2014 - 特聘研究员，北京大学化学与分子工程学院 研究员，北京大学软物质科学与工程中心 研究兴趣与领域：高分子化学与材料，生物医药工程，化学生物学 2011 – 2014 博士后, 斯克里普斯研究所 (The Scripps Research Institute) 化学系 研究经历：位点特异的抗体偶联物的合成和癌症治疗的应用 导师: Prof. Peter G. Schultz 2006 – 2011 博士, 美国伊利诺伊大学香槟分校 (UIUC) 材料科学与工程系 研究经历：NCA可控开环聚合，聚多肽高分子的合成和生物应用 导师: Prof. Jianjun Cheng 2002 - 2006 学士，北京大学化学与分子工程学院 研究经历：磁性金属-有机框架化合物；导师：高松教授，院士 有机与高分子发光二极管材料；导师：裴坚教授
2013 ACS-AKzoNobel Award for Outstanding Graduate Research in Polymer Chemistry (only one awardee each year) 2012 Honorable Mention Award, IUPAC Prize for Young Chemists 2011-2014 Damon Runyon Cancer Research Foundation Postdoctoral Fellowship Award 2011 Racheff-Intel Awards, UIUC 2010 国家优秀自费留学生奖学金 2010 Yee Memorial Fellowship, UIUC 2010 6th Excellence in Graduate Polymer Research Symposium, ACS 2002-2006 北京大学明德奖学金（四年） 2002 第34界国际化学奥林匹克竞赛金牌
Biological macromolecules, such as DNA and protein, are the products of billions of years of natural evolution. They are distinguished from synthetic polymers by their defined primary sequences and near-perfect homogeneity (if we do not consider epigenetic modifications), which form the physical basis for a wide scope of life-defining biochemical mechanisms, ranging from the storage of genetic information to protein folding and macromolecular recognition and interaction. By all means, this delicacy and power of nature are still beyond the current capability of chemists. At the Lu Lab, we are dedicated to bridging the worlds of biomacromolecules and synthetic polymers using an integrated, interdisciplinary approach encompassing cutting-edge technologies in organic chemistry, polymers science, cell biology, immunology and biomedicine. We hope to apply our arsenal of scientific knowledge and tools to the understanding of fundamental principles that govern the functions of biological macromolecules and to the development of novel materials that can fulfill a diversity of engineering and medical needs.
Specifically, our research interests span the following domains:
Developing new technologies and methodologies to conveniently synthesize site-specific and structurally well-defined hybrid materials composed of biological macromolecules and synthetic polymers;
Creating next-generation synthetic mimics of biological micromolecules that can achieve precise modulation of complex pathways;
Developing materials and platforms for various biomedical applications, including RNA therapy and immunotherapy for cancer treatment, vaccines for infectious diseases, etc;
Seeking scalable, biomemetic approaches to generate high-molecular-weight polymers with absolute monodispersity and defined sequences.
We are actively recruiting members at all levels including graduate students, postdocs, technicians, and undergraduate students. We especially welcome self-motivated and collaborative colleagues with strong determination, commitment, and potential of excellence. Interested candidates are encouraged to send informal inquiries and/or formal application containing their cover letter and CV to email@example.com.
As a commitment, we consider it our highest priority to create a friendly and dynamic research environment, inspire young scientists continuously to expand their scientific passion and horizon, help them develop successful career paths, and shape them for their next ideal positions in either academia or industry.
Hua Lu*, Jing Wang, Ziyuan Song, Lichen Yin, Yanfeng Zhang, Haoyu Tang, Chunlai Tu, Yao Lin*and Jianjun Cheng*, " Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, Self-assembly and Biological Applications", Chem. Comm. 2014, 50, 139-155(Invited Feature Article)
Hua Lu†, Danling Wang†, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, Barney Barnett and Peter G. Schultz*, "Site-specific Antibody-polymer Conjugates for siRNA Delivery ", J. Am. Chem. Soc., 2013, 135, 13885–13891 (†equal contribution)
Nathan Gabrielson, Hua Lu, Lichen Yin, Kyung Hoon Kim and Jianjun Cheng*, "A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells ", Mol. Ther. 2012, 20, 1599-1609
Nathan Gabrielson†, Hua Lu†, Lichen Yin, Dong Li, Fei Wang, and Jianjun Cheng*,"A Reactive Cationic α-Helical Polypeptide Template for Non-Viral Gene Delivery", Angew. Chem. Int. Ed. 2012, 51, 1143-1147 (†equal contribution) Highlighted by Chemical and Engineering News, issue of Dec. 19, 2011
Hua Lu, Jing Wang, Yugang Bai, Jason Long, Shiyong Liu*, Yao Lin* and Jianjun Cheng*, "Ionic Polypeptides with Unusual Helical Stability", Nat. Commun., 2011, 2, 206
Jing Wang, Hua Lu, Ranjan Kamat , Sai Venkatesh Pingali , Volker S. Urban, Jianjun Cheng* and Yao Lin*, “Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers”, J. Am. Chem. Soc. 2011, 133, 12906-12909. Highlighted by Chemical and Engineering News, issue of Aug. 15, 2011
Hua Lu, Yugang Bai, Jing Wang, Yao Lin and Jianjun Cheng*, "Controlled Ring-Opening Polymerization of γ-(4-Vinylbenzyl)-L-Glutamate N-Carboxyanhydride for the Synthesis of Functional Polypeptides", Macromolecules, 2011, 44, 6237-6240; Cover art of Macromolecules, Volume 44, Issue16, August 23, 2011
Hua Lu, Jing Wang, Yao Lin* and Jianjun Cheng*, “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, J. Am. Chem. Soc. 2009, 131, 13582-13583 Highlighted by Chemical and Engineering News, issue of Sept. 14, 2009.
Hua Lu and Jianjun Cheng*, “N-Trimethylsilyl amines for controlled ring-opening polymerization of amino acid N-carboxyanhydrides and facile end group functionalization of polypeptides”, J. Am. Chem. Soc. 2008, 130, 12562-12563
Hua Lu and Jianjun Cheng*, “Hexamethyldisilazane-Mediated Controlled Polymerization of alpha-Amino Acid N-Carboxyanhydrideshydrides”, J. Am. Chem. Soc. 2007, 129, 14115-14116