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New Paper on Chem. Eur. J. was published as Hot Paper

Li Yuanhe

Our new paper regarding Diastereoselective Synthesis of Cyclopentanoids: Applications to the Construction of the ABCD Tetracyclic Core of Retigeranic Acid A has been published online in Chem. Eur. J. 2015, 21, 12596., which was chosen as Hot Paper. This achievement was completed by Jun-Lin Zhang with his coworkers Xiao Wang, Shuang Li, Dian Li and Song Liu, instructed by Prof. Zhen Yang, Dr. Jian-xian Gong and Prof. Dr. Yu Lan.

 

 

A concise and efficient approach for the construction of the tetracyclic carbon skeleton of retigeranic acid A is described. The key transformations include a novel Rh-catalyzed [3+2] cycloaddition of enyol to afford cyclopentanoid E, bearing two contiguous quaternary stereocenters at the bridgehead positions, and an intramolecular Pauson–Khand reaction to construct the advanced tetracyclic core structure of retigeranic acid A.