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Peking University
中文 | Peking University
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Contact

Email: wenbin@pku.edu.cn
Tel: +86-10-62766876
Office: RM 2104W, Ziyuan West Buildin
Research Group: Laboratory for Macromolecular Design and Evolution (https://www.chem.pku.edu.cn/zhangwb/)

Wenbin Zhang
​Professor of Polymer Chemistry

Biography

  • Associate Director, Center for Soft Matter Science and Engineering, Peking University（2022-now）

  • Editor for the journal Bioorganic Chemistry(2021-now)

  • FullProfessor, College of Chemistry and Molecular Engineering, Peking University (2020-now)

  • Tenured AssociateProfessor, College of Chemistry and Molecular Engineering, Peking University (2019-2020)

  • Assistant Professor, College of Chemistry and Molecular Engineering, Peking University (2013-2019)

  • Postdoctoral Scholar, California Institute of Technology (2011-2013)

  • Postdoctoral Research Associate, The University of Akron (2010-2011)

  • Ph.D.in Polymer Science, The University of Akron (2010)

  • B.S. in Organic Chemistry, Peking University (2004)


Research Interests

To develop unique “precision macromolecules" by integrating the design principles and building blocks of both synthetic and biological polymers for applications in materials science and chemical biology.


Teaching

BiomacromolecularEngineering


Awards

  • Lectureship Award for Innovative Young Supramolecular Chemists, Chinese Chemical Society (2023)

  • Bayer Investigator Award (2021)

  • The Asian Universities Alliance (AUA) Scholars Award (2020)

  • Distinguished Young Scholars Award, NSFC (2019)

  • Third Prize & The Most Popular Teacher Award selected by the students in the 11th Young Scholar Teaching Basic Skills Competition of Beijing (2018)

  • First Prize & The Best Lesson Plan Award in the 18th Young Scholar Teaching Basic Skills Competition, Peking University (2018)

  • Asian International Symposium Distinguished Lectureship Award, Chemical Society of Japan (2017)

  • Excellence in Graduate Polymer Research, American Chemical Society (2010)

  • Frank N. Kelly Fellowship in Recognition of Excellent Research and Course Work Performance, the University of Akron (2009)

  • Ticona Award in Recognition of Best Research Presentation Performance, the University of Akron (2009)

  • Lubrizol Fellowship in Recognition of Excellent Research and Course Work Performance, the University of Akron (2008)

  • Ticona Award in Recognition of Best Formal Seminar Performance, the University of Akron (2008)

  • Ronald K. Eby Award in Recognition of Academic Excellence, the University of Akron (2007)

  • First Prize in National Chemistry Olympiad, Chinese Chemical Society (2000)


Selected Publications

  1. Qu, Z.; Xu, L.; Jiang, F.; Liu, Y.; Zhang, W.-B.*Folds from Fold: Exploring Topological Isoforms of a Single Domain Protein. Proc. Natl. Acad. Sci. USA 2024, 121, e2407355121.

  2. Liu, Y.; Tian, X.; Zhang, F.; Zhang, W.-B.* Probing the Topological Effects on Stability Enhancement and Therapeutic Performance of Protein Bioconjugates: Tadpole, Macrocycle versus Figure-of-Eight. Adv. Healthcare Mater. 2024, 2400466.

  3. Zhang, F.; Liu, Y.;Da, X.-D.; Zhang, W.-B.* Toward Selective Synthesis of Protein Olympiadanes via Orthogonal Active Templates in One Step.CCS Chem. 2024,6,1047-1059.

  4. Xu, L.; Deng, P.; Gao, H.;*Zhang, W.-B.* Systematic Discovery and Feature Analysis of Intertwined Symmetric Protein Motifs for Topology Engineering. Giant 2024, 17, 100226.

  5. Fang, J.; Li, T.; Lee, J.; Im, D.; Xu, L.; Liu, Y.; Seo, J.; Zhang, W.-B.* A single-domain protein catenane of dihydrofolate reductase. Natl. Sci. Rev. 2023,10, nwad304.

  6. Qu, Z.; Fang, J.; Wang, Y.-X.; Sun, Y.; Liu, Y.; Wu, W.-H.; Zhang, W.-B.* A single-domain green fluorescent protein catenane. Nat. Commun. 2023,14, 3480.

  7. Liu, Y.; Bai, X.;Lyu, C.; Fang, J.; Zhang, F.; Wu, W.-H.; Wei, W.;*Zhang, W.-B.* Mechano-bioconjugation Strategy Empowering Fusion Protein Therapeutics with Aggregation Resistance, Prolonged Circulation, and Enhanced Antitumor Efficacy. J. Am. Chem. Soc. 2022,144, 18387-18396.

  8. Wu, W.-H.; Bai, X.; Shao, Y.;Yang, C.; Wei, J.; Wei, W.;*Zhang, W.-B.* Higher Order Protein Catenation Leads to an Artificial Antibody with Enhanced Affinity and In Vivo Stability. J. Am. Chem. Soc. 2021, 143, 18029-18040.

  9. Liu, Y.; Wu, W.-H.; Hong, S.; Fang, J.;Zhang, F.; Liu, G.-X.; Seol, J.;*Zhang, W.-B.* Lasso Proteins: Modular Design, Cellular Synthesis and Topological Transformation. Angew. Chem. Int. Ed. 2020, 59, 19153-19161.

  10. Liu, Y.;# Duan, Z.;# Fang, J.;# Zhang, F.; Xiao, J.;* Zhang, W.-B.* Cellular Synthesis and Crystal Structure of a Designed Protein Heterocatenane, Angew. Chem. Int. Ed. 2020, 59, 16122-16127.

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