)
Postdoctoral Fellow, Center for Research in Neurodegenerative Diseases, University of Toronto (2005-2008)
Ph. D, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (1998-2004)
Exchanging Ph. D student, University of Konstanz（2002-2004）
B. S., Jilin University (1994-1998)
Research Interests
High throughput and sensitive qualitative and quantitative analysis of markers in complex biological systems is the fundamental of analytical chemistry and the key to early diagnosis of major diseases, disclosure of molecular mechanism and precision clinical treatment. Yu Bai’s research focuses on the accurate measurement of markers in complex biological systems based on mass spectrometry, including the novel ambient mass spectrometry platform, metabolomic and proteomic methods and clinical applications, and multi-omics single-cell mass spectrometry analysis.
Teaching
Quantitative Analytical Chemistry Laboratory
Chromatography-Mass Spectrometry Analysis
Advanced Chromatography Analysis
Awards
Dr. Yu Bai has published more than 120 peer-reviewed papers, including J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., Chem. Sci.and Anal. Chem. etc., h-index 38. She is now on the Early Career Board of Analytical Chemistry, and the editorial board of the Journal of American Mass Spectrometry Society, Analytical and Bioanalytical Chemistry, Mass Spectrometry Letter, Separation Science Plus, Chemistry Journal of Chinese Universities, Journal of Chinese Chromatography, Journal of Chinese Mass Spectrometry Society etc.
2023 Science and Technology Award of China Association for Instrumental Analysis (China) (First-class, first awardee)
2022, BoYa Distinguished Professor (Peking University)
2021, National Science Fund for Distinguished Young Scholars
2020, The Excellent Doctoral Thesis Instructor of Peking University (Peking University)
2019, The Excellent Doctoral Thesis Instructor of Peking University (Peking University)
2015, Science and Technology Award of China Association for Instrumental Analysis (China) (First-class, first awardee)
2014, Lvye Bio-Pharmaceutical Outstanding Young Scholar (Peking University)
2013, NSFC Excellent Young Scientist Fund (China)
2007, Canadian Institutes of Health Research (CIHR) Training Fellowship (Canada)
Selected Publications
Shaojie Qin, Yi Zhang, Mingying Shi, Daiyu Miao, Jiansen Lu, Lu Wen and Yu Bai*. In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level. Nat. Commun. 2024, 15, 4387.
Shaojie Qin, Daiyu Miao, Xue Zhang, Yi Zhang, Yu Bai*, Methods developments of mass spectrometry based single cell metabolomics, TrAC Trends in Anal. Chem., 2023, 117086.
Mingxia Liu, Daiyu Miao, Shaojie Qin, Huwei Liu, Yu Bai*, Mass Tag-based Mass Spectrometric Immunoassay and its Bioanalysis Applications, TrAC Trends in Anal. Chem., 2022, 157, 116745.
Shuting Xu, Mingxia Liu, Yu Bai* and Huwei Liu, Multi-Dimensional Organic Mass Cytometry: Simultaneous Analysis of Proteins and Metabolites on Single Cells. Angew Chem Int. Ed., 2021, 60, 1806.
Shuting Xu, Mingxia Liu, Jie Feng, Guangtao Yan, Yu Bai* and Huwei Liu, One-step Hexaplex Immunoassays by On-line Paper Substrate-based Electrospray Ionization Mass Spectrometry for Combined Cancer Biomarker Screening, Chem. Sci., 2021, 12, 4916.
Wanpeng Ai, Qirong Yang, Yunpeng Gao, Xiaoyun Liu, Huwei Liu and Yu Bai*, In Situ Laser Scattering Electrospray Ionization Mass Spectrometry and Its Application in the Mechanism Study of Photoinduced Direct C-H Arylation of Heteroarenes, Anal. Chem., 2020, 92, 17, 11967.
Shuting Xu, Wen Ma, Yu Bai* and Huwei Liu, Ultrasensitive Ambient Mass Spectrometry Immunoassays: Multiplexed Detection of Proteins in Serum and on Cell Surfaces, J. Am. Chem. Soc., 2019, 141, 72.
Wen Ma, Shuting Xu, Honggang Nie, Bingyang Hu, Yu Bai* and Huwei Liu, Bifunctional Cleavable Probe for In-situ Multiplexed Glycan Detection and Imaging Using Mass Spectrometry, Chem. Sci., 2019, 10, 2320.