Peng Chen

Professor and Chairman, Dept. of Chemical Biology


Email: pengchen at

Phone: 86-10-62755773



• Protein bioorthogonal chemistry

• Host-pathogen interactions

• Protein therapeutic engineering




Ph.D in Chemistry (2007) University of Chicago Chicago, USA


B.S. in Chemistry, Peking University Beijing, China


B.S. Double degree in Economics, Peking University Beijing, China



2016/01-present, Senior Investigator, Peking-Tsinghua Center for Life Science

2015/01-present, Chairman, Department of Chemical Biology, Peking University

2014/08-present, Professor, Department of Chemical Biology, Peking University

2011/05-2015/12, Investigator, Peking-Tsinghua Center for Life Sciences

2009/07-2014/07, Investigator, Department of Chemical Biology, College of Chemistry, Peking University

2007-2009, Postdoctoral Fellow, The Scripps Research Institute, Advisor: Prof. Peter G. Schultz

2002-2007, Research Assistant, The University of Chicago, Chicago. Advisor: Prof. Chuan He



2016    Tan Kah Kee Young Scientist Award

2016    Young Scientist Award, Ministry of Education (China)

2016    OKeanos-CAPA Young Investigator Award at the Chemistry and Biology Interface

2015    China Association for Instrumental Analysis (CAIA) Award

2015    The Chemical Society of Japan Distinguished Lectureship Award

2015    Young Science and Technology Innovation Talents (China)

2014    Roche Chinese Young Investigator Award

2014    (RSC) Chem Soc Rev Emerging Investigator Lectureship

2014    CAPA Biomatik Distinguished Faculty Award

2013    National Young Scientist Award (China)

2013    National Program for Special Support of Eminent Professionals (China)

2012    National Program for Special Support of Eminent Professionals (China)

2012    CCS (Chinese Chemical Society) Young Investigator Award

2011    WuXi PharmaTech Life Science and Chemistry Award



(1) Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J, Chen P*. Palladium-triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-caged Tyrosine. J. Am. Chem. Soc. 2016, 138, 15118-15121

(2) Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S, Chen P*. Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance. Proc. Natl. Acad. Sci. USA. 2016, 113, 10872-10877.

(3) Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen P*. Bioorthogonal chemical activation of kinases in living systems, ACS Cent. Sci. 2016, 2, 325-331.

(4) Li J, Chen P*. Development and application of bond cleavage reactions in bioorthogonal chemistry, Nat. Chem. Biol. 2016, 12, 129-137.

(5) Li J, Jia S, Chen P*. Diels-Alder reaction-triggered bioorthogonal protein activation in living cells, Nat. Chem. Biol. 2014, 10, 1003-1005.

(6) Lin S, He D, Long T, Zhang S, Meng R, Chen P*. Genetically encoded cleavable protein photocrosslinker, J. Am. Chem. Soc. 2014, 136, 11860-11863.

(7) Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P*. Palladium-triggered deprotection chemistry for protein activation in living cells, Nat. Chem. 2014, 6, 352-361.

(8) Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao B, Zeng S, Chen X, Chan J, He C*, Chen P*. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli, Nat. Chem. Biol. 2014, 10, 21-28.

(9) Li J, Lin S, Wang J, Jia S, Yang M, Zhang X, Hao Z, Chen P*. Ligand-free palladium-mediated site-specific protein labeling inside Gram-negative bacterial pathogens, J. Am. Chem. Soc. 2013, 135, 7330-7338.

(10) Zhang M, Lin S, Song X, Liu J, Fu Y, Fu X, Chang Z*, and Chen, P*. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance, Nat. Chem. Biol, 2011, 7, 671-7.


(1) Jiang H, Chen Y, Chen P and Zhang L, “Chemical Biology Frontier and Perspective”. China Science Publishing (2013), ISBN: 978-7-03-037949-8

(2) Liu L, Chen P, Zhao J and He C “Principles of Chemical Biology”, China Science Publishing Group, (2010), ISBN: 978-7-03-028767-0.

(3) “The development Strategy of Chemical Biology in China”, China Science Publishing Group, (2015), Chapter 2 and 6.

(4) “China Medical Technology Report”, China Science Publishing Group, (2015), Chapter 3.

(5) Liu L, Chen P, Li Y, etc. “Chemical Biology Experiments”, USTC Press, (2015), ISBN: 978-7-312-03728-3.



Fall 2013-present, “Chemical Biology Track”, Graduate Course, CLS, PKU.

Fall 2009-present, “Introduction to Chemical Biology”, Graduate Course, PKU.

Spring 2012-present, “Bioinorganic Chemistry”, Graduate Course, PKU

Fall 2010-2014, “Today’s Chemistry”, Freshman Course, PKU.