We have accomplished the first total synthesis of (-)-incarviatone A
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic […]
We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our
synthetic studies, we have developed a scalable and sequential C-H functionalization process for the rapid assembly of the highly functionalized indane skeleton. More interestingly, we have also identified a striking biomimetic cascade reaction to furnish the desired natural product in one step.