[PUBLICATION] Wang Shuo reports the highest molecular weight of polysarsoine work in JACS

Feb. 2024

The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) of N-carboxyanhydride (NCA) is rare and challenging. In the latest work of Wang Shuo, he reports well-controlled ROP of sarcosine NCA (Sar-NCA) catalyzed by various carboxylic acids, which accelerate the polymerization rate up to 50 times, and enables the robust synthesis of pSar with unprecedented ultra-high molecular weight (UHMW) up to 586 kDa (DP ~ 8200) and exceptionally narrow dispersity (Ð) below 1.05.  This is the second first-authored research paper of Shuo, keep it on! [Link]