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Applying a chemoproteomic approach we uncovered a lot of novel bile acid interacting proteins

Recently, we have published a ACS Central Science paper, describing the?chemoproteomic profiling of bile acid interacting proteins.

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We have published a latest eLife paper to report the new CXMS method

To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemica…

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We have published a latest Cell Chemical Biology paper on necroptosis

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis Highlights Kongensin A (KA) is a potent inhibitor of necroptosis and an inducer of apoptosis KA in…

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We report the first scalable total synthesis of tetracyclic diterpenoid jungermannenones B and C

Reported is the first scalable synthesis of?rac-jungermannenones?B and C starting from the commercially available and inexpensive geraniol in 10 and 9 steps, respectively. The unique jungermannenone f…

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We report the first total synthesis and stereochemical configuration reassignment of aspergillomarasmine A

Abstract: The increase and spread of Gram-negative bacteria resistant to almost all currently available β-lactam antibiotics is a major global health problem. The cause for drug resistance is primari…

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We have accomplished the first total synthesis of (-)-incarviatone A

We have accomplished the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from inexpensive phenylacetic acid. In the course of our synthetic studies, we have developed a scalable a…

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Uncovered the mode of action for ainsliadimer A

Ting and Chao’s latest research breakthough on the chemical biology studies of complex natural product has been published on Nature Communications. Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Che…

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Prof. Lei received 2015 The Distinguished Lectureship Award by CSJ

Prof. Lei recently received “2015 The Distinguished Lectureship Award” by Chemical Society of Japan (CSJ). He was invited to attend the CSJ annual meeting in Chiba, March 26-29 and present a keynote l…

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 We have discovered a new mode of anticancer action of the natural product ainsliatrimer A

Natural products have played a crucial role in the development of new therapeutic agents. However, the target identification for natural products is still challenging due to the structural complexity…

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Dr. Xiaoguang Lei received the Young Chemical Biologist award of the International Chemical Biology Society

Dr. Xiaoguang Lei received the Young Chemical Biologist award of the International Chemical Biology Society based on his contributions to chemical biology.

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 Probing the Anti-cancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation

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A Roche sponsored postdoc fellowship is immediately available!

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A Bioorthogonal Ligation Enabled by Click Cycloaddition of o-Quinolinone Quinone Methide and Vinyl Thioether

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