时间：5月23日（周二）上午10 – 11:30
Mechanical signaling strongly influences embryological development, differentiation, morphogenesis, tissue patterning, and growth as well as various other biological functions. When mechanosensing, mechanotransduction and mechanoresponse are mis-regulated, diseases usually occur. In this talk, I will focus on two examples on how mechanical signals regulate living systems in disease and health, respectively. Firstly, I will discuss how soft matrices can induce human carcinoma cells to undergo a malignant progression. Secondly, I will show that, in living zebrafish, mechanical force can independently trigger calcium wave within vasculature. A quantitative understanding of how force links form and function of living systems will uncover the basic operating principles underlying biological processes, and inspire new technology development for diseases treatment and tissue regeneration.
Dr. Xin Tang will join the Department of Mechanical and Aerospace Engineering at University of Florida this fall. He is currently a Postdoctoral Fellow in the Department of Chemistry and Chemical Biology at Harvard University. He was a NSF-IGERT fellow and Mavis Future Faculty fellow, and received his Ph.D. from University of Illinois at Urbana-Champaign for studying the force-induced cancer metastasis and cardiomyocytes synchrony. His current research focus on in vivo functional imaging and unconventional mechano-electrophysiology.