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贾桂芳

 

 

 

化学生物学 • 核酸化学,博士,副研究员
电子信箱:guifangjia#pku.edu.cn
 

教育与科研背景 


1998-2002 中国农业大学理学院,理学学士
2003-2008 中国农业大学理学院,理学博士
2007-2012 美国芝加哥大学化学系,访问学者、博士后
2012-至今 北京大学化学与分子工程学院,副研究员
 

研究领域与兴趣 


利用化学与生物学交叉学科的优势,采用化学生物学、结构生物学、细胞生物学、分子生物学、基因组学及有机合成等研究手段,对与核酸相关的最前沿与热点领域RNA表观遗传学方面展开研究,具体研究方向如下:

1.研究信使RNA的最主要修饰碱基N6-甲基腺嘌呤对信使RNA的基因表达、剪切、转译等调控功能;
2.研究RNA去甲基修饰蛋白酶的对RNA的调控功能和致病机理;
3.研究N6-甲基腺嘌呤在植物中的功能与机理;
4.利用化学二硫键交联技术对去甲基修饰蛋白酶与核酸复合物的结构解析和功能机理研究。
 

发表论文 


1.     Liu, J., Jia, G. *, Methylation modifications in eukaryotic messenger RNA, J Genet Genomics., 41, 21-33, 2014

2.     Liu, J.Z., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W., He, C. *, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol., 10, 93-5, 2013.

3.     Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., Ren, B., Pan, T., He, C.*, N6-methyladenosine-dependent regulation of messenger RNA stability. Nature,  505, 117-20, 2014.

4.     Fu, Y.#, Jia, G.#, Pang, X., Wang, R. N., Wang, X., Li, C. J., Smemo, S., Dai, Q., Bailey, K. A., Nobrega, M. A., Han, K.-L., Cui, Q., He, C.*, FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat. Commun., 4, 1798, doi: 10.1038/ncomms2822, 2013. (#co-first author)

5.     Jia, G., Fu, Y., He, C.*, Reversible RNA adenosine methylation in biological regulation. Trends Genet., 29, 108-15, 2013.

6.    Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, Charles J., Vågbø, Cathrine B., Shi, Y., Wang, W.-L., Song, S.-H., Lu, Z., Bosmans, Ralph P. G., Dai, Q., Hao, Y.-J., Yang, X., Zhao, W.-M., Tong, W.-M., Wang, X.-J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, Hans E., Klungland, A.*, Yang, Y.-G.*, He, C.*, ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Mol. Cell., 49, 18-29, 2013.

7.     Chen, B., Ye, F., Yu, L., Jia, G., Huang, X., Zhang, X., Peng, S., Chen, K., Wang, M., Gong, S., Zhang, R., Yin, J., Li, H., Yang, Y., Liu, H., Zhang, J., Zhang, H., Zhang, A., Jiang, H., Luo, C.*, Yang, C.G.*, “Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor”, J. Am. Chem. Soc., 134, 17963-71, 2012.

8.     Yi, C., Chen, B., Qi, B., Zhang, W., Jia, G., Zhang, L., Li, C. J., Dinner, A. R., Yang, C. G.*, He, C.* Duplex interrogation by a direct DNA repair protein in search of base damage. Nat. Struct. Mol. Biol., 19, 671-6, 2012.

9.     Jia, G.#, Fu, Y.#, Zhao, X.#, Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y. G., He, C.*, N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol., 7, 885-7, 2011. (#co-first author)

10.   Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.-G., Cui, Q., He, C.*, Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature, 468, 330-3, 2010.

11.   Jia, G.#, Yang, C-G.#, Yang, S., Jian, X., Yi, C., Zhou, Z., He, C.*, Oxidative demethylation of 3-meT and 3-meU in single-stranded DNA and RNA by mouse and human FTO, FEBS Lett., 2008, 582, 3313-3319. (#co-first author).

12.   Jia G, Lv C, Zhu W, Qiu J, Wang X, Zhou Z.*, Applicability of cloud point extraction coupled with microwave assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with flame photometry detection, J. Hazard Mater., 2008, 159, 300-305.

13.   Jia G, Li L, Qiu J, Wang X, Zhu W, Sun Y, Zhou Z.*, Determination of carbaryl and its metabolite 1-naphthol in water samples by fluorescence spectrophotometer after anionic surfactant micelle-mediated extraction with sodium dodecylsulfate, Spectrochim Acta Part A Mol. Biomol. Spectrosc., 2007, 67, 460-464. 

14.   Lv C, Jia G, Zhu W, Qiu J, Wang X, Zhou Z.*, Enantiomeric resolution of new triazole compounds by high perform liquid chromatography, J. Sep. Sci., 2007, 30, 344-351

15.   Wang X, Jia G, Qiu J, Diao J, Zhu W, Lv C, Zhou Z.*, Stereoselective degradation of fungicide Benalaxyl in soils and Cucumber plants, Chirality, 2007, 19, 300-306.

16.   Qiu J, Wang Q, Zhu W, Jia G, Wang X, Zhou Z.*, Stereoselective Determination of Benalaxyl in Plasma by ChiralHigh-Performance Liquid Chromatography with Diode Array Detector and Application to Pharmacokinetic Study in Rabbits, Chirality, 2007, 19(1), 51-55.

17.   Zhu W, Qiu J, Dang Z, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Degradation Kinetics of Tebuconazole in Rabbits, Chirality, 2007, 19(2), 141-147

18.   Zhu W, Dang Z, Qiu J, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Toxicokinetics and Tissue Distribution of Ethofumesate in Rabbits, Chirality, 2007, 19(8), 632-637.

19.   Jia G, Bi C, Wang Q, Qiu J, Zhou W, Zhou Z.*, Determination of Etofenprox in environmental samples by HPLC after anionic surfactant micelle-mediated extraction (coacervation extraction), Anal. Bioanal. Chem., 2006, 384 (6), 1423-1427.

20.   Wang Q, Qiu J, Zhu W, Jia G, Li J, Bi C, Zhou Z*, Stereoselective Degradation Kinetics of Theta-cypermethrin in Rats, Environ. Sci. Technol., 2006, 40(3), 721-726.

21.   Qiu J, Wang Q, Wang P, Jia G, Li J,  Zhou, Z*, Enantioselective degradation kinetics of Metalaxyl in Rabbits, Pestic. Biochem. Physiol., 2005, 83(1), 1-8.

22.   Wang Q, Qiu J, Wang P, Jia G, Wang P, Li J, Zhou Z.*, Stereoselective Kinetic Study of Hexaconazole Enantiomers in the Rabbit, Chirality, 2005, 17(4): 186-192.

23.   Jia G, Wang P Qiu J Sun Y Xiao Y, Zhou Z*, Determination of DNA with imidacloprid by a Resonance Light Scattering Technique at Nanogram Levels and Its ApplicationAnal. Lett., 2004, 37 (7), 1339-1354.

24.   Jie N*, Jia G, Hou S, Xiong Y, Dong Y. Determination of deoxyribonucleic acids by a resonance light scattering technique and its application, Spectrochim Acta Part A Mol. Biomol. Spetrosc., 2003, 59, 3295-3301.

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