报告题目：Novel Optical Properties of Plasmonic Metal Nanostructures: A Case Study of Hollow Gold Nanospheres (HGNs) and Their Applications in Sensing,
Imaging, and Cancer Therapy
报告人： Prof. Jin Zhong Zhang
              Department of Chemistry and Biochemistry
              University of California Santa Cruz
地    点： 北京大学化学院A201报告厅
时    间： 2018年09月14日(星期五) 上午 09:30
主请人： 张  锦  教授

摘  要:
As an important member of the family of plasmonic metal nanostructures, hollow gold nanospheres (HGNs) exhibit unique optical and photothermal properties useful for many applications including SERS (surface enhanced Raman scattering) sensing, optical imaging, drug delivery, and photothermal therapy (PTT) of cancer.  We have conducted extensive studies of the mechanism behind the growth of HGNs and determined the important role several factors including oxygen in the reaction process using a number of spectroscopic techniques including X-ray spectroscopy.  Based on the better understanding of the growth mechanism, we are able to control the synthesis of HGNs with well-defined size and shell thick, allowing surface plasmon resonance (SPR) at specific wavelength to be achieved, especially the highly desired near IR (NIR) region.  In addition, we can control the surface morphology of the HGNs by varying surface ligand molecules.  The synthesized HGNs have been used for in vitro studies of HGN-mediated PTT of oral squamous cell carcinoma (A431), with the primary goal to optimize the bioconjugation and the HGNs for best PTT performance.  I will also give some background information about our previous work that led to the development of the HGNs.  If time permits, I will also make a quick comparison between plasmonic nanostructures and semiconductor quantum dots (QDs) in terms of their optical properties and applications.