陈 兴

特聘研究员，博士生导师

电子信箱：xingchen#pku.edu.cn

课题组网站  http://www.chem.pku.edu.cn/xchengrp/

教育和研究背景

2002年 本科毕业于清华大学化学系。
2007年 获得加州大学伯克利分校化学博士学位，研究领域为化学生物学和纳米生物技术。
2007-2010年，在哈佛大学医学院从事博士后研究，研究领域为结构生物学和免疫生物学。
2010年9月- 至今，任北京大学化学学院化学生物学系 特聘研究员。

研究领域与兴趣

本课题组的研究兴趣集中于有机化学、纳米化学、糖生物学、细胞生物学的交叉领域。我们综合应用化学方法、生物手段和纳米技术，研究生命科学中的重要问题。
1.化学糖生物学(Chemical Glycobiology)
2.生物纳米技术

课题组网址：www.chem.pku.edu.cn/xchengrp 

发表论文

……………………………………………….2014

Xiao, M.; Lin, L.; Li, Z.; Liu, J.; Hong, S.; Li, Y.; Zheng, M.; Duan, X.; Chen, X. “SERS Imaging of Cell-Surface Biomolecules Metabolically Labeled With Bioorthogonal Raman Reporters” Chem. Asian J. 2014, DOI: 10.1002/asia.201402151.

Hong, S.; Chen, T.; Zhu, Y.; Li, A.; Huang, Y.; Chen, X. “Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules” Angew. Chem. Int. Ed. 2014, DOI: 10.1002/anie.201400328.

Lin, W.; Du, Y.; Zhu, Y.; Chen, X. “A Cis-membrane FRET-based Method for Protein-Specific Imaging of Cell-surface Glycans” J. Am. Chem. Soc. 2014,136, 679-687.

……………………………………………….2013

Li, S.; Zhang, L.; Yao, Q.; Li L.; Dong, N.; Rong, J.; Gao, W.; Ding, X.; Sun, L.; Chen, X.; Chen, S.; Shao, F. “Pathogen Blocks Host Death Receptor Signalling by Arginine GlcNAcylation of Death Domains” Nature 2013, 501, 242-246.

Xie, R.; Hong, S.; Chen, X. “Cell-selective Metabolic Labeling of Biomolecules with Bioorthogonal Functionalities” Curr. Opin. Chem. Biol. 2013, 17, 747-752.

Feng, L.; Hong, S.; Rong, J.; You, Q.; Dai, P.; Huang, R.; Tan, Y.; Hong, W.; Xie, C.; Zhao, J.; Chen, X. “Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans” J. Am. Chem. Soc. 2013, 135, 9244-9247

Lin, L.; Tian, X.; Hong, S.; Dai, P.; You, Q.; Wang, R.; Feng, L.; Xie, C.; Tian, Z.; Chen, X. “A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells.” Angew. Chem. Int. Ed. 2013, 52, 7266-7271.

Zhang, C.; Yin, A.; Jiang, R.; Rong, J.; Dong, L.; Zhao, T.; Sun, L.; Wang, J.; Chen, X.; Yan, C.; “Time-Temperature Indicator for Perishable Products Based on Kinetically Programmable Ag Overgrowth on Au Nanorods” ACS Nano 2013, 7, 4561-4568.

……………………………………………….2012

Rouhanifard, S. H.; Xie, R.; Zhang, G.; Sun, X.; Chen, X.; Wu, P. “Detection and Isolation of Dendritic Cells Using Lewis X-Functionalized Magnetic Nanoparticles” Biomacromolecules 2012, 13, 3039-3045.

Xie, R.; Hong, S.; Feng, L.; Rong, J.; Chen, X. “Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes” J. Am. Chem. Soc. 2012, 134, 9914-9917.

……………………………………………….2011

Wang, W.; Hong, S.; Tran, A.; Triano, R.; Jiang, H.; Liu, Y; Chen, X.; Wu, P. “Sulfated Ligands for the Copper(I)-catalyzed Azide Alkyne Cycloaddition” Chem. Asian J. 2011, 6, 2796-2802.

Hao, Z.; Hong, S.; Chen, X.; Chen, R. P. “Introducing Bioorthogonal Functionalities into Proteins in Living Cells” Acc. Chem. Res. 2011, 44, 742-751.


Prior to PKU:

Chen, X.; Yu, Y.; Mi, L.; Walz, T.; Springer, T. A. “Molecular Basis for Complement Recognition by Integrin αXβ2” Proc. Natl. Acad. Sci. USA 2012, 109, 4586-4591.

Shi, M.; Zhu, J.; Wang, R.; Chen, X.; Mi, L.; Walz, T.; Springer, T. A. “Latent TGF-β Structure and Activation ” Nature 2011, 474, 343-349.

Chen, X.; Xie, C.; Nishida, N.; Li, Z.; Walz, T.; Springer, T. A. “Requirement of Open Headpiece Conformation for Activation of Leukocyte Integrin αXβ2” Proc. Natl. Acad. Sci. USA 2010, 107, 14727-14732.

Xie, C; Zhu, J.; Chen, X.; Lizhi Mi; Nishida, N.; Springer, T. A. “Structure of Complement Receptor Tpye 4, An Integrin with An αI Domain” EMBO J. 2010, 29, 666-678.

Chang, P.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T; Bertozzi, C. R.; Wu, P.; “Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars” Angew. Chem. Int. Ed. 2009, 48, 4030-4033.

Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. “Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells” J. Am. Chem. Soc. 2009, 131, 890-891.

Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. “Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers” Angew. Chem. Int. Ed. 2008, 47, 5022-5055.

Chen, X.; Kis, A.; Zettl, A.; Bertozzi, C. R. “A Cell Nanoinjector Based on Carbon Nanotubes” Proc. Natl. Acad. Sci. USA 2007, 104, 8218-8222.

Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. “Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and their Display on Supported Bilayers” J. Am. Chem. Soc. 2007, 129, 5462-5471.

Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R. “Interfacing Carbon Nanotubes with Living Cells” J. Am. Chem. Soc. 2006, 128, 6292-6293.

Chen, X.; Lee G. S.; Zettl A.; Bertozzi, C. R. “Biomimetic Engineering of Carbon Nanotubes Using Cell Surface Mucin Mimics” Angew. Chem. Int. Ed. 2004, 43, 6111-6116.

Sun, X.; Chen, X.; Li, Y. “A CTAB-Assisted Hydrothermal Orientation Growth of ZnO Nanorods” Mater. Chem. Phys. 2003, 78, 99-104.

Sun, X.; Chen, X.; Li, Y. “Large-Scale Synthesis of Sodium and Potassium Titanate” Inorg. Chem. 2002, 41, 4996-4998.

Sun, X.; Chen, X.; Li, Y. “Evaporation Growth of Multipod ZnO Whisker Assisted by A Cu2+ Etching Technique” J. Crystal. Growth. 2002, 244, 218-223.

Chen, X.; Sun, X.; Li, Y. “Self-Assembling Vanadium Oxide Nanotubes by Organic Molecular Templates” Inorg. Chem. 2002, 41, 4524-4530.

Chen, X.; Deng, Z.; Li, Y.; Li, Y. “Hydrothermal Synthesis and Superparamagnetic Behaviors of A Series of Ferrite Nanoparticles” Chin. J. Inorg. Chem. 2002, 18, 460-464.