Home / Group News / Group News & Announcements
New Paper on Chem. Asian J. has been published online
Our new paper regarding Asymmetric Total Synthesis of (−)-Maoecrystal V has been published online in Chem. Asian J., 2015, Early View. This achievement was completed by Wei-bin Zhang and his coworkers Wen-bin Shao and Fu-zhuo Li instructed by Prof. Zhen Yang and Dr. Jian-xian Gong.
The asymmetric total synthesis of (-)-maoecrystal V, a novel cytotoxic pentacyclic ent-kaurane diterpene, has been accomplished. Key steps of the current strategy involve an early-stage semipinacol rearrangement reaction for the construction of the C10 quaternary stereocenter, a rhodium-catalyzed intramolecular O-H insertion reaction, and a sequential Wessely oxidative dearomatization/intramolecular Diels–Alder reaction to forge the pentacyclic framework of maoecrystal V.
